Patent search ap:("THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM") AND inv:"Sumin Gu" Page 1

1.

发明申请
CONNEXIN (CX) 43 HEMICHANNEL-BINDING ANTIBODIES AND USES THEREOF 有权

公开(公告)号：US20210253680A1

公开(公告)日：2021-08-19

申请号：US17146187

申请日：2021-01-11

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Jean X. Jiang , Zhiqiang An , Ningyan Zhang , Wei Xiong , Manuel A. Riquelme , Sumin Gu , Naomi Ledene Sayre

IPC: C07K16/18 , A61P25/28 , A61K39/395 , A61P35/00 , A61P19/10

Abstract: Antibodies that bind to connexin 43 hemichannels and inhibit, or activate, channel opening are provided. In certain aspects, methods for detecting or treating cancers with antibodies that activate Cx43 channel opening are also provided. Likewise, methods for treating inflammatory diseases (e.g., osteoarthritis) and neurological injuries (e.g., spinal cord injury) with antibodies that inhibit Cx43 channel opening arc provided.

2.

发明授权
Methods for treating inflammatory disorders or cancer metastasis by administering antibodies to connexin 43 (Cx43) hemichannels 有权

公开(公告)号：US09914775B2

公开(公告)日：2018-03-13

申请号：US14912986

申请日：2014-08-21

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Jean X. Jiang , Manuel A. Riquelme , Sumin Gu

IPC: C07K16/28 , A61K49/00 , G01N33/50

CPC classification number: C07K16/28 , A61K49/0008 , C07K2317/76 , G01N33/5032

Abstract: Methods for identifying compounds that positively regulate connexin 43 hemichannels.

3.

发明授权
Methods of treating an osteolytic tumor and spinal cord injury by administering connexin (Cx) 43 hemichannel-binding antibodies 有权

公开(公告)号：US10889637B2

公开(公告)日：2021-01-12

申请号：US16078990

申请日：2017-02-27

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Jean X. Jiang , Zhiqiang An , Ningyan Zhang , Wei Xiong , Manuel A. Riquelme , Sumin Gu , Naomi Ledene Sayre

IPC: C07K16/18 , A61P25/28 , A61P19/10 , A61K39/395 , A61P35/00

Abstract: Antibodies that bind to connexin 43 hemichannels and inhibit, or activate, channel opening are provided. In certain aspects, methods for detecting or treating cancers with antibodies that activate Cx43 channel opening are also provided. Likewise, methods for treating inflammatory diseases (e.g., osteoarthritis) and neurological injuries (e.g., spinal cord injury) with antibodies that inhibit Cx43 channel opening are provided.

4.

发明授权
Methods of treating metastasis, including inhibiting bone cancer metastasis, by administering an antibody which binds connexin 43 (Cx43) hemichannel 有权

公开(公告)号：US11912758B2

公开(公告)日：2024-02-27

申请号：US17146187

申请日：2021-01-11

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Jean X. Jiang , Zhiqiang An , Ningyan Zhang , Wei Xiong , Manuel A. Riquelme , Sumin Gu , Naomi Ledene Sayre

IPC: C07K16/18 , A61K39/395 , A61P35/00 , A61P25/28 , A61P19/10

CPC classification number: C07K16/18 , A61K39/395 , A61P19/10 , A61P25/28 , A61P35/00 , C07K2317/24 , C07K2317/75 , C07K2317/76

Abstract: Antibodies that bind to connexin 43 hemichannels and inhibit, or activate, channel opening are provided. In certain aspects, methods for detecting or treating cancers with antibodies that activate Cx43 channel opening are also provided. Likewise, methods for treating inflammatory diseases (e.g., osteoarthritis) and neurological injuries (e.g., spinal cord injury) with antibodies that inhibit Cx43 channel opening are provided.

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