公开(公告)号：US20210115039A1

公开(公告)日：2021-04-22

申请号：US17131024

申请日：2020-12-22

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Kentaro IWATA ,  Yukihiro IKEDA

IPC: C07D471/04

Abstract: Improving the solubility of an organic compound. A cocrystal of (1) 6-ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-3-(2,2,2-trifluoroethoxy)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide and (2) L-malic acid or L-tartaric acid.

公开(公告)号：US20250026751A1

公开(公告)日：2025-01-23

申请号：US18598351

申请日：2024-03-07

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Kentaro IWATA ,  Yukihiro IKEDA

IPC: C07D471/04

Abstract: Improving the solubility of an organic compound. A cocrystal of (1) 6-ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-3-(2,2,2-trifluoroethoxy)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide and (2) L-malic acid or L-tartaric acid.

公开(公告)号：US20230102273A1

公开(公告)日：2023-03-30

申请号：US16088096

申请日：2017-03-27

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Kentaro IWATA ,  Masahiro MIZUNO ,  Kazuhiro MAEDA ,  Tsuneo YASUMA ,  Misaki HOMMA ,  Yuya OGURO ,  Naohiro TAYA ,  Lei ZHU ,  John Daniel BAILEY ,  Marianne LANGSTON ,  Siddhesh Dinanath PATIL ,  Shruti GOUR ,  Lilly ROY

IPC: C07D471/08 ,  A61K9/48

Abstract: The present disclosure relates to crystalline forms of 2-[(2S)-1-azabicyclo[2.2.2]oct-2-yl]-6-(3-methyl-1H-pyrazol-4-yl)thieno[3,2-d]pyrimidin-4(3H)-one hemihydrate (Compound 1) and/or tautomers thereof, wherein Compound 1 has the structure: (I).0.5H2O; processes for preparing crystalline forms of Compound 1 and/or tautomers thereof; pharmaceutical compositions comprising the crystalline forms; methods of inhibiting a cell division cycle 7 in a mammal comprising administering the crystalline forms; and methods of treating a cell division cycle 7 mediated cancer in a mammal comprising administering the crystalline forms or a pharmaceutical composition comprising the crystalline forms.

公开(公告)号：US20200048245A1

公开(公告)日：2020-02-13

申请号：US16074339

申请日：2017-01-31

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Kentaro IWATA ,  Yukihiro IKEDA

IPC: C07D471/04

Abstract: Improving the solubility of an organic compound. A cocrystal of (1) 6-ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-3-(2,2,2-trifluoroethoxy)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide and (2) L-malic acid or L-tartaric acid.