公开(公告)号：US09114086B2

公开(公告)日：2015-08-25

申请号：US14243146

申请日：2014-04-02

Applicant: Sunovion Pharmaceuticals Inc.

Inventor： Richard Hsia ,  Cai Gu Huang ,  Konstantinos E. Saranteas ,  Tushar K. Misra ,  Philip J. Bonasia, Jr.

IPC: A61K9/20 ,  A61K9/30 ,  A61K31/4985 ,  A61K9/28

CPC classification number: A61K9/2866 ,  A61K31/4985 ,  Y10T436/147777

Abstract: Coated tablets of (6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine) are provided. The tablets minimize the perceived bitterness of the medicament. A method for analyzing instantaneous dissolution of sub-microgram quantities of core material is also disclosed.

Abstract translation: （6-（5-氯-2-吡啶基）-5 - [（4-甲基-1-哌嗪基）羰氧基] -7-氧代-6,7-二氢-5H-吡咯并[3,4-b ]吡嗪）。 片剂使药物的感觉到的苦味最小化。 还公开了一种用于分析亚微米数量的芯材料的瞬时溶解的方法。

公开(公告)号：US20150196502A1

公开(公告)日：2015-07-16

申请号：US14605334

申请日：2015-01-26

Applicant: SUNOVION PHARMACEUTICALS INC.

Inventor： Sharon M. LAUGHLIN ,  Michael J. Sizensky ,  Surendra P. Singh ,  Harold Scott Wilkinson ,  Cai Gu Huang ,  Philip James Bonasia ,  Susan S. D'souza

IPC: A61K31/135

CPC classification number: A61K31/135 ,  A61K9/2018 ,  A61K9/4858 ,  C07C211/42

Abstract: Provided herein are pharmaceutical compositions comprising transnorsertraline, salts and polymorphic forms of transnorsertraline, methods of making the compositions, and methods for their use for the treatment of CNS diseases, including depression.

Abstract translation: 本文提供的药物组合物包含过度心律，盐和多形态的跨屈曲胆碱，制备组合物的方法，及其用于治疗包括抑郁症在内的CNS疾病的方法。

公开(公告)号：US20180071230A1

公开(公告)日：2018-03-15

申请号：US15631909

申请日：2017-06-23

Applicant: SUNOVION PHARMACEUTICALS INC.

Inventor： Sharon M. Laughlin ,  Michael J. Sizensky ,  Surendra P. Singh ,  Harold Scott Wilkinson ,  Cai Gu Huang ,  Philip James Bonasia ,  Susan S. D'Souza

IPC: A61K31/135 ,  C07C211/42 ,  A61K9/20 ,  A61K9/48

CPC classification number: A61K31/135 ,  A61K9/2018 ,  A61K9/4858 ,  C07C211/42

Abstract: Provided herein are pharmaceutical compositions comprising transnorsertraline, salts and polymorphic forms of transnorsertraline, methods of making the compositions, and methods for their use for the treatment of CNS diseases, including depression.