公开(公告)号：US20170174682A1

公开(公告)日：2017-06-22

申请号：US15452003

申请日：2017-03-07

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Masato YOSHIDA ,  Hiroyuki NAGAMIYA ,  Yusuke OHBA ,  Masaki SETO ,  Takatoshi YOGO ,  Satoshi SASAKI ,  Norihito TOKUNAGA ,  Kazuyoshi ASO

IPC: C07D471/04 ,  C07D519/00

CPC classification number: C07D471/04 ,  C07D519/00

Abstract: Provided is a compound or a salt thereof, which has an excellent JAK inhibitory action, and is useful as a prophylactic or therapeutic agent for autoimmune diseases (rheumatoid arthritis, psoriasis, inflammatory bowel disease, Sjogren's syndrome, Behcet's syndrome, multiple sclerosis, systemic lupus erythematosus, etc.), cancer (leukemia, uterine leiomyosarcoma, prostate cancer, multiple myeloma, cachexia, myelofibrosis, etc.) and the like. The present invention relates to a compound represented by the formula (I) wherein each symbol is as defined in the present specification, or a salt thereof.

公开(公告)号：US20150299188A1

公开(公告)日：2015-10-22

申请号：US14423310

申请日：2013-08-23

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Masaki OGINO ,  Zenichi IKEDA ,  Jun FUJIMOTO ,  Yusuke OHBA ,  Naoki ISHII ,  Takuya FUJIMOTO ,  Tsuneo ODA ,  Naohiro TAYA ,  Toshiro YAMASHITA ,  Nobuyuki MATSUNAGA

IPC: C07D471/04

CPC classification number: C07D471/04 ,  A61K9/2018 ,  A61K9/4858 ,  C07D239/80 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/04 ,  C07D417/12 ,  C07D487/04 ,  C07D513/04 ,  C07D519/00

Abstract: Provided is a compound having a superior FLAP inhibitory action and useful as a prophylactic or therapeutic agent for arteriosclerosis and the like, and a salt thereof. The present invention relates to a compound represented by the formula wherein each symbol is as defined in the present DESCRIPTION, or a salt thereof.

Abstract translation: 提供具有优异的FLAP抑制作用并可用作动脉硬化等的预防或治疗剂及其盐的化合物。 本发明涉及由下式表示的化合物，其中各符号如本说明书所定义，或其盐。