公开(公告)号：US20240342707A1

公开(公告)日：2024-10-17

申请号：US18292527

申请日：2022-07-19

申请人： CARL ZEISS MICROSCOPY GMBH

发明人： Horst Wolff ,  Rebecca Elsaesser

IPC分类号： B01L3/00

CPC分类号： B01L3/502715 ,  B01L2200/0647 ,  B01L2200/16 ,  B01L2300/0663 ,  B01L2300/0681

摘要： The disclosure relates to a sample carrier, the use thereof, and methods, in particular for detecting pathogens. The sample carrier has a sample chamber for receiving a sample, which chamber is enclosed by a wall, and an access opening for filling the sample chamber with the sample; the wall has at least one region which is transparent to detection radiation coming from the sample and acts as a detection window. According to the invention, the sample chamber has, in a direction perpendicular to the transparent region of the wall, a clear distance between the opposing inner faces of the wall of at most 50 μm, in particular, at most 25 μm.

公开(公告)号：US12111236B2

公开(公告)日：2024-10-08

申请号：US18177696

申请日：2023-03-02

申请人： Assure Tech. (Hangzhou) Co., Ltd

发明人： Shi sheng Ling

IPC分类号： B01L3/00 ,  G01N1/14

CPC分类号： G01N1/14 ,  B01L3/502 ,  B01L2300/025 ,  B01L2300/0663 ,  B01L2300/069 ,  B01L2300/0832

摘要： A sample collection and detection device includes a collection cavity. The device further includes a sample collector. The sample collector comprises a collection rod and an absorption element, and the absorption element has a hollow cavity. A part of the collection rod is received in the hollow cavity of the absorption element. A first lug for blocking and locating the absorption element is arranged on the collection rod. Also provided is a method for collecting and detecting sample using the sample collection and detection device.

公开(公告)号：US12109563B2

公开(公告)日：2024-10-08

申请号：US17309918

申请日：2020-09-29

申请人： ILLUMINA SINGAPORE PTE. LTD.

发明人： Beng Keong Ang ,  Shyun Long Wang ,  Heng Kuang Cheng ,  Chow Jin Chng ,  Ai Wee Lee ,  Yashwanth Panduga

IPC分类号： B01L3/00 ,  B01L7/00 ,  G01N35/10

CPC分类号： B01L3/502738 ,  B01L7/00 ,  G01N35/1097 ,  B01L2300/0663 ,  B01L2400/0644

摘要： A test cartridge for insertion into an analysis instrument having an actuation mechanism, the test cartridge having one or more sensors for measuring an aspect of the actuation mechanism.

公开(公告)号：US12097499B2

公开(公告)日：2024-09-24

申请号：US18151011

申请日：2023-01-06

申请人： Tokitae LLC

发明人： Toan Huynh ,  Bernhard Hans Weigl ,  Samantha A. Byrnes ,  Kevin Paul Flood Nichols

IPC分类号： B01L3/00 ,  B01F23/00 ,  B01F23/41 ,  B01F101/23 ,  B23Q17/24 ,  C12M1/34 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/6816 ,  C12Q1/686 ,  C23C2/00 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/39 ,  G01N21/45 ,  G01N21/64 ,  G01N30/12 ,  G01N30/68 ,  G01N30/70 ,  G01N30/72 ,  G01N30/88 ,  G01N33/00 ,  G01N33/18 ,  G01N33/50 ,  G01N33/543 ,  G01N33/68 ,  G01N35/04 ,  G01N35/10

CPC分类号： B01L3/5082 ,  C12Q1/6816 ,  C23C2/51 ,  B01L2200/18 ,  B01L2300/0663 ,  B01L2300/0832 ,  B01L2400/0433 ,  G01N33/18

摘要： An embodiment of a system includes a compartment-generating device, a compartment detector, and electronic computing circuitry. The device is configured to generate compartments of a digital assay, at least one of the compartments having a respective volume that is different from a respective volume of each of at least another one of the compartments. The detector is configured to determine a number of the compartments each having a respective number of a target that is greater than a threshold number of the target. And the electronic circuitry is configured to determine a bulk concentration of the target in a source of the sample in response to the determined number of compartments. Because such a system can be configured to estimate a bulk concentration of a target in a source from a polydisperse digital assay, the system can be portable, and lower-cost and faster, than conventional systems.

公开(公告)号：US12089936B2

公开(公告)日：2024-09-17

申请号：US17571080

申请日：2022-01-07

申请人： CCQCC Corp.

发明人： George S. Cembrowski

IPC分类号： A61B5/15 ,  A61B5/153 ,  A61B5/157 ,  A61M1/36 ,  B01L3/00 ,  G01N33/49

CPC分类号： A61B5/150809 ,  A61B5/1405 ,  A61B5/15003 ,  A61B5/150351 ,  A61B5/150755 ,  A61B5/150786 ,  A61B5/15087 ,  A61B5/153 ,  A61B5/157 ,  A61M1/3633 ,  B01L3/5082 ,  B01L2300/021 ,  B01L2300/042 ,  B01L2300/0663 ,  G01N33/49

摘要： A method for inversion counting or phlebotomist monitoring can include identifying, by processing circuitry, whether a blood collection tube is present in image data from a camera situated to capture images of a phlebotomist collecting a sample, in response to identifying the blood collection tube is present in the field of view of the camera based on the image data, identifying whether the blood collection tube includes blood therein, after identifying the blood is present in the blood collection tube, counting, based on the image data, a number of inversions performed on the blood collection tube, and in response to determining the number of inversions performed is less than a required number of inversions, issuing an alert indicating that insufficient inversions were performed.

公开(公告)号：US20240301470A1

公开(公告)日：2024-09-12

申请号：US18673493

申请日：2024-05-24

申请人： FUJIFILM Corporation

发明人： Takeshi HAMA

IPC分类号： C12Q1/6809 ,  B01L3/00 ,  C12N15/10 ,  C12Q1/686

CPC分类号： C12Q1/6809 ,  B01L3/502753 ,  C12N15/1017 ,  C12Q1/686 ,  B01L2200/16 ,  B01L2300/042 ,  B01L2300/047 ,  B01L2300/0663 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0877 ,  B01L2400/0487

摘要： The nucleic acid examination method includes an extraction step of extracting a nucleic acid from a specimen, a purification step of removing impurities in a liquid of any of a solution containing the specimen or a nucleic acid extraction liquid from which the nucleic acid has been extracted, at any stage before, during, or after the extraction step, an amplification step of amplifying a base sequence in the nucleic acid extraction liquid, a detection step of detecting presence or absence of the base sequence after the amplification step. The extraction step is a step of bringing the specimen into contact with an extraction reagent containing a nonionic surfactant, and the purification step includes an adsorption step of bringing a liquid into contact with a zeolite having any crystal structure of a ferrierite, a mordenite, an L-type, or a Y-type, to adsorb impurities in the liquid to the zeolite.

公开(公告)号：US20240278240A1

公开(公告)日：2024-08-22

申请号：US18632183

申请日：2024-04-10

申请人： Cytek Biosciences, Inc.

发明人： Glen Krueger ,  David Vrane ,  Kuncheng Wang ,  Qiuta Gu

IPC分类号： B01L3/00 ,  C12M1/00 ,  G01N15/01 ,  G01N15/10 ,  G01N15/14 ,  G01N15/1409 ,  G01N15/1434 ,  G01N15/149

CPC分类号： B01L3/502761 ,  B01L3/502715 ,  C12M47/04 ,  G01N15/14 ,  G01N15/1436 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/0681 ,  B01L2300/0829 ,  B01L2300/1805 ,  B01L2300/1894 ,  G01N15/01 ,  G01N2015/1006 ,  G01N2015/1028 ,  G01N15/1409 ,  G01N15/149

摘要： Methods for a sorting flow cytometer system are disclosed. The method includes forming a stream of a sample biological fluid; charging the stream of the sample biological fluid with a first voltage having a first voltage polarity; breaking a first charged drop off of the stream, wherein the first charged drop is charged with the first voltage; dropping the first charged drop between a first electrostatic charge plate and a second electrostatic charge plate opposite the first electrostatic charge plate, wherein the first electrostatic charge plate and the second electrostatic charge plate are positioned on an angle to form a progressively larger gap between each; deflecting the first charged drop off of a center stream path towards the first electrostatic charge plate to drop along a line with a first angle; and orienting a first pivotal scupper to allow the first charged drop to fall into a first test tube.

公开(公告)号：US12066368B2

公开(公告)日：2024-08-20

申请号：US17503086

申请日：2021-10-15

申请人： Robert R. Alfano ,  Lingyan Shi ,  Binlin Wu

发明人： Robert R. Alfano ,  Lingyan Shi ,  Binlin Wu

IPC分类号： G01N15/06 ,  B01L3/00 ,  G01N15/00 ,  G01N15/01 ,  G01N15/075

CPC分类号： G01N15/0612 ,  B01L3/508 ,  B01L2200/025 ,  B01L2300/0609 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/168 ,  G01N15/01 ,  G01N15/075

摘要： A Compact Optical Virus Detection Analyzer (COVDA) uses light scattering and fluorescence to detect nanometer (nm) and micrometer (um) sized particles, such as biological particles and can be used to detect viruses such as coronavirus including SAR-CoV-2 responsible for COVID-19, pollen and bacteria. It can be used for prescreening, rapid detection of suspicious people. COVDA involves experimental and theoretical methods for particle and virus detection using Tryptophan as a key biomarker. Light sources in compact units include lamps such as Xenon (Xe) lamp with narrow band filters, LEDs (such as AlN) or laser diode, Q switched and mode lock Lasers for nanosecond and picosecond pulses (such as Nd Yag/Glass, Ti sapphire with Harmonic generator) in blue from 400 nm to 500 nm to generate second harmonic generation (SHG) in KDP/BBO crystals to produce 200 nm to 250 nm emission, or green laser pointers at about 530 nm to get emitters with harmonic crystals at about 270 nm or LEDS from 230 nm to 300 nm for pumping the samples at 230 nm to 289 nm to pump tryptophan and light scatter of nanometer particles of virus. The ultra high power ns and ps lasers in mJ to J can level can be used to locate Bio virus bacteria clouds in free space to image and destroy and kill virus.

公开(公告)号：US20240264085A1

公开(公告)日：2024-08-08

申请号：US18617770

申请日：2024-03-27

申请人： Meso Scale Technologies, LLC.

发明人： Charles M. CLINTON ,  Jacob N. WOHLSTADTER

IPC分类号： G01N21/76 ,  B01L3/00 ,  G01N21/64 ,  G01N33/543

CPC分类号： G01N21/76 ,  B01L3/502 ,  G01N21/6452 ,  G01N33/54366 ,  B01L2200/025 ,  B01L2200/18 ,  B01L2300/021 ,  B01L2300/0609 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/0829 ,  B01L2300/0867 ,  G01N2201/068 ,  G01N2201/12

摘要： We describe a detection module useful with an apparatus and/or system for conducting luminescence assays, and a kit, a system, an apparatus, and a method incorporating the detection module.

公开(公告)号：US12031974B2

公开(公告)日：2024-07-09

申请号：US17260487

申请日：2020-09-01

申请人： APEL CO., LTD.

发明人： Mitsuru Kashiwada ,  Akira Takayama ,  Yasuichi Haga

IPC分类号： G01N33/49 ,  B01L3/00

CPC分类号： G01N33/4905 ,  B01L3/50273 ,  B01L3/502715 ,  B01L2300/0663 ,  B01L2300/0816 ,  B01L2400/049

摘要： A blood clotting time measurement cartridge that can keep an amount of blood constant while simplifying a configuration and easing a blood injection operation, and a blood clotting time measuring device using the cartridge. The cartridge includes a measurement flow channel wherein blood is housed and transmission of light detects whether there is blood in a predetermined position, an introduction opening on one end side of the channel from which blood is introduced, a communication opening on the other end through which it is possible to cause, by suction or pressurization of air or blood introduced from the introduction opening, the blood in the channel to make a reciprocating motion so as to pass through the predetermined position, a partition wall that partitions a blood injection space connected to the introduction opening, and an absorption member on an outer side of the partition wall that absorbs blood beyond the wall.