公开(公告)号：US20240216426A1

公开(公告)日：2024-07-04

申请号：US18557559

申请日：2022-04-27

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Nandhu SOBHANA ,  Alisha BOTHUN ,  Gil BENEZER ,  Shruti BADKAR ,  Rabi MISHRA ,  Hui-Hsin CHANG ,  Wanwen LI ,  Mansi SONI ,  Lan CAO ,  Xi SHl ,  Jane YEH ,  Mengyao LUO ,  Manoj GUPTA ,  Akito NAKAMURA ,  Doanh MAI ,  Mei Rosa NG

IPC: A61K35/15 ,  A61K39/00 ,  C07K14/54 ,  C07K14/705

CPC classification number: A61K35/15 ,  A61K39/463 ,  C07K14/54 ,  C07K14/5443 ,  C07K14/70575 ,  C07K2319/03 ,  C07K2319/30 ,  C12N2501/2315 ,  C12N2501/2321 ,  C12N2506/45 ,  C12N2510/00

Abstract: The present disclosure provides recombinant antigen presenting cells and methods of use thereof in the culture and expansion of immune cells ex vivo. In some aspects, immune cells expanded through co-culture of the recombinant antigen presenting cells disclosed herein are administered to a subject to treat a disease or condition in the subject, e.g., to treat a cancer.

公开(公告)号：US20250031688A1

公开(公告)日：2025-01-30

申请号：US18361790

申请日：2023-07-28

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Shuxia ZHOU ,  Yana WANG ,  Lan CAO ,  Dayong GAO ,  Qiong XUE ,  Jiusong SUN ,  Huang ZHU

IPC: A01N1/02 ,  A61K39/00 ,  C07K14/54 ,  C07K14/705 ,  C07K14/725 ,  C07K16/28

Abstract: The present disclosure provides, among other things, a cryopreservation medium comprising a cryoprotectant, an albumin, a disaccharide and a non-pyrogenic and isotonic crystalloid solution. The disclosure also provides, among other things, a cryopreservation medium for cryopreserving immune cells, the medium comprising: human serum albumin (HSA), sodium chloride, sodium gluconate, sodium acetate trihydrate, potassium chloride, magnesium chloride, dimethyl sulfoxide (DMSO), and a trehalose. The present disclosure also provides, a method of cryopreserving immune cells, transporting and subsequently administering such immune cells to a patient in need thereof.

公开(公告)号：US20240306632A1

公开(公告)日：2024-09-19

申请号：US18274988

申请日：2022-02-09

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Shuxia ZHOU ,  Yana WANG ,  Lan CAO ,  Dayong GAO ,  Qiong XUE ,  Jiusong SUN ,  Huang ZHU

IPC: A01N1/02

CPC classification number: A01N1/0221 ,  A01N1/0226

Abstract: The present disclosure provides, among other things, a cryopreservation medium comprising a cryoprotectant, an albumin, a disaccharide and a non-pyrogenic and isotonic crystalloid solution. The disclosure also provides, among other things, a cryopreservation medium for cryopreserving immune cells, the medium comprising: human serum albumin (HSA), sodium chloride, sodium gluconate, sodium acetate trihydrate, potassium chloride, magnesium chloride, dimethyl sulfoxide (DMSO), and a trehalose. The present disclosure also provides, a method of cryopreserving immune cells, transporting and subsequently administering such immune cells to a patient in need thereof.