公开(公告)号：US20140286925A1

公开(公告)日：2014-09-25

申请号：US14295798

申请日：2014-06-04

Applicant: Syntaxin Limited

Inventor： Frederic MADEC ,  Philip LECANE ,  Philip MARKS ,  Keith FOSTER

IPC: C12N9/50

CPC classification number: C12N9/50 ,  A61K38/4893 ,  A61K47/60 ,  A61K47/6415 ,  C07K14/4756 ,  C07K14/485 ,  C07K14/495 ,  C07K14/50 ,  C07K14/503 ,  C07K14/52 ,  C07K14/522 ,  C07K14/5412 ,  C07K14/65 ,  C07K14/705 ,  C07K2319/50 ,  C07K2319/55 ,  C07K2319/74 ,  C12N9/52

Abstract: The present invention relates to polypeptides for use in suppressing cancer and cancer disorders. The treatment employs use of a non-cytotoxic protease, which is targeted to the cancer cell, and, when so delivered, the protease is internalised and inhibits secretion from the cancer cell.

Abstract translation: 本发明涉及用于抑制癌症和癌症疾病的多肽。 该治疗使用靶向癌细胞的非细胞毒性蛋白酶，并且当这样递送时，蛋白酶被内化并且抑制癌细胞的分泌。

公开(公告)号：US20140219983A1

公开(公告)日：2014-08-07

申请号：US14250954

申请日：2014-04-11

Applicant: Syntaxin Limited

Inventor： Frederic MADEC ,  Phil LECANE ,  Philip MARKS ,  Keith FOSTER

IPC: C12N9/50 ,  C07K14/60 ,  C07K14/33 ,  C07K14/82 ,  C07K7/08 ,  C07K14/48 ,  C07K14/575 ,  C07K14/65

Abstract: The present invention relates to a method for suppressing or treating cancer, in particular to a method for suppressing or treating one or more of colorectal cancer, breast cancer, prostate cancer and/or lung cancer. The therapy employs use of a non-cytotoxic protease, which is targeted to a growth hormone-secreting cell such as to a pituitary cell. When so delivered, the protease is internalised and inhibits secretion/transmission of growth hormone from said cell. The present invention also relates to polypeptides and nucleic acids for use in said methods.

Abstract translation: 本发明涉及抑制或治疗癌症的方法，特别涉及抑制或治疗结肠直肠癌，乳腺癌，前列腺癌和/或肺癌中的一种或多种的方法。 该疗法使用非细胞毒性蛋白酶，其靶向生长激素分泌细胞，例如垂体细胞。 当这样传递时，蛋白酶被内化并且抑制生长激素从所述细胞的分泌/传递。 本发明还涉及用于所述方法的多肽和核酸。