-
![NOVEL PHARMACEUTICAL USE OF THIOPHENE [3,2-D] PYRIMIDINE-4-KETONE COMPOUND](/abs-image/US/2021/01/21/US20210015824A1/abs.jpg.150x150.jpg)
公开(公告)号：US20210015824A1
公开(公告)日：2021-01-21
申请号：US16978563
申请日：2019-03-08
发明人： Hong LIU , Jia LI , Jiang WANG , Yi ZANG , Jian LI , Jingya LI , Dandan SUN , Hualiang JIANG , Kaixian CHEN
IPC分类号： A61K31/5377 , A61K31/519 , A61P1/16
摘要： Disclosed is use of a thieno[3,2-d]pyrimidin-4-one compound represented by general formula (I). Definition of each substituent is as stated in the description and claims, and the compound is used for preparing medicines for treating and/or preventing liver fibrosis and related diseases or preparing a DPP-4 inhibitor, or is used as a DPP-4 inhibitor.
-
2.发明申请公开(公告)号：US20190100507A1
公开(公告)日：2019-04-04
申请号：US16085311
申请日：2017-03-16
发明人： Hong LIU , Jia LI , Jiang WANG , Mingbo SU , Shuni WANG , Yubo ZHOU , Wei ZHU , Wei XU , Chunpu LI , Hualiang JIANG , Kaixian CHEN
IPC分类号： C07D401/12 , C07D401/06 , C07D405/12 , C07D409/12 , C07D409/14 , C07D409/06 , C07D417/12 , C07D471/04 , C07D205/04 , C07D265/30 , C07D211/38 , C07D211/96 , A61P35/00
摘要： Provided is a fluorinated cyclopropylamine compound represented by formula I, a racemate thereof, an R-isomer thereof, an S-isomer thereof, a pharmaceutical salt thereof, and a mixture thereof. Also provided are pharmaceutical compositions containing the compound, a preparation method for the compound, and uses thereof as a lysine specific demethylase 1 (LSD1) inhibitor, and in the treatment of cancers.
-
3.发明公开公开(公告)号：US20240262860A1
公开(公告)日：2024-08-08
申请号：US18014932
申请日：2021-07-05
发明人： Hong LIU , Jiang WANG , Yichu LIU , Changyue YU , Yibing WANG , Hualiang JIANG , Kaixian CHEN
IPC分类号： C07J63/00 , A61K31/704 , A61P3/10 , A61P31/14 , A61P31/16
CPC分类号： C07J63/008 , A61K31/704 , A61P3/10 , A61P31/14 , A61P31/16
摘要： The present invention provides a pentacyclic triterpenoid glycoside compound, and a preparation method therefor and a use thereof. Specifically, the present invention provides a compound as shown in formula I. The definition of each group is described in the description. The compound can be used for preparing a medicament for treating metabolic diseases such as diabetes and viral diseases caused by influenza virus, coronavirus and the like.
-
公开(公告)号：US20190031678A1
公开(公告)日：2019-01-31
申请号：US16087318
申请日：2017-03-22
发明人： Hong LIU , Jiang WANG , Jian LI , Jia LI , Jingya LI , Hualiang JIANG , Xiaomin LUO , Kaixian CHEN
IPC分类号： C07D495/04 , A61P3/10
摘要： The invention relates to a salt form of (R)-methyl-2-(3-aminopiperidin-1-yl)-3-(2-cyanobenzyl)-4-carbonyl-3,4-dihydrothiophene[3,2-d]pyrimidine-6-carboxylic acid and a preparation method for the salt form. Also disclosed is a pharmaceutical composition of the formula I compound salt form. The salt form of the invention provides powerful in vivo hypoglycemic activity and is expected to be a novel pharmaceutical active ingredient for treating or preventing diabetes mellitus type 2 and/or complications of diabetes mellitus type 2
-
5.发明公开公开(公告)号：US20240208954A1
公开(公告)日：2024-06-27
申请号：US18013696
申请日：2021-06-29
发明人： Hong LIU , Jiang WANG , Cen XIE , Yameng LIU , Shulei HU , Cuina LI , Feng GAO , Kanglong WANG , Yong WANG , Xianchun ZHONG , Yuqiang SHI , Hualiang JIANG , Kaixian CHEN
IPC分类号： C07D413/10 , A61K31/4245 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/498 , A61K31/675 , A61P1/16 , A61P3/04 , A61P3/06 , A61P3/10 , C07D271/06 , C07D413/14 , C07F9/6558
CPC分类号： C07D413/10 , A61K31/4245 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/498 , A61K31/675 , A61P1/16 , A61P3/04 , A61P3/06 , A61P3/10 , C07D271/06 , C07D413/14 , C07F9/65583
摘要： The present invention relates to the fields of pharmaceutical chemistry and pharmacotherapeutics, and in particular to a compound as represented by general formula I, a racemate, an R-isomer, an S-isomer and a pharmaceutically acceptable salt thereof and a mixture of same, a preparation method therefor, a pharmaceutical composition containing the compound and the use thereof as an SIP receptor agonist. The oxadiazole compound involved in the present invention can be used for treating SIP receptor agonist related diseases.
-
公开(公告)号：US20190233456A1
公开(公告)日：2019-08-01
申请号：US16337338
申请日：2017-09-19
发明人： Hong LIU , Jiang WANG , Shengbin ZHOU , Panfeng PENG , Yong NIAN , Shuni WANG , Shuangjie SHU , Hao SHEN , Hualiang JIANG , Kaixian CHEN
IPC分类号： C07F15/04 , C07D207/16
CPC分类号： C07F15/045 , C07C227/34 , C07C229/34 , C07D207/16 , C07D401/04 , C07D409/12 , C07F15/04 , Y02P20/55
摘要： Disclosed is a method for synthesizing a novel chiral ligand, a metal chelate, a variety of non-natural amino acids, Maraviroc and a key intermediate thereof. In the invention, (R)-2-methyl proline is selected and used as a starting raw material, (S)-β3-amino acid is obtained by asymmetric resolution induced by using a nickel chelate, and Maraviroc is synthesized by using (S)-3-amino-3-phenylpropionic acid as a key intermediate with a high yield and the ee value reaching 98.2% or more. The method of the present invention has widely available materials, mild synthetic process conditions, is easy to control, and produces a product of a high optical purity.
-
公开(公告)号：US20190100529A1
公开(公告)日：2019-04-04
申请号：US16087317
申请日：2017-03-20
发明人： Hong LIU , Jiang WANG , Jian LI , Jia LI , Jingya LI , Hualiang JIANG , Xiaomin LUO , Kaixian CHEN
IPC分类号： C07D495/04 , A61P3/10
摘要： The invention describes a polymorph of (R)-methyl-2-(3-aminopiperidin-1-yl)-3-(2-cyanobenzyl)-4-carbonyl-3,4-dihydrothiophene[3,2-d]pyrimidine-6-carboxylic acid maleate and a preparation method therefor. The polymorph is a crystal having high stability and low hygroscopicity, and the crystal form is selected from crystal form A, crystal form B and crystal form C. Furthermore, the crystal form has a strong in-vivo hypoglycemic activity and can be used for the preparation of a novel drug for the treatment or prevention of diabetes mellitus type H and/or complications of diabetes mellitus type H.
-
公开(公告)号：US20240279177A1
公开(公告)日：2024-08-22
申请号：US18392472
申请日：2023-12-21
申请人： JIANGSU LIANHUAN PHARMACEUTICAL CO., LTD. , SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
发明人： Hong LIU , Ben NIU , Chunpu LI , Jianping CHEN , Kun HUANG , Jiang WANG
IPC分类号： C07D211/60 , C07D401/12 , C07D409/12
CPC分类号： C07D211/60 , C07D401/12 , C07D409/12
摘要： The present invention relates to the fields of medicinal chemistry and pharmaco therapeutics, and specifically to a method for preparing a compound of formula I and a chemically acceptable salt thereof.
-
公开(公告)号：US20180305390A1
公开(公告)日：2018-10-25
申请号：US15738675
申请日：2016-06-23
发明人： Hong LIU , Jia LI , Jiang WANG , Jingya LI , Hui CHEN , Dan LI , Jian LI , Yibing WANG , Hualiang JIANG , Kaixian CHEN
CPC分类号： C07H19/01 , A61K31/35 , A61K31/381 , A61K31/427 , A61K31/4436 , A61P3/08 , C07D493/10
摘要： C, O-spiro aryl glycoside compounds are provided. Specifically provided are C, O-spiro aryl glycoside compounds represented by the formula (I), wherein the definitions of each variable group are described in the specification. Also provided are methods of preparing and using the C, O-spiro aryl glycoside compounds. The C, O-spiro aryl glycoside compounds can be used as SGLT2 inhibitors and for treating diseases, such as diabetes, atherosclerosis, and adiposity.
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.023 秒)
