公开(公告)号：US09605344B2

公开(公告)日：2017-03-28

申请号：US14917566

申请日：2014-09-12

Applicant: STC.UNM

Inventor： Ying-Bing Jiang ,  Joseph L. Cecchi ,  Yaqin Fu ,  C. Jeffrey Brinker

IPC: C23C16/455 ,  C23C16/46

CPC classification number: C23C16/45525 ,  C23C16/45534 ,  C23C16/46

Abstract: An atomic layer deposition method is disclosed for preparing polypeptides. The method comprises providing a solid-phase support comprising a reactive amine monolayer in an atomic layer deposition (ALD) chamber. The solid-phase support is contacted with a first protected amino acid substituted with a protecting group by atomic layer deposition, wherein the protecting group is bonded to a non-side chain amino group of the protected amino acid. A carboxylic acid group of the first protected amino acid is reacted with the reactive amine monolayer, thereby coupling the first protected amino acid to the solid-phase support to produce a coupled-product.