公开(公告)号：US20200148637A1

公开(公告)日：2020-05-14

申请号：US16739707

申请日：2020-01-10

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： TAKASHI OUCHI ,  GIHO GOH ,  SUNMI KIM ,  JINSOON CHOI ,  HUNSOO PARK

IPC: C07D207/36 ,  B01J23/44 ,  C07B61/00 ,  C07C253/30 ,  C07C255/42 ,  C07D401/12 ,  C07D207/34 ,  B01J8/02 ,  B01J21/04 ,  B01J29/08 ,  C07B31/00 ,  C07B41/06 ,  C07C255/28

Abstract: The present invention provides a production method of a 3-cyanopyrrole compound possibly useful as an intermediate for pharmaceutical products. A production method of compound (II) including subjecting compound (I) to a reduction reaction, in which the aforementioned reduction reaction is continuous hydrogenation reaction in a fixed bed reactor filled with a supported metal catalyst. A production method of compound (III) including subjecting compound (I) to a reduction reaction followed by a cyclization reaction, in which the aforementioned reduction reaction is continuous hydrogenation reaction in a fixed bed reactor filled with a supported metal catalyst.