公开(公告)号：US20240307305A1

公开(公告)日：2024-09-19

申请号：US18676396

申请日：2024-05-28

申请人： SINGAPORE HEALTH SERVICES PTE LTD ,  NANYANG TECHNOLOGICAL UNIVERSITY ,  SANTEN PHARMACEUTICAL CO., LTD.

发明人： Donald TAN ,  Roger BEUERMAN ,  Hiroyuki ASADA ,  Kyohei TAKAHASHI ,  Koji SAKANAKA ,  Takashi MORIMOTO ,  Toyomi FUJISAWA

IPC分类号： A61K9/08 ,  A61K9/00 ,  A61K31/46 ,  A61K47/02 ,  A61K47/08 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18 ,  A61K47/38 ,  A61P27/02 ,  A61P27/08 ,  A61P27/10

CPC分类号： A61K9/08 ,  A61K9/0048 ,  A61K31/46 ,  A61K47/02 ,  A61K47/08 ,  A61K47/10 ,  A61K47/12 ,  A61K47/183 ,  A61K47/186 ,  A61K47/38 ,  A61P27/02 ,  A61P27/08 ,  A61P27/10

摘要： Disclosed herein is an aqueous composition comprising 0.001-0.1% (w/v) atropine or a salt thereof, a water-soluble polymer, and buffer (1), which is at a pH range of 6 or lower, wherein the buffer (1) is at least one selected from the group consisting of a phosphate buffer, an aminocarboxylate buffer, a carbonate buffer, an acetate buffer, a tartrate buffer, a borate buffer, and trometamol.

公开(公告)号：US20210267885A1

公开(公告)日：2021-09-02

申请号：US16303686

申请日：2017-05-24

申请人： SINGAPORE HEALTH SERVICES PTEL LTD ,  NANYANG TECHNOLOGICAL UNIVERSITY ,  SANTEN PHARMACEUTICAL CO., LTD.

发明人： Donald TAN ,  Roger BEUERMAN ,  Hiroyuki ASADA ,  Kyohei TAKAHASHI ,  Koji SAKANAKA ,  Takashi MORIMOTO ,  Toyomi FUJISAWA

IPC分类号： A61K9/08 ,  A61K31/46 ,  A61K47/02 ,  A61K47/12 ,  A61K47/10 ,  A61K47/38 ,  A61K47/18 ,  A61K9/00

摘要： Disclosed herein is an aqueous composition comprising 0.001-0.1% (w/v) atropine or a salt thereof, a water-soluble polymer, and buffer (I), which is at a pH range of 6 or lower, wherein the buffer (I) is at least one selected from the group consisting of a phosphate buffer, an aminocarboxylate buffer, a carbonate buffer, an acetate buffer, a tartrate buffer, a borate buffer, and trometamol.

公开(公告)号：US20220281803A1

公开(公告)日：2022-09-08

申请号：US17612013

申请日：2020-05-18

申请人： SINGAPORE HEALTH SERVICES PTE LTD ,  AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ,  TAN TOCK SENG HOSPITAL PTE LTD

发明人： Thet Tun AUNG ,  Jianguo LI ,  Jun Jie KOH ,  Lakshminarayanan RAJAMANI ,  Roger BEUERMAN ,  Tiang Hwee Donald TAN ,  Mercy Halleluyah PERIAYAH ,  Chandra Shekhar VERMA ,  Swaine CHEN ,  Timothy BARKHAM

IPC分类号： C07C217/20 ,  A61P31/04 ,  A61K47/02 ,  C07C279/14 ,  C07D213/30 ,  C07D233/60 ,  C07D405/14

摘要： The present invention relates to a compound comprising a hydrophobic moiety, a linker and N-containing moiety. The present invention also relates to the method of synthesizing the compound and the use of the compound as an antibiotic or an adjuvant for an antibiotic.