公开(公告)号：US20140171655A1

公开(公告)日：2014-06-19

申请号：US14183827

申请日：2014-02-19

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Mitsuhisa YAMANO ,  Mitsutaka GOTO ,  Shinji KAWAGUCHI ,  Masatoshi YAMADA ,  Jun-ichi KAWAKAMI

IPC: C07F9/50 ,  C07F9/572

CPC classification number: C07F9/572 ,  B01J31/2452 ,  B01J2531/80 ,  C07B53/00 ,  C07F9/5022 ,  C07F9/5027 ,  C07F15/004 ,  C07F15/0053 ,  C07F15/0066 ,  C07F15/008

Abstract: The present invention provides a novel ligand represented by the following formula and a novel transition metal complex having the ligand, which shows superior enantioselectivity and catalytic efficiency, particularly high catalyst activity, in various asymmetric synthesis reactions.A transition metal complex having, as a ligand, a compound represented by the formula wherein R4 is a hydrogen atom or a C1-6 alkyl group optionally having substituent(s), and R5 and R6 are each a C1-6 alkyl group optionally having substituent(s), or the formula is a group represented by the formula wherein ring B is a 3- to 8-membered ring optionally having substituent(s).

Abstract translation: 本发明提供了由下式表示的新型配位体和具有配位体的新型过渡金属络合物，其在各种不对称合成反应中表现出优异的对映体选择性和催化效率，特别高的催化剂活性。 一种具有下式表示的化合物作为配体的过渡金属配合物，其中R 4为氢原子或任选具有取代基的C 1-6烷基，R 5和R 6各自为任选具有 取代基，或式为由下式表示的基团：其中环B为任选具有取代基的3-至8-元环。

公开(公告)号：US20230192685A1

公开(公告)日：2023-06-22

申请号：US17927584

申请日：2021-05-26

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Hitoaki NISHIKAWA ,  Naohiro TAYA ,  Hiroshi BANNO ,  Masatoshi YAMADA ,  Kazuki AZUMA ,  Ayaka SUZUKI

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: A method for producing a compound represented by the formula (X):




or a salt thereof and has a MALT1 inhibitory action, the said method containing a step for producing a compound a compound represented by the formula (B-2):




or a salt thereof and being characterized by comprising crystallizing a salt of a compound represented by the formula (B-1)




and an optically active organic acid.

(In the formulae, each symbol is as defined in the specification.)