公开(公告)号：US20170296108A1

公开(公告)日：2017-10-19

申请号：US15489828

申请日：2017-04-18

Applicant: STC.UNM

Inventor： John B. Plumley ,  Erin D. Milligan ,  Marek Osinski

IPC: A61B5/1455 ,  A61B5/00 ,  A61B5/1459 ,  G01N33/58 ,  A61B5/1473

CPC classification number: A61B5/1455 ,  A61B5/1459 ,  A61B5/14735 ,  A61B5/4058 ,  A61B5/6852 ,  A61B5/6877 ,  A61B2562/0233 ,  A61B2562/0285 ,  G01N33/588

Abstract: The invention provides a quantum dot (QD) modified optical fiber-based biosensor which characterizes matrix metalloproteinase (MMP) enzyme activity at pain signaling sites in the central nervous system (CNS) in vivo. Related systems and peptide biomarker screening methods are also provided.

公开(公告)号：US10299707B2

公开(公告)日：2019-05-28

申请号：US15489828

申请日：2017-04-18

Applicant: STC.UNM

Inventor： John B. Plumley ,  Erin D. Milligan ,  Marek Osinski

IPC: A61B5/1455 ,  G01N33/58 ,  A61B5/1459 ,  A61B5/00 ,  A61B5/1473

Abstract: The invention provides a quantum dot (QD) modified optical fiber-based biosensor which characterizes matrix metalloproteinase (MMP) enzyme activity at pain signaling sites in the central nervous system (CNS) in vivo. Related systems and peptide biomarker screening methods are also provided.

公开(公告)号：US09655553B2

公开(公告)日：2017-05-23

申请号：US14850221

申请日：2015-09-10

Applicant: STC.UNM

Inventor： John B. Plumley ,  Erin D. Milligan ,  Marek Osinski

IPC: A61B5/1455 ,  G01N33/58 ,  A61B5/1459 ,  A61B5/00 ,  A61B5/1473

CPC classification number: A61B5/1455 ,  A61B5/1459 ,  A61B5/14735 ,  A61B5/4058 ,  A61B5/6852 ,  A61B5/6877 ,  A61B2562/0233 ,  A61B2562/0285 ,  G01N33/588

Abstract: The invention provides a quantum dot (QD) modified optical fiber-based biosensor which characterizes matrix metalloproteinase (MMP) enzyme activity at pain signaling sites in the central nervous system (CNS) in vivo. Related systems and peptide biomarker screening methods are also provided.