公开(公告)号：US20190120873A1

公开(公告)日：2019-04-25

申请号：US16095011

申请日：2017-04-24

Applicant: STC. UNM

Inventor： Steven R.J. BRUECK ,  Daniel FEEZELL ,  John RANDALL ,  Tito BUSANI ,  Joshua B. BALLARD ,  Mahmoud BEHZADIRAD ,  Ashwin Krishnan RISHINARAMANGALAM

IPC: G01Q60/16 ,  B82B3/00 ,  G01Q70/14 ,  G03F7/00 ,  G01Q70/06 ,  G01Q80/00

Abstract: Provided is a composite metal-wide-bandgap semiconductor tip for scanning tunneling microscopy and/or scanning, tunneling lithography, a method of forming, and a method for using the composite metal-wide-bandgap semiconductor tip.

公开(公告)号：US20190106474A1

公开(公告)日：2019-04-11

申请号：US16039858

申请日：2018-07-19

Applicant: STC. UNM

Inventor： Yubin Miao ,  Haixun Guo

IPC: C07K14/68 ,  C07K7/54 ,  A61K51/08 ,  A61K45/06

CPC classification number: C07K14/68 ,  A61K38/00 ,  A61K45/06 ,  A61K51/08 ,  A61K51/086 ,  A61K51/088 ,  C07K7/54

Abstract: The present invention is directed to novel non-invasive diagnostic tools/compounds to image cancers, especially, melanoma, including metastatic melanoma in vivo. The present compounds exhibit enhanced uptake in cancerous cells and tissue and decreased renal uptake in kidney, evidencing favorable pharmacokinetics of compounds of the present invention. The compounds according to the present invention represent an advance in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention are also useful for initiating therapy for melanoma as well as monitor patients' response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.

公开(公告)号：US10158234B2

公开(公告)日：2018-12-18

申请号：US15112252

申请日：2015-01-16

Applicant: STC. UNM ,  Andrea A. Mammoli ,  Yasser Yasaei

Inventor： Andrea A. Mammoli ,  Yasser Yasaei

IPC: H02J3/38 ,  H02J7/00

Abstract: The present invention is an apparatus and method for using aggregated loads from a plurality of distributed energy resources to perform a function at a power distribution feeder. The invention includes a plurality of distributed energy resources, wherein at least one distributed energy resource includes a renewable energy resource, a communication network, a control device, a power distribution feeder coupled to the control device, and an energy storage system coupled to the power distribution feeder. The control device sends a signal to the plurality of distributed energy resources via the communication network. The signal is a request to switch a status of one or more of the distributed energy resources if one or more distributed energy resources is within a predetermined condition. Loads from the one or more of the distributed energy resources that switched status are aggregated to perform a function at the power distribution feeder.

公开(公告)号：US20170165375A1

公开(公告)日：2017-06-15

申请号：US14781817

申请日：2014-04-02

Applicant: STC. UNM ,  SANDIA CORPORATION

Inventor： Carlee Erin Ashley ,  Eric C. Carnes ,  Terry Wu ,  Linda A. Felton ,  Darryl Y. Sasaki

IPC: A61K9/51 ,  A61K9/50 ,  A61K31/5383 ,  A61K31/65 ,  A61K31/546 ,  A61K31/635 ,  A61K31/505 ,  A61K9/00 ,  A61K9/127 ,  A61K31/7036

CPC classification number: A61K31/7036 ,  A61K9/0053 ,  A61K9/1271 ,  A61K9/1274 ,  A61K9/5021 ,  A61K9/5123 ,  A61K31/505 ,  A61K31/5383 ,  A61K31/546 ,  A61K31/635 ,  A61K31/65 ,  A61K47/52 ,  A61K47/60 ,  A61K47/62 ,  A61K47/68 ,  A61K47/6913 ,  A61K47/6917 ,  A61K47/6923 ,  A61K47/6929 ,  B82Y5/00 ,  Y02A50/404 ,  Y02A50/406 ,  Y02A50/469 ,  Y02A50/471 ,  Y02A50/475 ,  Y02A50/478 ,  Y02A50/481

Abstract: The invention provides novel antibiotic protocells comprising mesoporous nanoparticles encapsulated within a lipid bi- or multilayer. The nanoparticles have pore sizes and surface chemistries that enable facile adsorption and intracellular presentation of antibiotics which are effective in the treatment of a wide variety of bacterial infections, including F. tularensis, B. pseudomallei and P. aeruginosa-related infections. Related pharmaceutical compositions and methods of treatment are also provided.

公开(公告)号：US20160079075A1

公开(公告)日：2016-03-17

申请号：US14785819

申请日：2014-04-24

Applicant: STC. UNM

Inventor： Zayd LESEMAN ,  Khawar ABBAS ,  Joseph BUTNER ,  Mirza ELAHI ,  Denise PINON

IPC: H01L21/3065 ,  H01L21/66 ,  H01L21/67

CPC classification number: H01L21/3065 ,  H01L21/30655 ,  H01L21/67069 ,  H01L21/67253 ,  H01L22/26

Abstract: A method for determining depletion of an etchant, an etch depth, and an etch rate during an etch of a material such as Si using an etchant such as xenon difluoride (XeF2) in a pulsed etching system in real time measuring pressure within a closed system during the etch. Coupling the pressure data with the knowledge of the chemical reactions allows for the determination of the etching parameters of interest. While the etch of Si using XeF2 is used for demonstration, the method may be generalized to any closed volume system provided there is a net change in number of moles of gaseous species present in the system before and after the reaction.

Abstract translation: 在脉冲蚀刻系统中使用诸如氙二氟化物（XeF2）的蚀刻剂蚀刻诸如Si之类的材料的蚀刻深度和蚀刻速率的方法，用于实时测量封闭系统内的压力的方法 在蚀刻期间。 将压力数据与化学反应的知识结合允许确定感兴趣的蚀刻参数。 虽然使用XeF2对Si的蚀刻用于示范，但是如果在反应之前和之后系统中存在的气态物质的摩尔数存在净变化，则该方法可以推广到任何封闭体积系统。

公开(公告)号：US20150108427A1

公开(公告)日：2015-04-23

申请号：US14383833

申请日：2013-03-15

Applicant: STC. UNM

Inventor： Steven R.J. Brueck ,  Seung-Chang Lee ,  Christian Wetzel ,  Theeradetch Detchprohm ,  Christoph Stark

IPC: H01L29/20 ,  H01L21/02 ,  H01L29/15

CPC classification number: H01L29/2003 ,  H01L21/02381 ,  H01L21/02395 ,  H01L21/0243 ,  H01L21/02433 ,  H01L21/02458 ,  H01L21/02494 ,  H01L21/02502 ,  H01L21/0251 ,  H01L21/0254 ,  H01L21/02546 ,  H01L21/02549 ,  H01L21/02587 ,  H01L21/02598 ,  H01L21/02658 ,  H01L29/15 ,  H01L33/16 ,  H01L33/24

Abstract: A semiconductor device is disclosed. The semiconductor device includes a substrate comprising a groove. A buffer layer is formed on a surface of the groove. The buffer layer comprising at least one material chosen from AIN, GaN or AlxGa1-xN, where x is between zero and one. An epitaxially grown semiconductor material is disposed over the buffer layer, at least a portion of the epitaxially grown semiconductor material having a cubic crystalline phase structure. Methods of forming the semiconductor devices are also taught.

Abstract translation: 公开了一种半导体器件。 半导体器件包括包括沟槽的衬底。 在槽的表面上形成缓冲层。 所述缓冲层包含至少一种选自AIN，GaN或Al x Ga 1-x N的材料，其中x在0和1之间。 外延生长的半导体材料设置在缓冲层之上，至少部分外延生长的半导体材料具有立方晶相结构。 还教导了形成半导体器件的方法。

公开(公告)号：US20130178536A1

公开(公告)日：2013-07-11

申请号：US13744719

申请日：2013-01-18

Applicant: STC. UNM

Inventor： David L. Vander Jagt ,  Lorraine M. Deck ,  Robert E. Royer ,  John E. Heidrich ,  Laurel O. Sillerud

IPC: A61K31/136 ,  A61K31/05 ,  A61K31/085

CPC classification number: A61K31/136 ,  A61K31/05 ,  A61K31/085 ,  A61K31/381 ,  A61K31/44 ,  A61K31/525 ,  A61K31/66 ,  C07D213/30 ,  C07D333/16

Abstract: The present invention relates to method(s) of treating a subject afflicted with cancer or a precancerous condition, an inflammatory disease or condition, and/or stroke or other ischemic disease or condition, the method comprising administering to the subject or patient in need a composition comprising a therapeutically effective amount of a substituted cis or trans-stilbene. A method of treating or reducing the likelihood of Alzheimer's disease in a patient is an additional embodiment of the present invention.

Abstract translation: 本发明涉及治疗患有癌症或癌前病症，炎性疾病或病症，和/或中风或其他缺血性疾病或病症的受试者的方法，所述方法包括对需要的受试者或患者施用 组合物，其包含治疗有效量的取代的顺式或反式二苯乙烯。 治疗或降低患者中阿尔茨海默氏病的可能性的方法是本发明的另外的实施方案。

公开(公告)号：US20180221382A1

公开(公告)日：2018-08-09

申请号：US15506421

申请日：2015-08-21

Applicant: STC UNM

Inventor： Ellen Janine Beswick

IPC: A61K31/553 ,  A61K31/165 ,  A61K31/551 ,  A61K31/4709 ,  A61K31/496 ,  A61K38/00 ,  A61K45/06 ,  A61P35/00

CPC classification number: A61K31/553 ,  A61K31/165 ,  A61K31/167 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/551 ,  A61K38/005 ,  A61K45/06 ,  A61K2300/00 ,  A61P35/00

Abstract: The present invention relates to the discovery that MK2 is highly expressed in cancer tissue and the inhibition of MK2 using an MK2 inhibitor represents a viable approach to the treatment of cancer, including drug resistant cancers, metastatic cancers and recurrent cancers. MK2 inhibitors as described herein may be used alone or in combination with an at least one additional anti-cancer agent for the treatment of cancer.

公开(公告)号：US09823486B2

公开(公告)日：2017-11-21

申请号：US15133054

申请日：2016-04-19

Applicant: STC. UNM

Inventor： Sudhakar Prasad

IPC: G02B27/58 ,  G01C11/02 ,  G02B5/30 ,  G02B5/18 ,  G02B21/36 ,  G02B27/26 ,  G02B27/00

CPC classification number: G02B27/58 ,  G01B11/002 ,  G01C11/02 ,  G02B5/189 ,  G02B5/3083 ,  G02B21/36 ,  G02B21/361 ,  G02B27/0075 ,  G02B27/26

Abstract: An optical imaging system having an aperture comprised of a plurality of concentric annuli. The outer radius of each annulus is proportional to the square root of the number of annuli. Each annulus also having an azimuthally linearly increasing phase profile comprising for a given light wavelength. The system also includes a birefringent plate and the aperture and birefringent plate are adapted to jointly encode the full spatial and polarimetric degrees of freedom of a point source.

公开(公告)号：US20150293004A1

公开(公告)日：2015-10-15

申请号：US14545590

申请日：2015-05-27

Applicant: STC. UNM ,  Senior Scientific, LLC

Inventor： Natalie L. Adolphi ,  Edward R. Flynn ,  Howard Bryant ,  Kimberly Butler

IPC: G01N11/12

CPC classification number: G01N11/12 ,  B82Y15/00 ,  G01N2011/0086

Abstract: A method for measuring the average viscosity of a test fluid uses calibrated magnetic nanoparticles, with certain chosen hydrodynamic diameters and actual lateral dimensions (e.g. diameters), that are mixed into a small volume of the test fluid and a single magnetic relaxation curve measurement to provide data for viscosity determination. The distribution of hydrodynamic particle sizes of an ensemble of magnetic nanoparticles that are magnetically blocked at room temperature can be determined. Modifications of the method can be used to determine the distribution of viscosities in a complex fluid at the sub-microscopic level providing a novel type of viscosity measurement.

Abstract translation: 用于测量测试流体的平均粘度的方法使用校准的磁性纳米颗粒，其具有某些选定的流体动力学直径和实际横向尺寸（例如直径），其被混合到小体积的测试流体中，并且提供单个磁弛张曲线测量值以提供 粘度测定数据。 可以确定在室温下磁性阻断的磁性纳米颗粒组的流体动力学粒径的分布。 该方法的修改可以用于确定在亚微观水平的复杂流体中的粘度分布，提供新型粘度测量。