公开(公告)号：US11491136B2

公开(公告)日：2022-11-08

申请号：US16485570

申请日：2018-02-13

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： Yanan Zhang ,  Thuy Nguyen

IPC: A61K31/401 ,  A61P25/04 ,  A61P25/36 ,  A61K31/40 ,  A61P25/00

Abstract: Neuropeptide FF receptor modulators based on a proline scaffold are provided which offer NPFF receptor potencies in the nanomolar range and antagonistic selectivity for the NPFF1 receptor. Methods, compounds and compositions for modulating the function of neuropeptide FF receptors are provided for pharmacotherapies capable of influencing conditions or disorders affected by the neuropeptide FF receptors.

公开(公告)号：US20240058303A1

公开(公告)日：2024-02-22

申请号：US18484116

申请日：2023-10-10

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： Yanan Zhang ,  Thuy Nguyen

IPC: A61K31/40 ,  A61P25/00

CPC classification number: A61K31/40 ,  A61P25/00

Abstract: Neuropeptide FF receptor modulators based on a proline scaffold are provided which offer NPFF receptor potencies in the nanomolar range and antagonistic selectivity for the NPFF1 receptor. Methods, compounds and compositions for modulating the function of neuropeptide FF receptors are provided for pharmacotherapies capable of influencing conditions or disorders affected by the neuropeptide FF receptors.

公开(公告)号：US11826350B2

公开(公告)日：2023-11-28

申请号：US17937450

申请日：2022-10-02

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： Yanan Zhang ,  Thuy Nguyen

IPC: A61K31/401 ,  A61P25/04 ,  A61P25/36 ,  A61K31/40 ,  A61P25/00

CPC classification number: A61K31/40 ,  A61P25/00

Abstract: Neuropeptide FF receptor modulators based on a proline scaffold are provided which offer NPFF receptor potencies in the nanomolar range and antagonistic selectivity for the NPFF1 receptor. Methods, compounds and compositions for modulating the function of neuropeptide FF receptors are provided for pharmacotherapies capable of influencing conditions or disorders affected by the neuropeptide FF receptors.

公开(公告)号：US20230091922A1

公开(公告)日：2023-03-23

申请号：US17937450

申请日：2022-10-02

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： Yanan Zhang ,  Thuy Nguyen

IPC: A61K31/40 ,  A61P25/00

Abstract: Neuropeptide FF receptor modulators based on a proline scaffold are provided which offer NPFF receptor potencies in the nanomolar range and antagonistic selectivity for the NPFF1 receptor. Methods, compounds and compositions for modulating the function of neuropeptide FF receptors are provided for pharmacotherapies capable of influencing conditions or disorders affected by the neuropeptide FF receptors.

公开(公告)号：US11084781B2

公开(公告)日：2021-08-10

申请号：US16612680

申请日：2018-05-10

Applicant: Research Triangle Institute

Inventor： Yanan Zhang ,  Thuy Nguyen ,  Nadezhda German

IPC: C07C275/38 ,  C07D205/04 ,  C07D207/335 ,  C07D211/38 ,  C07D213/643 ,  C07D215/12 ,  C07D239/26 ,  C07D295/135 ,  C07D333/20 ,  C07D487/08 ,  C07D491/107 ,  A61P25/30

Abstract: The present invention provides novel diarylurea derivatives (compounds of formula (I)) and their uses. The compounds of the present invention are demonstrated to be allosteric modulators of the CB1 receptor, and therefore useful for the treatment of diseases and conditions mediated by CB1.

公开(公告)号：US20200030287A1

公开(公告)日：2020-01-30

申请号：US16485570

申请日：2018-02-13

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： Yanan Zhang ,  Thuy Nguyen

IPC: A61K31/40 ,  A61P25/00

Abstract: Neuropeptide FF receptor modulators based on a proline scaffold are provided which offer NPFF receptor potencies in the nanomolar range and antagonistic selectivity for the NPFF1 receptor. Methods, compounds and compositions for modulating the function of neuropeptide FF receptors are provided for pharmacotherapies capable of influencing conditions or disorders affected by the neuropeptide FF receptors.