公开(公告)号：US20240216426A1

公开(公告)日：2024-07-04

申请号：US18557559

申请日：2022-04-27

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Nandhu SOBHANA ,  Alisha BOTHUN ,  Gil BENEZER ,  Shruti BADKAR ,  Rabi MISHRA ,  Hui-Hsin CHANG ,  Wanwen LI ,  Mansi SONI ,  Lan CAO ,  Xi SHl ,  Jane YEH ,  Mengyao LUO ,  Manoj GUPTA ,  Akito NAKAMURA ,  Doanh MAI ,  Mei Rosa NG

IPC: A61K35/15 ,  A61K39/00 ,  C07K14/54 ,  C07K14/705

CPC classification number: A61K35/15 ,  A61K39/463 ,  C07K14/54 ,  C07K14/5443 ,  C07K14/70575 ,  C07K2319/03 ,  C07K2319/30 ,  C12N2501/2315 ,  C12N2501/2321 ,  C12N2506/45 ,  C12N2510/00

Abstract: The present disclosure provides recombinant antigen presenting cells and methods of use thereof in the culture and expansion of immune cells ex vivo. In some aspects, immune cells expanded through co-culture of the recombinant antigen presenting cells disclosed herein are administered to a subject to treat a disease or condition in the subject, e.g., to treat a cancer.

公开(公告)号：US20240033359A1

公开(公告)日：2024-02-01

申请号：US18256578

申请日：2021-12-09

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED ,  CRESCENDO BIOLOGICS LTD

Inventor： Gary SHAPIRO ,  Xingyue HE ,  Mei Rosa NG ,  Lorraine THOMPSON ,  Elena DE JUAN FRANCO ,  Steven VANCE

IPC: A61K39/00 ,  C12N5/0783 ,  C12N15/86 ,  C07K16/40 ,  C07K14/725 ,  A61P35/00

CPC classification number: A61K39/464454 ,  C12N5/0636 ,  C12N15/86 ,  C07K16/40 ,  A61K39/4611 ,  A61K39/4631 ,  C07K14/7051 ,  A61P35/00 ,  C12N2740/10043 ,  C12N2501/2302 ,  C07K2317/569 ,  C07K2317/92 ,  C07K2319/03

Abstract: Antigen binding agents (e.g., single domain antibodies) that bind guanylyl cyclase C (GCC) are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions comprising these antigen binding agents and fragments thereof are also disclosed. The invention also provides therapeutic methods for utilizing the antibodies and antigen-binding molecules provided herein.

公开(公告)号：US20240050473A1

公开(公告)日：2024-02-15

申请号：US18256565

申请日：2021-12-09

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Gary SHAPIRO ,  Johara CHOUITAR ,  Xingyue HE ,  Mei Rosa NG

IPC: A61K35/17 ,  C07K16/40 ,  A61K39/00 ,  A61P35/00

CPC classification number: A61K35/17 ,  C07K16/40 ,  A61K39/4611 ,  A61K39/4631 ,  A61K39/464454 ,  A61P35/00 ,  C12Y406/01002 ,  A61K2239/13 ,  A61K2239/21 ,  A61K2239/22 ,  A61K2239/17

Abstract: Antigen binding agents (e.g., single domain antibodies) that bind guanylyl cyclase C (GCC) and chimeric antigen receptors comprising GCC antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions comprising these antigen binding agents and fragments thereof are also disclosed. The invention also provides therapeutic methods for utilizing the antibodies and antigen-binding molecules are provided herein.