公开(公告)号：US11802107B2

公开(公告)日：2023-10-31

申请号：US18075399

申请日：2022-12-05

Applicant: Signum Biosciences, Inc.

Inventor： Michael Voronkov ,  Eduardo Perez ,  Jason Healy ,  Jose Fernandez

IPC: C07C275/20 ,  A61P29/00 ,  A61K9/00 ,  C07C233/47 ,  C07D205/04 ,  C07D207/16 ,  C07D213/80 ,  C07D221/00 ,  C07D239/42 ,  C07D241/28 ,  C07C233/04

CPC classification number: C07C275/20 ,  A61K9/0014 ,  A61P29/00 ,  C07C233/04 ,  C07D205/04 ,  C07D207/16 ,  C07D213/80 ,  C07D221/00 ,  C07D239/42 ,  C07D241/28

Abstract: The present invention provides compounds useful in treating or preventing inflammation, acne, bacterial conditions and promoting the appearance of healthy skin and compositions including these compounds.

公开(公告)号：US20220281830A1

公开(公告)日：2022-09-08

申请号：US17635710

申请日：2020-08-19

Applicant: NIPPON SHINYAKU CO., LTD.

Inventor： Yasushi KOKUBO ,  Toshitaka YAMAMOTO ,  Koji NAKAMICHI ,  Domenico CROCCO

IPC: C07D241/20 ,  C07D241/28

Abstract: The present invention relates to a novel salt of 2-(4-(5,6-diphenylpyrazin-2-yl)(isopropyl)amino)butoxy)acetic acid (hereinafter referred to as “Compound B”) and a crystal of the salt thereof.

公开(公告)号：US20220002254A9

公开(公告)日：2022-01-06

申请号：US17066702

申请日：2020-10-09

Applicant: MediBeacon Inc.

Inventor： Thomas E. Rogers

IPC: C07D241/28

Abstract: A process for preparing pyrimido[4,5-g]pteridine-2,4,7,9-tetraol, or a salt thereof, is provided. A process for the preparation of 3,6-diaminopyrazine-2,5-dicarboxylic acid, or a salt thereof, from pyrimido[4,5-g]pteridine-2,4,7,9-tetraol, or a salt thereof, is further provided. A process for preparing a substituted pteridine compound, or a salt thereof, is further provided. A process for the preparation of a N-substituted 3,6-diaminopyrazine-2,5-dicarboxylic acid from a substituted pteridine compound, or a salt thereof, is further provided.

公开(公告)号：US10464920B2

公开(公告)日：2019-11-05

申请号：US15742276

申请日：2016-07-06

Applicant: UNIVERSITE AMIENS PICARDIE JULES VERNE ,  CENTRE HOSPITALIER UNIVERSITAIRE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS- ,  INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)

Inventor： Nobumichi André Sasaki ,  Pascal Sonnet ,  Agnès Boullier ,  Elodie Lohou

IPC: C07D401/06 ,  C07C233/09 ,  C07C233/65 ,  C07D213/63 ,  C07C235/34 ,  C07C235/56 ,  C07D241/28 ,  C07D295/185 ,  C07D295/192 ,  C07D213/69 ,  A61P9/10 ,  A61P25/16 ,  A61P25/28

Abstract: The invention relates to compounds of Formula I: or the salts thereof, as well as the use thereof in the pharmaceutical, cosmetic or agrofood industry.

公开(公告)号：US20190276435A1

公开(公告)日：2019-09-12

申请号：US16295705

申请日：2019-03-07

Applicant: Incyte Corporation

Inventor： Stacey Shepard ,  Andrew P. Combs ,  Nikoo Falahatpisheh ,  Lixin Shao

IPC: C07D403/04 ,  C07D403/14 ,  C07D403/08 ,  C07D413/04 ,  C07D417/04 ,  C07D405/12 ,  C07D241/28 ,  C07D241/20 ,  C07B59/00 ,  A61P35/00 ,  A61P9/00 ,  A61P25/28 ,  A61P37/02

Abstract: This application relates to compounds of Formula (I): or pharmaceutically acceptable salts thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：US10370362B2

公开(公告)日：2019-08-06

申请号：US14962242

申请日：2015-12-08

Applicant: MediBeacon Inc.

Inventor： William L. Neumann ,  Raghavan Rajagopalan ,  Richard B. Dorshow

IPC: A61B10/00 ,  A61B5/00 ,  A61B8/00 ,  C07D405/04 ,  C07D241/20 ,  C07D241/24 ,  C07D241/28 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D409/04 ,  C07D409/06 ,  C07D409/10 ,  C07D409/14 ,  C07D413/04 ,  C07D417/04 ,  C07D473/18 ,  C07D473/34 ,  A61K49/00 ,  C07D241/12 ,  C07D241/26

Abstract: The present invention relates to pyrazine derivatives capable of absorbing and emanating spectral energy in the visible and/or near infrared spectrum. Pyrazine derivatives of the invention may be administered to a patient in the form of a pharmaceutically acceptable composition and utilized in medical (e.g., diagnostic imaging) procedures.

公开(公告)号：US10071970B2

公开(公告)日：2018-09-11

申请号：US15452387

申请日：2017-03-07

Applicant: Parion Sciences, Inc.

Inventor： Michael R. Johnson

IPC: C07D241/28 ,  A61K31/047 ,  A61K31/4965 ,  A61K33/14 ,  A61K45/06 ,  C07D241/26

CPC classification number: C07D241/28 ,  A61K31/047 ,  A61K31/4965 ,  A61K33/14 ,  A61K45/06 ,  C07D241/26

Abstract: This invention provides compounds of the formula I: and their pharmaceutically acceptable salts, useful as sodium channel blockers, compositions containing the same, therapeutic methods and uses for the same and processes for preparing the same.

公开(公告)号：US10005741B2

公开(公告)日：2018-06-26

申请号：US15873704

申请日：2018-01-17

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Carl Wagner ,  Pamela Marshall ,  Peter Jurutka

IPC: C07D249/18 ,  C07D209/08 ,  C07D213/48 ,  C07D213/74 ,  C07D213/79 ,  C07D215/227 ,  C07D235/10 ,  C07D239/42 ,  C07D241/20 ,  C07D241/28 ,  C07D307/79 ,  C07D333/54 ,  C07C57/50 ,  C07D223/06 ,  C07C309/31 ,  C07C223/06 ,  A61K31/505

CPC classification number: C07D249/18 ,  A61K31/505 ,  A61P3/00 ,  A61P25/00 ,  A61P35/00 ,  C07C57/50 ,  C07C223/06 ,  C07C309/31 ,  C07C2602/10 ,  C07D209/08 ,  C07D213/48 ,  C07D213/74 ,  C07D213/79 ,  C07D215/227 ,  C07D235/10 ,  C07D239/42 ,  C07D241/20 ,  C07D241/28 ,  C07D307/79 ,  C07D333/54

Abstract: The invention provides compounds and compositions that are useful for treating conditions including Alzheimer's disease, Parkinson's disease, diabetes, cancer, and psychotic disorders such as schizophrenia.

公开(公告)号：US10000468B2

公开(公告)日：2018-06-19

申请号：US15118461

申请日：2015-02-13

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Mark E. Adams ,  Jason W. Brown ,  Stephen Hitchcock ,  Maria Hopkins ,  Shota Kikuchi ,  Betty Lam ,  Holger Monenschein ,  Holly Reichard ,  Huikai Sun

IPC: C07D401/14 ,  C07D241/28 ,  C07D401/04

CPC classification number: C07D401/14 ,  A61K31/497 ,  A61K31/506 ,  A61K31/551 ,  C07D241/26 ,  C07D241/28 ,  C07D401/04

Abstract: The present invention provides compounds of formula I: which are useful as modulators of GPR6, pharmaceutical compositions thereof, methods for treatment of conditions associated with GPR6, processes for making the compounds and intermediates thereof.

公开(公告)号：USRE46757E1

公开(公告)日：2018-03-20

申请号：US14755691

申请日：2015-06-30

Applicant: Novartis AG

Inventor： Urs Baettig ,  Kamlesh Jagdis Bala ,  Emma Budd ,  Lee Edwards ,  Catherine Howsham ,  Glyn Alan Hughes ,  Darren Mark Legrand ,  Katrin Spiegel

IPC: A61K31/5355 ,  C07D213/26 ,  A61K31/4965 ,  A61K31/4453 ,  C07D241/16 ,  C07D213/04 ,  C07D213/61 ,  C07D413/12 ,  C07D211/06 ,  A61K31/497 ,  C07D213/22 ,  A61K31/445 ,  A61K31/444 ,  A61K31/443 ,  A61K31/454 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/4418 ,  A61K31/4545 ,  A61K31/4412 ,  A61K31/5377 ,  A61K45/06 ,  C07D213/81 ,  C07D241/28 ,  C07D241/26 ,  C07D213/38 ,  C07D401/12 ,  C07D401/04 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07D413/04

CPC classification number: A61K31/44 ,  A61K31/4412 ,  A61K31/4418 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4965 ,  A61K31/497 ,  A61K31/5377 ,  A61K45/06 ,  C07D213/38 ,  C07D213/81 ,  C07D241/26 ,  C07D241/28 ,  C07D401/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07D413/04 ,  C07D413/12

Abstract: The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.