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公开(公告)号：US20210402394A1
公开(公告)日：2021-12-30
申请号：US17304344
申请日：2021-06-18
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Adrian Sievers-Engler
Abstract: A sample concentrating unit and a sample concentrating method are described, which enable fast, precise and reproducible analyte concentration in a sample by evaporation of sample solvent. A specifically directed gas stream in cooperation with a vacuum generated in the sample concentrating unit keeps the sample at boiling point during the entire evaporation procedure while reducing analyte loss and risk of cross-contamination. The fully automated sample concentrating unit is designed to be integrated into an in-vitro diagnostic analyzer.
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公开(公告)号：US12194463B2
公开(公告)日：2025-01-14
申请号：US17304344
申请日：2021-06-18
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Adrian Sievers-Engler
Abstract: A sample concentrating unit and a sample concentrating method are described, which enable fast, precise and reproducible analyte concentration in a sample by evaporation of sample solvent. A specifically directed gas stream in cooperation with a vacuum generated in the sample concentrating unit keeps the sample at boiling point during the entire evaporation procedure while reducing analyte loss and risk of cross-contamination. The fully automated sample concentrating unit is designed to be integrated into an in-vitro diagnostic analyzer.
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公开(公告)号：US11408865B2
公开(公告)日：2022-08-09
申请号：US16543000
申请日：2019-08-16
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Adrian Sievers-Engler
Abstract: A sample injector is disclosed comprising a switching valve comprising an input port, an aspiration/dispensing port, a loop input port and a loop output port, a pump port and a column port, an aspiration pump connected to the aspiration/dispensing port via a buffer loop for aspirating a sample into the buffer loop when the aspiration/dispensing port is connected to the loop input port, a sample loop connected to the switching valve between the loop input port and the loop output port, for receiving the sample aspirated into the buffer loop when the loop input port is connected to the aspiration/dispensing port, a column connected to the column port, and a pump connected to the pump port, for injecting the sample received into the sample loop into the column when the pump port is connected to the loop output port and the column port is connected to the loop input port.
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Patent Agency Ranking
公开(公告)号：US20240248069A1
公开(公告)日：2024-07-25
申请号：US18566548
申请日：2022-05-31
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Adrian Sievers-Engler , Tibor Toth
CPC classification number: G01N30/7266 , G01N2030/621
Abstract: An analyzer system (110) is disclosed. The analyzer system (110) comprises:
at least one mass spectrometry device (112) having at least one electrospray ion source nozzle (114);
at least one liquid supply (116), wherein the liquid supply (116) is configured for providing at least one liquid having at least one analyte;
at least one gas supply (118), wherein the gas supply (118) is configured for providing at least one gas; and
at least one dopand gas supply (120), wherein the dopand gas supply (120) is configured for providing at least one chemical dopand gas having at least one chemical dopand (122) to the analyte provided by the liquid supply (116);
wherein the liquid supply (116) and the gas supply (118) are coupled to the mass spectrometry device (112) via the electrospray ion source nozzle (114), wherein the dopand gas supply (120) is connected to the gas supply (118).-
公开(公告)号：US20210003541A1
公开(公告)日：2021-01-07
申请号：US16892787
申请日：2020-06-04
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Adrian Sievers-Engler
Abstract: A liquid chromatographic (LC) system is introduced which comprises at least one fluidic stream, the fluidic stream comprising a sample-injection valve, a trap-bypass-selection valve, a column-bypass valve, a load-elute valve and a trap-selection valve. Also, a liquid chromatographic (LC) system is introduced which comprises at least one fluidic stream. The fluidic stream comprises a first substream and a second substream. The first substream comprises a first sample-injection valve, a load-elute valve and a trap-selection valve. The second substream comprises a second sample-injection valve and a column-bypass valve. The fluidic stream further comprises a trap-LC substream transfer valve and a substream-selection valve. The LC systems provide a broad choice of chromatographic options and modes and enable to flexibly and rapidly switch between them.
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公开(公告)号：US11454615B2
公开(公告)日：2022-09-27
申请号：US15931152
申请日：2020-05-13
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Adrian Sievers-Engler
Abstract: A liquid chromatographic (LC) system and a method of exchanging a liquid in an LC system are disclosed. The LC system includes an LC pump with at least one pump head having a primary and a secondary pump head, each with a syringe-like cylinder body having an inner wall surface and a plunger translatable through the cylinder body leaving an interspace between the inner wall surface and the plunger when the plunger is translated through the cylinder body, an upstream inlet valve configured to allow liquid into the cylinder body and a downstream outlet valve configured to allow liquid out of the cylinder body. The LC system further includes at least one liquid-exchange pump connected either to the upstream inlet valve of the primary pump head or to the downstream outlet valve of the secondary pump head.
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公开(公告)号：US11300548B2
公开(公告)日：2022-04-12
申请号：US16892787
申请日：2020-06-04
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Adrian Sievers-Engler
Abstract: A liquid chromatographic (LC) system is introduced which comprises at least one fluidic stream, the fluidic stream comprising a sample-injection valve, a trap-bypass-selection valve, a column-bypass valve, a load-elute valve and a trap-selection valve. Also, a liquid chromatographic (LC) system is introduced which comprises at least one fluidic stream. The fluidic stream comprises a first substream and a second substream. The first substream comprises a first sample-injection valve, a load-elute valve and a trap-selection valve. The second substream comprises a second sample-injection valve and a column-bypass valve. The fluidic stream further comprises a trap-LC substream transfer valve and a substream-selection valve. The LC systems provide a broad choice of chromatographic options and modes and enable to flexibly and rapidly switch between them.
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公开(公告)号：US20200064314A1
公开(公告)日：2020-02-27
申请号：US16543000
申请日：2019-08-16
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Adrian Sievers-Engler
Abstract: A sample injector is disclosed comprising a switching valve comprising an input port, an aspiration/dispensing port, a loop input port and a loop output port, a pump port and a column port, an aspiration pump connected to the aspiration/dispensing port via a buffer loop for aspirating a sample into the buffer loop when the aspiration/dispensing port is connected to the loop input port, a sample loop connected to the switching valve between the loop input port and the loop output port, for receiving the sample aspirated into the buffer loop when the loop input port is connected to the aspiration/dispensing port, a column connected to the column port, and a pump connected to the pump port, for injecting the sample received into the sample loop into the column when the pump port is connected to the loop output port and the column port is connected to the loop input port.
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