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1.发明授权Rationally improved isoniazid and ethionamide derivatives and activity through selective isotopic substitution 有权通过选择性同位素替代，合理改善异烟肼和乙硫异烟酰胺衍生物和活性公开(公告)号：US08921569B2
公开(公告)日：2014-12-30
申请号：US13760605
申请日：2013-02-06
Applicant: STC.UNM , Johns Hopkins University
Inventor： Graham Timmins , Sharon Master , Vojo P Deretic , William Bishai
IPC: C07D213/86 , A61K9/00 , C07D213/81 , C07D213/83 , A61K31/44 , A61K31/4409
CPC classification number: C07D213/81 , A61K9/0019 , A61K9/0073 , A61K31/44 , A61K31/4409 , C07D213/83 , C07D213/86
Abstract: The present invention relates to the use of isotopically labeled derivatives of isoniazid, ethionamide and related compounds as effective therapy for the treatment of mycobacterial diseases, including Mycobacterium tuberculosis.
Abstract translation: 本发明涉及异烟肼，乙硫异烟胺和相关化合物的同位素标记衍生物在治疗分枝杆菌疾病（包括结核分枝杆菌）中的有效疗法。
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