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公开(公告)号：US20230285356A1
公开(公告)日：2023-09-14
申请号：US17977920
申请日：2022-10-31
Applicant: Sunovion Pharmaceuticals Inc.
Abstract: Provided are compositions comprising unequal mixtures of (R)-amisulpride and (S)-amisulpride, or pharmaceutically acceptable salts thereof, where the amount of (R)-amisulpride is greater than the amount of (S)-amisulpride, compositions and medicaments comprising the same used for the treatment of various diseases and disorders, and methods of using same for the treatment of various diseases and disorders, including, but not limited to, dosage regimens. In addition, provided are various formulations thereof, including, but not limited to, formulations employing polymorphs of enantiomeric amisulpride.
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公开(公告)号：US20210315860A1
公开(公告)日：2021-10-14
申请号：US17097799
申请日：2020-11-13
Applicant: Sunovion Pharmaceuticals Inc.
Abstract: Provided are compositions comprising unequal mixtures of (R)-amisulpride and (S)-amisulpride, or pharmaceutically acceptable salts thereof, where the amount of (R)-amisulpride is greater than the amount of (S)-amisulpride, compositions and medicaments comprising the same used for the treatment of various diseases and disorders, and methods of using same for the treatment of various diseases and disorders, including, but not limited to, dosage regimens. In addition, provided are various formulations thereof, including, but not limited to, formulations employing polymorphs of enantiomeric amisulpride.
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公开(公告)号：US20200165200A1
公开(公告)日：2020-05-28
申请号：US16749744
申请日：2020-01-22
Applicant: Sunovion Pharmaceuticals Inc.
Inventor： John R. Snoonian , Harold Scott Wilkinson
IPC: C07D207/09
Abstract: The various aspects present inventions provide various crystalline forms of (S)-(−)-amisulpride, (R)-(+)-amisulpride, and solvates thereof and methods of making same. In various aspects, the inventions also provide methods of resolving racemic amisulpride.
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公开(公告)号：US20190256525A1
公开(公告)日：2019-08-22
申请号：US16277443
申请日：2019-02-15
Applicant: Sunovion Pharmaceuticals Inc.
Inventor： Andrea Bauer , Nandkumar Nivritti Bhogle , Xiaoxia Chen , Shahla Jamzad , Robert Joseph Prytko , Kostas Saranteas , Harold Scott Wilkinson , Haitao Zhang
IPC: C07D495/04 , A61P25/18 , A61K9/20
Abstract: Provided are salts of (S)-(4,5-dihydro-7H-thieno[2,3-c]pyran-7-yl)-N-methylmethanamine and various of crystal forms thereof, and compositions, medicaments, pharmaceutically acceptable formulations thereof, and methods of making same. In addition, provided are compounds comprising specific particle size distributions of crystalline (S)-(4,5-dihydro-7H-thieno[2,3-c]pyran-7-yl)-N-methylmethanamine HCl and methods of making and modulating the particle size distributions.
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公开(公告)号：US10800738B2
公开(公告)日：2020-10-13
申请号：US16749744
申请日：2020-01-22
Applicant: Sunovion Pharmaceuticals Inc.
Inventor： John R. Snoonian , Harold Scott Wilkinson , Haitao Zhang
IPC: C07D207/09
Abstract: The various aspects present inventions provide various crystalline forms of (S)-(−)-amisulpride, (R)-(+)-amisulpride, and solvates thereof and methods of making same. In various aspects, the inventions also provide methods of resolving racemic amisulpride.
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Patent Agency Ranking
公开(公告)号：US10576058B2
公开(公告)日：2020-03-03
申请号：US16452880
申请日：2019-06-26
Applicant: Sunovion Pharmaceuticals Inc.
Abstract: Provided are compositions comprising unequal mixtures of (R)-amisulpride and (S)-amisulpride, or pharmaceutically acceptable salts thereof, where the amount of (R)-amisulpride is greater than the amount of (S)-amisulpride, compositions and medicaments comprising the same used for the treatment of various diseases and disorders, and methods of using same for the treatment of various diseases and disorders, including, but not limited to, dosage regimens. In addition, provided are various formulations thereof, including, but not limited to, formulations employing polymorphs of enantiomeric amisulpride.
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7.发明申请公开(公告)号：US20150196502A1
公开(公告)日：2015-07-16
申请号：US14605334
申请日：2015-01-26
Applicant: SUNOVION PHARMACEUTICALS INC.
Inventor： Sharon M. LAUGHLIN , Michael J. Sizensky , Surendra P. Singh , Harold Scott Wilkinson , Cai Gu Huang , Philip James Bonasia , Susan S. D'souza
IPC: A61K31/135
CPC classification number: A61K31/135 , A61K9/2018 , A61K9/4858 , C07C211/42
Abstract: Provided herein are pharmaceutical compositions comprising transnorsertraline, salts and polymorphic forms of transnorsertraline, methods of making the compositions, and methods for their use for the treatment of CNS diseases, including depression.
Abstract translation: 本文提供的药物组合物包含过度心律，盐和多形态的跨屈曲胆碱，制备组合物的方法，及其用于治疗包括抑郁症在内的CNS疾病的方法。
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公开(公告)号：US20230072389A1
公开(公告)日：2023-03-09
申请号：US17748165
申请日：2022-05-19
Applicant: Sunovion Pharmaceuticals Inc.
Inventor： John R. Snoonian , Harold Scott Wilkinson , Haitao Zhang
IPC: C07D207/09
Abstract: The various aspects present inventions provide various crystalline forms of (S)-(−)-amisulpride, (R)-(+)-amisulpride, and solvates thereof and methods of making same. In various aspects, the inventions also provide methods of resolving racemic amisulpride.
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公开(公告)号：US11066380B2
公开(公告)日：2021-07-20
申请号：US16817749
申请日：2020-03-13
Applicant: Sunovion Pharmaceuticals Inc.
Inventor： Nandkumar Nivritti Bhogle , Takahiko Hashizuka , Robert Joseph Prytko , John R. Snoonian , Harold Scott Wilkinson , Haitao Zhang
IPC: C07D311/76
Abstract: The present disclosure relates to salts of (R)-1-(8-fluoroisochroman-1-yl)-N-methylmethanamine, crystalline forms thereof, and methods of preparation thereof, which are useful in the treatment of CNS disorders.
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公开(公告)号：US10577317B2
公开(公告)日：2020-03-03
申请号：US16449103
申请日：2019-06-21
Applicant: Sunovion Pharmaceuticals Inc.
Inventor： John R. Snoonian , Harold Scott Wilkinson
IPC: C07D207/09
Abstract: The various aspects present inventions provide various crystalline forms of (S)-(−)-amisulpride, (R)-(+)-amisulpride, and solvates thereof and methods of making same. In various aspects, the inventions also provide methods of resolving racemic amisulpride.
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