公开(公告)号：US20230040275A1

公开(公告)日：2023-02-09

申请号：US17777954

申请日：2020-11-19

Applicant: SPARK THERAPEUTICS, INC.

Inventor： David William ANDERSON ,  Brittney L. GURDA ,  Federico MINGOZZI ,  Mustafa N. YAZICIOGLU ,  William QUINN

IPC: C12N15/62 ,  A61K39/35 ,  A61K39/00 ,  C07K14/705 ,  C12N15/86 ,  A61K48/00 ,  A61P37/06 ,  A61K31/436 ,  C07K14/47 ,  C07K14/005

Abstract: Nucleic acids encoding fusion proteins that contain an unwanted antigen and a leader sequence for cell secretion are described. Also described are expression cassettes, vectors, cells, and cell lines containing the nucleic acids, as well as methods of using the nucleic acids to treat autoimmune, allergic and other diseases and disorders, such as multiple sclerosis.