公开(公告)号：US20230102273A1

公开(公告)日：2023-03-30

申请号：US16088096

申请日：2017-03-27

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Kentaro IWATA ,  Masahiro MIZUNO ,  Kazuhiro MAEDA ,  Tsuneo YASUMA ,  Misaki HOMMA ,  Yuya OGURO ,  Naohiro TAYA ,  Lei ZHU ,  John Daniel BAILEY ,  Marianne LANGSTON ,  Siddhesh Dinanath PATIL ,  Shruti GOUR ,  Lilly ROY

IPC: C07D471/08 ,  A61K9/48

Abstract: The present disclosure relates to crystalline forms of 2-[(2S)-1-azabicyclo[2.2.2]oct-2-yl]-6-(3-methyl-1H-pyrazol-4-yl)thieno[3,2-d]pyrimidin-4(3H)-one hemihydrate (Compound 1) and/or tautomers thereof, wherein Compound 1 has the structure: (I).0.5H2O; processes for preparing crystalline forms of Compound 1 and/or tautomers thereof; pharmaceutical compositions comprising the crystalline forms; methods of inhibiting a cell division cycle 7 in a mammal comprising administering the crystalline forms; and methods of treating a cell division cycle 7 mediated cancer in a mammal comprising administering the crystalline forms or a pharmaceutical composition comprising the crystalline forms.

公开(公告)号：US20230192685A1

公开(公告)日：2023-06-22

申请号：US17927584

申请日：2021-05-26

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Hitoaki NISHIKAWA ,  Naohiro TAYA ,  Hiroshi BANNO ,  Masatoshi YAMADA ,  Kazuki AZUMA ,  Ayaka SUZUKI

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: A method for producing a compound represented by the formula (X):




or a salt thereof and has a MALT1 inhibitory action, the said method containing a step for producing a compound a compound represented by the formula (B-2):




or a salt thereof and being characterized by comprising crystallizing a salt of a compound represented by the formula (B-1)




and an optically active organic acid.

(In the formulae, each symbol is as defined in the specification.)

公开(公告)号：US20150299188A1

公开(公告)日：2015-10-22

申请号：US14423310

申请日：2013-08-23

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Masaki OGINO ,  Zenichi IKEDA ,  Jun FUJIMOTO ,  Yusuke OHBA ,  Naoki ISHII ,  Takuya FUJIMOTO ,  Tsuneo ODA ,  Naohiro TAYA ,  Toshiro YAMASHITA ,  Nobuyuki MATSUNAGA

IPC: C07D471/04

CPC classification number: C07D471/04 ,  A61K9/2018 ,  A61K9/4858 ,  C07D239/80 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/04 ,  C07D417/12 ,  C07D487/04 ,  C07D513/04 ,  C07D519/00

Abstract: Provided is a compound having a superior FLAP inhibitory action and useful as a prophylactic or therapeutic agent for arteriosclerosis and the like, and a salt thereof. The present invention relates to a compound represented by the formula wherein each symbol is as defined in the present DESCRIPTION, or a salt thereof.

Abstract translation: 提供具有优异的FLAP抑制作用并可用作动脉硬化等的预防或治疗剂及其盐的化合物。 本发明涉及由下式表示的化合物，其中各符号如本说明书所定义，或其盐。

公开(公告)号：US20160046601A1

公开(公告)日：2016-02-18

申请号：US14925259

申请日：2015-10-28

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Takanobu KUROITA ,  Yasuhiro IMAEDA ,  Kouichi IWANAGA ,  Naohiro TAYA ,  Hidekazu TOKUHARA ,  Yoshiyuki FUKASE

IPC: C07D401/12 ,  C07D495/04 ,  C07D413/14 ,  C07D401/14 ,  C07D453/02 ,  C07D471/04 ,  C07D405/14

CPC classification number: C07D401/12 ,  C07D233/90 ,  C07D401/14 ,  C07D405/14 ,  C07D407/12 ,  C07D409/06 ,  C07D409/14 ,  C07D413/06 ,  C07D413/14 ,  C07D417/06 ,  C07D417/12 ,  C07D453/02 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  C07D495/04

Abstract: Compounds represented by the formulas wherein each symbol is as defined in the specification, and a prodrug thereof have a superior renin inhibitory activity, and are useful as agents for the prophylaxis or treatment of hypertension, various organ damages attributable to hypertension and the like.

公开(公告)号：US20150191486A1

公开(公告)日：2015-07-09

申请号：US14665237

申请日：2015-03-23

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Takanobu KUROITA ,  Yasuhiro IMAEDA ,  Kouichi IWANAGA ,  Naohiro TAYA ,  Hidekazu TOKUHARA ,  YOSHIYUKI FUKASE

IPC: C07D495/04 ,  C07D487/08 ,  C07D405/14 ,  C07D401/12 ,  C07D471/04

CPC classification number: C07D401/12 ,  C07D233/90 ,  C07D401/14 ,  C07D405/14 ,  C07D407/12 ,  C07D409/06 ,  C07D409/14 ,  C07D413/06 ,  C07D413/14 ,  C07D417/06 ,  C07D417/12 ,  C07D453/02 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  C07D495/04

Abstract: Compounds represented by the formulas wherein each symbol is as defined in the specification, and a prodrug thereof have a superior renin inhibitory activity, and are useful as agents for the prophylaxis or treatment of hypertension, various organ damages attributable to hypertension and the like.

Abstract translation: 由式表示的化合物，其中各符号如说明书中所定义，其前药具有优异的肾素抑制活性，可用作预防或治疗高血压，高血压等各种器官损害的药剂。