公开(公告)号：US10087126B2

公开(公告)日：2018-10-02

申请号：US15516110

申请日：2015-10-08

Applicant: SYNGENTA PARTICIPATIONS AG

Inventor： Helmars Smits ,  Paul Knochel ,  Thomas Klatt ,  Matthias Becker

IPC: C07C17/25 ,  C07C17/383 ,  C07C17/35 ,  C07C17/38 ,  C07C17/013

Abstract: The invention relates to a process for the preparation of compound of formula (I) wherein R1 is halogen and R2 is halogen or hydrogen; comprising a) reacting the compound of formula (II) in an aprotic organic solvent in the presence of an aprotic polar co-solvent with a magnesium amide base followed by a halogenating agent, to the compound of formula I wherein R1 is halogen and R2 is hydrogen, and b) reacting the compound of formula (I), wherein R1 is chloro and R2 is hydrogen, in an aprotic organic solvent in the presence of an aprotic polar co-solvent with a magnesium amide base followed by a halogenating agent to a compound of formula I, wherein R1 is chloro and R2 is halogen.