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公开(公告)号：US08420615B2
公开(公告)日：2013-04-16
申请号：US12565151
申请日：2009-09-23
申请人： Sudhir Agrawal , Ekambar Kandimalla , Dong Yu
发明人： Sudhir Agrawal , Ekambar Kandimalla , Dong Yu
CPC分类号： A61K31/711 , A61K38/2013 , A61K39/39 , A61K2039/55561 , A61N2005/1098 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12N2310/318 , C12N2310/334 , C12N2310/336 , C12N2310/3519 , A61K2300/00
摘要： The invention provides an immunostimulatory nucleic acid. In certain embodiments according to this aspect of the invention, the sequence of the immunostimulatory oligonucleotide and/or immunomer is at least partially self-complementary.
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2.发明授权Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response 有权免疫调节寡核苷酸（IRO）化合物调节基于类似受体的免疫应答公开(公告)号：US08399423B2
公开(公告)日：2013-03-19
申请号：US12244199
申请日：2008-10-02
申请人： Ekambar Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
发明人： Ekambar Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
CPC分类号： A61K48/00 , A61K31/711 , A61K39/12 , A61K2039/55561 , C12N2730/10134 , C12N2740/16011 , A61K2300/00
摘要： The invention provides the use of immune regulatory oligonucleotides (IRO) as antagonist of TLRs in the prevention and treatment of a disease caused by a pathogen, for example, a DNA or RNA virus.
摘要翻译： 本发明提供免疫调节寡核苷酸（IRO）作为TLR拮抗剂在预防和治疗由病原体例如DNA或RNA病毒引起的疾病中的用途。
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公开(公告)号：US08383598B2
公开(公告)日：2013-02-26
申请号：US12140338
申请日：2008-06-17
申请人： Ekambar Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
发明人： Ekambar Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
CPC分类号： A61K48/00 , A61K31/7052 , A61K2039/55561 , Y02A50/414
摘要： The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.
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4.发明授权Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides 失效包含修饰的免疫刺激二核苷酸的基于寡核苷酸的化合物的免疫刺激性质公开(公告)号：US07776834B2
公开(公告)日：2010-08-17
申请号：US11268714
申请日：2005-11-07
申请人： Sudhir Agrawal , Dong Yu , Ekambar Kandimalla
发明人： Sudhir Agrawal , Dong Yu , Ekambar Kandimalla
IPC分类号： A61K31/70 , A61K38/00 , A61K37/18 , A61K39/00 , A61K39/35 , A61K39/36 , A01N43/04 , C07H21/02 , C07H21/04
CPC分类号： A61K31/70
摘要： The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides an immunostimulatory oligonucleotides for use in methods for generating an immune response or for treating a patient in need of immunostimulation. The immunostimulatory oligonucleotides of the invention preferably comprise novel purines. The immunostimulatory oligonucleotides according to the invention further comprise at least two oligonucleotides linked at their 3′ ends, internucleoside linkages or functionalized nucleobase or sugar to a non-nucleotidic linker, at least one of the oligonucleotides being an immunostimulatory oligonucleotide and having an accessible 5′ end.
摘要翻译： 本发明涉及在免疫治疗应用中寡核苷酸作为免疫刺激剂的治疗用途。 更具体地，本发明提供了用于产生免疫应答的方法或用于治疗需要免疫刺激的患者的免疫刺激性寡核苷酸。 本发明的免疫刺激性寡核苷酸优选包含新的嘌呤。 根据本发明的免疫刺激性寡核苷酸还包含至少两个在其3'末端连接的寡核苷酸，核苷间键或官能化核碱基或糖与非核酸连接体，至少一个寡核苷酸是免疫刺激性寡核苷酸并具有可接近的5' 结束。
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5.发明申请公开(公告)号：US20100111937A1
公开(公告)日：2010-05-06
申请号：US12612413
申请日：2009-11-04
申请人： Ekambar Kandimalla , Mallikarjuna Putta , Lakshmi Bhagat , Daqing Wang , Dong Yu , Sudhir Agrawal
发明人： Ekambar Kandimalla , Mallikarjuna Putta , Lakshmi Bhagat , Daqing Wang , Dong Yu , Sudhir Agrawal
IPC分类号： A61K48/00 , C07H21/02 , A61K39/00 , A61K39/395 , A61K39/35 , A61K38/02 , A61P29/00 , A61P31/00
CPC分类号： A61K39/39 , A61K2039/55561 , C07H21/04 , C12N15/1138 , C12N2310/11 , Y02A50/401 , Y02A50/412 , Y02A50/414
摘要： Antisense oligonucleotide compounds, compositions and methods are provided for down regulating the expression of TLR5. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding TLR5. The compositions may also comprise antisense oligonucleotides targeted to nucleic acids encoding TLR5 in combination with other therapeutic and/or prophylactic compounds and/or compositions. Methods of using these compounds and compositions for down-regulating TLR5 expression and for prevention or treatment of diseases wherein modulation of TLR5 expression would be beneficial are provided.
摘要翻译： 提供反义寡核苷酸化合物，组合物和方法用于下调TLR5的表达。 组合物包含靶向编码TLR5的核酸的反义寡核苷酸。 组合物还可以包含靶向编码TLR5的核酸与其它治疗和/或预防化合物和/或组合物组合的反义寡核苷酸。 提供这些化合物和组合物用于下调TLR5表达和预防或治疗TLR5表达调节将是有益的疾病的方法。
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6.发明申请IMMUNE REGULATORY OLIGONUCLEOTIDE (IRO) COMPOUNDS TO MODULATE TOLL-LIKE RECEPTOR BASED IMMUNE RESPONSE 有权免疫调节寡核苷酸（IRO）化合物，以调节基于类似感受器的免疫应答公开(公告)号：US20090081198A1
公开(公告)日：2009-03-26
申请号：US12140338
申请日：2008-06-17
申请人： Ekambar Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
发明人： Ekambar Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
IPC分类号： A61K39/395 , A61K31/7052 , A61K38/02 , A61P37/06 , A61K38/16 , A61K39/00
CPC分类号： A61K48/00 , A61K31/7052 , A61K2039/55561 , Y02A50/414
摘要： The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.
摘要翻译： 本发明提供作为TLR拮抗剂的新型免疫调节寡核苷酸（IRO）及其使用方法。 这些IRO具有独特的序列，其响应于TLR配体或TLR激动剂抑制或抑制TLR介导的信号传导。 该方法可用于预防和治疗癌症，自身免疫性疾病，气道炎症，炎症性疾病，感染性疾病，皮肤病，变态反应，哮喘或由病原体引起的疾病。
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公开(公告)号：US20080292648A1
公开(公告)日：2008-11-27
申请号：US11954726
申请日：2007-12-12
申请人： Ekambar Kandimalla , Mallikarjuna Putta , Dong Yu , Lakshmi Bhagat , Daqing Wang , Sudhir Agrawal
发明人： Ekambar Kandimalla , Mallikarjuna Putta , Dong Yu , Lakshmi Bhagat , Daqing Wang , Sudhir Agrawal
CPC分类号： C12N15/117 , C12N2310/17 , C12N2310/315 , C12N2310/317 , C12N2310/3183 , C12N2310/321 , C12N2310/336 , C12N2310/3521
摘要： The invention provides novel oligonucleotide-based compounds that individually provide distinct immune response profiles through their interactions as agonists with TLR9. The TLR9 agonists according to the invention are characterized by specific and unique chemical modifications, which provide their distinctive immune response activation profiles.
摘要翻译： 本发明提供了新的基于寡核苷酸的化合物，其通过作为具有TLR9的激动剂的相互作用单独提供不同的免疫应答谱。 根据本发明的TLR9激动剂的特征在于特异性和独特的化学修饰，其提供其独特的免疫应答活化谱。
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公开(公告)号：US20080193437A1
公开(公告)日：2008-08-14
申请号：US11876913
申请日：2007-10-23
申请人： Sudhir Agrawal , Ekambar Kandimalla , Dong Yu
发明人： Sudhir Agrawal , Ekambar Kandimalla , Dong Yu
IPC分类号： A61K39/35 , A61K31/711 , A61K39/395 , A61K38/02 , A61K39/00 , A61K45/00
CPC分类号： A61K31/711 , A61K38/2013 , A61K39/39 , A61K2039/55561 , A61N2005/1098 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12N2310/318 , C12N2310/334 , C12N2310/336 , C12N2310/3519 , A61K2300/00
摘要： The invention provides an immunostimulatory nucleic acid. In certain embodiments according to this aspect of the invention, the sequence of the immunostimulatory oligonucleotide and/or immunomer is at least partially self-complementary.
摘要翻译： 本发明提供免疫刺激性核酸。 在根据本发明的该方面的某些实施方案中，免疫刺激性寡核苷酸和/或免疫反应物的序列至少部分自身互补。
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公开(公告)号：US07405285B2
公开(公告)日：2008-07-29
申请号：US11234396
申请日：2005-09-22
申请人： Sudhir Agrawal , Ekambar Kandimalla , Dong Yu
发明人： Sudhir Agrawal , Ekambar Kandimalla , Dong Yu
IPC分类号： C07H21/02
CPC分类号： A61K31/711 , A61K38/2013 , A61K39/39 , A61K2039/55561 , A61N2005/1098 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12N2310/318 , C12N2310/334 , C12N2310/336 , C12N2310/3519 , A61K2300/00
摘要： The invention provides an immunostimulatory nucleic acid. In certain embodiments according to this aspect of the invention, the sequence of the immunostimulatory oligonucleotide and/or immunomer is at least partially self-complementary.
摘要翻译： 本发明提供免疫刺激性核酸。 在根据本发明的该方面的某些实施方案中，免疫刺激性寡核苷酸和/或免疫反应物的序列至少部分自身互补。
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10.发明授权公开(公告)号：US08426375B2
公开(公告)日：2013-04-23
申请号：US12140334
申请日：2008-06-17
申请人： Ekambar Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
发明人： Ekambar Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
CPC分类号： A61K48/00 , A61K31/7088 , A61K39/0008 , A61K2039/55561 , Y02A50/401
摘要： The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.
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