公开(公告)号：US20200339573A1

公开(公告)日：2020-10-29

申请号：US16870653

申请日：2020-05-08

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Rongliang Chen ,  Tomonori Ichibakase ,  Chunrong Ma ,  Christopher F. Matthews ,  Hajime Motoyoshi ,  Colin O'Bryan ,  Kentaro Yaji ,  Naoki Yoshikawa

IPC: C07D471/04 ,  A61K9/20 ,  A61K9/48

Abstract: Disclosed are chemical entities which are inhibitors of spleen tyrosine kinase (SYK), namely, chemical entities comprising 6-((1R,2S)-2-aminocyclohexylamino)-7-fluoro-4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,4-c]pyridine-3(2H)-one and certain solid state forms thereof. Also disclosed are methods of using the chemical entities to treat disorders such as a cancer.

公开(公告)号：US10676473B2

公开(公告)日：2020-06-09

申请号：US14973180

申请日：2015-12-17

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Rongliang Chen ,  Tomonori Ichibakase ,  Chunrong Ma ,  Christopher F. Matthews ,  Hajime Motoyoshi ,  Colin O'Bryan ,  Kentaro Yaji ,  Naoki Yoshikawa

IPC: C07D471/04 ,  A61K9/20 ,  A61K9/48

Abstract: Disclosed are chemical entities which are inhibitors of spleen tyrosine kinase (SYK), namely, chemical entities comprising 6-((1R,2S)-2-aminocyclohexylamino)-7-fluoro-4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,4-c]pyridine-3(2H)-one and certain solid state forms thereof. Also disclosed are methods of using the chemical entities to treat disorders such as a cancer.