公开(公告)号：US20110224304A1

公开(公告)日：2011-09-15

申请号：US13129394

申请日：2009-11-13

申请人： Seiji Iwama ,  Tomoyuki Tanaka ,  Nana Najima

发明人： Seiji Iwama ,  Tomoyuki Tanaka ,  Nana Najima

IPC分类号： A61K31/165 ,  C07C233/05 ,  A61P25/08 ,  A61P25/00

CPC分类号： C07C235/34 ,  C07C233/11 ,  C07C255/57 ,  C07C317/44 ,  C07C323/62 ,  C07C2601/02

摘要： The present invention provides a compound of formula (I) or a salt thereof, wherein R1, R2 and R3 are independently selected from the group consisting of hydrogen atom, fluorine atom, chlorine atom, bromine atom, C1-6 alkyl, C1-6 alkoxy substituted with fluorine atom, and others; R4 and R5 are independently selected from the group consisting of hydrogen atom, fluorine atom, chlorine atom, C1-6 alkyl, C1-6 alkoxy substituted with fluorine atom, and others; R6 and R7 are independently selected from the group consisting of hydrogen atom, fluorine atom, methyl, ethyl, hydroxy group, and others; and R8 and R9 are independently selected from the group consisting of hydrogen atom, C1-6 alkyl, and others, which is useful as an agent for treating or preventing various types of epilepsy including partial seizures and/or generalized seizures.

摘要翻译： 本发明提供式（I）化合物或其盐，其中R 1，R 2和R 3独立地选自氢原子，氟原子，氯原子，溴原子，C 1-6烷基，C 1-6 氟原子取代的烷氧基等; R4和R5独立地选自氢原子，氟原子，氯原子，C1-6烷基，被氟原子取代的C1-6烷氧基等; R6和R7独立地选自氢原子，氟原子，甲基，乙基，羟基等; R8和R9独立地选自氢原子，C1-6烷基等，其可用作治疗或预防各种类型癫痫的药物，包括部分发作和/或全身性发作。