公开(公告)号：US20200262916A1

公开(公告)日：2020-08-20

申请号：US16791520

申请日：2020-02-14

Applicant: STC. UNM

Inventor： Vojo P. Deretic ,  Yuexi Gu ,  Graham Timmins

IPC: C07K16/28 ,  A61K31/4439 ,  A61K31/5025 ,  A61K31/502 ,  A61K31/53

Abstract: The present invention is directed to the elucidation of the mechanism that human Atg8 protein regulates endolysosomal systems in the cell and the role this protein plays in mediating autophagy. Methods of treating autophagy-mediated disease states with agonists/antagonists of Atg8, STX16 and STX17 proteins are disclosed as are pharmaceutical compositions.