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公开(公告)号:US20140286925A1
公开(公告)日:2014-09-25
申请号:US14295798
申请日:2014-06-04
Applicant: Syntaxin Limited
Inventor: Frederic MADEC , Philip LECANE , Philip MARKS , Keith FOSTER
IPC: C12N9/50
CPC classification number: C12N9/50 , A61K38/4893 , A61K47/60 , A61K47/6415 , C07K14/4756 , C07K14/485 , C07K14/495 , C07K14/50 , C07K14/503 , C07K14/52 , C07K14/522 , C07K14/5412 , C07K14/65 , C07K14/705 , C07K2319/50 , C07K2319/55 , C07K2319/74 , C12N9/52
Abstract: The present invention relates to polypeptides for use in suppressing cancer and cancer disorders. The treatment employs use of a non-cytotoxic protease, which is targeted to the cancer cell, and, when so delivered, the protease is internalised and inhibits secretion from the cancer cell.
Abstract translation: 本发明涉及用于抑制癌症和癌症疾病的多肽。 该治疗使用靶向癌细胞的非细胞毒性蛋白酶,并且当这样递送时,蛋白酶被内化并且抑制癌细胞的分泌。