公开(公告)号：US20170174682A1

公开(公告)日：2017-06-22

申请号：US15452003

申请日：2017-03-07

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Masato YOSHIDA ,  Hiroyuki NAGAMIYA ,  Yusuke OHBA ,  Masaki SETO ,  Takatoshi YOGO ,  Satoshi SASAKI ,  Norihito TOKUNAGA ,  Kazuyoshi ASO

IPC: C07D471/04 ,  C07D519/00

CPC classification number: C07D471/04 ,  C07D519/00

Abstract: Provided is a compound or a salt thereof, which has an excellent JAK inhibitory action, and is useful as a prophylactic or therapeutic agent for autoimmune diseases (rheumatoid arthritis, psoriasis, inflammatory bowel disease, Sjogren's syndrome, Behcet's syndrome, multiple sclerosis, systemic lupus erythematosus, etc.), cancer (leukemia, uterine leiomyosarcoma, prostate cancer, multiple myeloma, cachexia, myelofibrosis, etc.) and the like. The present invention relates to a compound represented by the formula (I) wherein each symbol is as defined in the present specification, or a salt thereof.

公开(公告)号：US20150238506A1

公开(公告)日：2015-08-27

申请号：US14708433

申请日：2015-05-11

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Junya SHIRAI ,  Tomokazu KUSUMOTO ,  Hiroyuki NAGAMIYA ,  Izumi KAMO

IPC: A61K31/553 ,  A61K31/4353

CPC classification number: A61K31/553 ,  A61B5/04882 ,  A61B5/202 ,  A61B5/205 ,  A61K31/00 ,  A61K31/4353 ,  A61N1/36007 ,  C07D223/16 ,  C07D487/04 ,  C07D498/04 ,  C07D519/00 ,  G01N33/942

Abstract: The present invention relates to a serotonin 5-HT2C receptor activator containing a compound represented by the formula wherein ring A is a 5- or 6-membered aromatic heterocycle optionally having substituent(s), and ring B is a 7- to 9-membered ring optionally having substituent(s) other than an oxo group wherein the combination of m and n (m,n) is (1,2), (2,1), (2,2), (3,1), (3,2) or (4,1), or a salt thereof or a prodrug thereof, and a fused heterocyclic compound having a serotonin 5-HT2C receptor activating action and the like.

Abstract translation: 本发明涉及含有下式表示的化合物的5-羟色胺5-HT 2C受体活化剂，其中环A是任选具有取代基的5-或6-元芳族杂环，环B为7-至9-元 其中m和n（m，n）的组合是（1,2），（2,1），（2,2），（3,1），（ 3,2）或（4,1）或其盐或其前药，以及具有5-羟色胺5-HT 2C受体激活作用的稠合杂环化合物等。