公开(公告)号：US11084781B2

公开(公告)日：2021-08-10

申请号：US16612680

申请日：2018-05-10

Applicant: Research Triangle Institute

Inventor： Yanan Zhang ,  Thuy Nguyen ,  Nadezhda German

IPC: C07C275/38 ,  C07D205/04 ,  C07D207/335 ,  C07D211/38 ,  C07D213/643 ,  C07D215/12 ,  C07D239/26 ,  C07D295/135 ,  C07D333/20 ,  C07D487/08 ,  C07D491/107 ,  A61P25/30

Abstract: The present invention provides novel diarylurea derivatives (compounds of formula (I)) and their uses. The compounds of the present invention are demonstrated to be allosteric modulators of the CB1 receptor, and therefore useful for the treatment of diseases and conditions mediated by CB1.