专利检索 ap:("SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES") AND inv:"Wei ZHU" 第 1 页

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发明申请
FLUORINATED CYCLOPROPYLAMINE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND USES THEREOF 审中-公开

公开(公告)号：US20190100507A1

公开(公告)日：2019-04-04

申请号：US16085311

申请日：2017-03-16

申请人： SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： Hong LIU , Jia LI , Jiang WANG , Mingbo SU , Shuni WANG , Yubo ZHOU , Wei ZHU , Wei XU , Chunpu LI , Hualiang JIANG , Kaixian CHEN

IPC分类号： C07D401/12 , C07D401/06 , C07D405/12 , C07D409/12 , C07D409/14 , C07D409/06 , C07D417/12 , C07D471/04 , C07D205/04 , C07D265/30 , C07D211/38 , C07D211/96 , A61P35/00

摘要： Provided is a fluorinated cyclopropylamine compound represented by formula I, a racemate thereof, an R-isomer thereof, an S-isomer thereof, a pharmaceutical salt thereof, and a mixture thereof. Also provided are pharmaceutical compositions containing the compound, a preparation method for the compound, and uses thereof as a lysine specific demethylase 1 (LSD1) inhibitor, and in the treatment of cancers.