公开(公告)号：US20240216426A1

公开(公告)日：2024-07-04

申请号：US18557559

申请日：2022-04-27

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Nandhu SOBHANA ,  Alisha BOTHUN ,  Gil BENEZER ,  Shruti BADKAR ,  Rabi MISHRA ,  Hui-Hsin CHANG ,  Wanwen LI ,  Mansi SONI ,  Lan CAO ,  Xi SHl ,  Jane YEH ,  Mengyao LUO ,  Manoj GUPTA ,  Akito NAKAMURA ,  Doanh MAI ,  Mei Rosa NG

IPC: A61K35/15 ,  A61K39/00 ,  C07K14/54 ,  C07K14/705

CPC classification number: A61K35/15 ,  A61K39/463 ,  C07K14/54 ,  C07K14/5443 ,  C07K14/70575 ,  C07K2319/03 ,  C07K2319/30 ,  C12N2501/2315 ,  C12N2501/2321 ,  C12N2506/45 ,  C12N2510/00

Abstract: The present disclosure provides recombinant antigen presenting cells and methods of use thereof in the culture and expansion of immune cells ex vivo. In some aspects, immune cells expanded through co-culture of the recombinant antigen presenting cells disclosed herein are administered to a subject to treat a disease or condition in the subject, e.g., to treat a cancer.