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公开(公告)号：US10159677B2
公开(公告)日：2018-12-25
申请号：US15683589
申请日：2017-08-22
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Stephen Hitchcock , Betty Lam , Holger Monenschein , Holly Reichard
IPC: C07D253/08 , A61K31/53 , A61P25/18
Abstract: The present invention provides a method for treating a disease, disorder or condition associated with GPR139 using compounds of formula 1: which are agonists of GPR139, certain compounds encompassed by formula 1, pharmaceutical compositions thereof, processes for making the compounds, and intermediates thereof.
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公开(公告)号：US10000468B2
公开(公告)日：2018-06-19
申请号：US15118461
申请日：2015-02-13
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Mark E. Adams , Jason W. Brown , Stephen Hitchcock , Maria Hopkins , Shota Kikuchi , Betty Lam , Holger Monenschein , Holly Reichard , Huikai Sun
IPC: C07D401/14 , C07D241/28 , C07D401/04
CPC classification number: C07D401/14 , A61K31/497 , A61K31/506 , A61K31/551 , C07D241/26 , C07D241/28 , C07D401/04
Abstract: The present invention provides compounds of formula I: which are useful as modulators of GPR6, pharmaceutical compositions thereof, methods for treatment of conditions associated with GPR6, processes for making the compounds and intermediates thereof.
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公开(公告)号：US09770450B2
公开(公告)日：2017-09-26
申请号：US15382490
申请日：2016-12-16
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Stephen Hitchcock , Betty Lam , Holger Monenschein , Holly Reichard
IPC: A61K31/53 , C07D253/08 , A61P25/18
CPC classification number: A61K31/53 , C07D253/08
Abstract: The present invention provides a method for treating a disease, disorder or condition associated with GPR139 using compounds of formula 1: which are agonists of GPR139, certain compounds encompassed by formula 1, pharmaceutical compositions thereof, processes for making the compounds, and intermediates thereof.
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公开(公告)号：US20150336964A1
公开(公告)日：2015-11-26
申请号：US14814878
申请日：2015-07-31
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Yasuyoshi Arikawa , Benjamin Jones , Betty Lam , Christopher Smith , Masashi Takahashi , Qing Dong , Victoria Feher , Zhe Nie
IPC: C07D487/04 , A61K45/06 , A61K31/527 , A61K31/437 , C07D487/10 , A61K31/519 , C07D471/04
CPC classification number: C07D487/04 , A61K31/437 , A61K31/519 , A61K31/527 , A61K45/06 , C07D471/04 , C07D487/10 , C07D519/00
Abstract: Disclosed are compounds of Formula 1, and pharmaceutically acceptable salts thereof, wherein G, L1, L2, R1, R2, R3, and R4 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, pharmaceutical compositions containing them, and their use for treating disorders, diseases, and conditions involving the immune system and inflammation, including rheumatoid arthritis, hematological malignancies, epithelial cancers (i.e., carcinomas), and other disorders, diseases, and conditions for which inhibition of SYK is indicated.
Abstract translation: 公开了式1的化合物及其药学上可接受的盐，其中G，L1，L2，R1，R2，R3和R4在说明书中定义。 本公开还涉及用于制备式1化合物的材料和方法，含有它们的药物组合物及其用于治疗涉及免疫系统和炎症的疾病，疾病和病症的用途，包括类风湿性关节炎，血液恶性肿瘤，上皮癌（即， 癌症）以及其它疾病，疾病和表示SYK抑制的病症。
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公开(公告)号：US11173161B2
公开(公告)日：2021-11-16
申请号：US16732536
申请日：2020-01-02
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Stephen Hitchcock , Betty Lam , Holger Monenschein , Holly Reichard
IPC: A61K31/53 , A61P25/18 , C07D253/08
Abstract: The present invention provides a method for treating a disease, disorder or condition associated with GPR139 using compounds of formula 1: which are agonists of GPR139, certain compounds encompassed by formula 1, pharmaceutical compositions thereof, processes for making the compounds, and intermediates thereof.
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Patent Agency Ranking
公开(公告)号：US10273225B2
公开(公告)日：2019-04-30
申请号：US15979069
申请日：2018-05-14
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Mark E. Adams , Jason W. Brown , Stephen Hitchcock , Maria Hopkins , Shota Kikuchi , Betty Lam , Holger Monenschein , Holly Reichard , Huikai Sun
IPC: C07D401/04 , C07D401/14 , C07D241/26 , C07D241/28 , A61K31/497 , A61K31/506 , A61K31/551
Abstract: The present invention provides compounds of formula I: which are useful as modulators of GPR6, pharmaceutical compositions thereof, methods for treatment of conditions associated with GPR6, processes for making the compounds and intermediates thereof.
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公开(公告)号：US20170095480A1
公开(公告)日：2017-04-06
申请号：US15382490
申请日：2016-12-16
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Stephen Hitchcock , Betty Lam , Holger Monenschein , Holly Reichard
IPC: A61K31/53
CPC classification number: A61K31/53 , C07D253/08
Abstract: The present invention provides a method for treating a disease, disorder or condition associated with GPR139 using compounds of formula 1: which are agonists of GPR139, certain compounds encompassed by formula 1, pharmaceutical compositions thereof, processes for making the compounds, and intermediates thereof.
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公开(公告)号：US10561662B2
公开(公告)日：2020-02-18
申请号：US16179709
申请日：2018-11-02
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Stephen Hitchcock , Betty Lam , Holger Monenschein , Holly Reichard
IPC: C07D253/08 , A61K31/53 , A61P25/18
Abstract: The present invention provides a method for treating a disease, disorder or condition associated with GPR139 using compounds of formula 1: which are agonists of GPR139, certain compounds encompassed by formula 1, pharmaceutical compositions thereof, processes for making the compounds, and intermediates thereof.
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公开(公告)号：US20190070187A1
公开(公告)日：2019-03-07
申请号：US16179709
申请日：2018-11-02
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Stephen Hitchcock , Betty Lam , Holger Monenschein , Holly Reichard
IPC: A61K31/53 , C07D253/08
Abstract: The present invention provides a method for treating a disease, disorder or condition associated with GPR139 using compounds of formula 1: which are agonists of GPR139, certain compounds encompassed by formula 1, pharmaceutical compositions thereof, processes for making the compounds, and intermediates thereof.
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公开(公告)号：US20180258073A1
公开(公告)日：2018-09-13
申请号：US15979069
申请日：2018-05-14
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Mark E. Adams , Jason W. Brown , Stephen Hitchcock , Maria Hopkins , Shota Kikuchi , Betty Lam , Holger Monenschein , Holly Reichard , Huikai Sun
IPC: A61K31/551 , C07D401/04 , C07D401/14 , C07D241/28
CPC classification number: C07D401/14 , A61K31/497 , A61K31/506 , A61K31/551 , C07D241/26 , C07D241/28 , C07D401/04
Abstract: The present invention provides compounds of formula I: which are useful as modulators of GPR6, pharmaceutical compositions thereof, methods for treatment of conditions associated with GPR6, processes for making the compounds and intermediates thereof.
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