公开(公告)号：US20150024414A1

公开(公告)日：2015-01-22

申请号：US14157378

申请日：2014-01-16

Applicant: Sandia Corporation

Inventor： Jason C. Harper ,  Thayne L. Edwards ,  Bryan Carson ,  Melissa Finley ,  William Arndt

IPC: G01N33/569

CPC classification number: G01N33/56911 ,  B01L3/502738 ,  B01L2300/0663 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2400/0406 ,  B01L2400/0633 ,  F16K31/086 ,  F16K99/003 ,  F16K99/0046 ,  F16K2099/0084 ,  Y10T137/87917

Abstract: The present invention, in part, relates to methods and apparatuses for on-chip amplification and/or detection of various targets, including biological targets and any amplifiable targets. In some examples, the microculture apparatus includes a single-use, normally-closed fluidic valve that is initially maintained in the closed position by a valve element bonded to an adhesive coating. The valve is opened using a magnetic force. The valve element includes a magnetic material or metal. Such apparatuses and methods are useful for in-field or real-time detection of targets, especially in limited resource settings.

Abstract translation: 本发明部分地涉及用于片上放大和/或检测各种靶标的方法和装置，包括生物靶标和任何可扩增的靶标。 在一些实例中，微培养装置包括一次性常闭的流体阀，其最初通过结合到粘合剂涂层的阀元件保持在关闭位置。 阀门使用磁力打开。 阀元件包括磁性材料或金属。 这样的设备和方法对于现场或实时检测目标是有用的，特别是在有限的资源设置中。