-
公开(公告)号：US12115200B2
公开(公告)日：2024-10-15
申请号：US17290516
申请日：2019-04-30
发明人： Dong-Hyun Kim , Myung Joo Han
IPC分类号： A61K35/745 , A61K35/747 , A61P3/04 , A61P19/10 , A61P25/24 , C12N1/20 , A61K35/00 , C12R1/25
CPC分类号： A61K35/745 , A61K35/747 , A61P3/04 , A61P19/10 , A61P25/24 , C12N1/20 , A61K2035/115 , C12R2001/25
摘要： The present disclosure relates to Lactobacillus plantarum NK3 and Bifidobacterium longum NK49, which are novel lactic acid bacteria, and, more particularly, to a composition comprising novel lactic acid bacteria that are useful for the prevention or treatment of female menopausal disorders.
-
公开(公告)号：US12083154B1
公开(公告)日：2024-09-10
申请号：US18661900
申请日：2024-05-13
CPC分类号： A61K36/53 , A61P19/10 , A61K2236/15 , A61K2236/17 , A61K2236/31 , A61K2236/33
摘要： The composition for treating bone loss is an alcoholic extract of Lavandula atriplicifolia plant flowers and leaves. The composition is prepared by extracting dried Lavandula plant flower and leaf powder in ethanol or methanol for at least 4 hours in a Soxhlet apparatus. The Lavandula atriplicifolia extract acts by both stimulating osteogenesis and inhibiting adipogenesis. The composition may be used to form drug compositions for treating bone loss.
-
公开(公告)号：US20240293448A1
公开(公告)日：2024-09-05
申请号：US18116820
申请日：2023-03-02
CPC分类号： A61K33/38 , A61K9/5192 , A61K36/24 , A61P19/10 , B82Y5/00 , A61K2236/333 , A61K2236/53
摘要： The composition for treating bone loss is a solution of silver nanoparticles in an ethanolic extract of Leptadenia plant leaves. The composition is prepared by extracting dried Leptadenia plant leaf powder in ethanol for 24 hours at room temperature with constant stirring. A sample of the extract is fractionated by column chromatography, and the fractions are tested to determine the most effective fraction for stimulating osteoblast formation from bone marrow-derived mesenchymal stem cells (BMSCs). This fraction is used to synthesize green silver nanoparticles by adding the extract fraction to a solution of silver nitrate with constant stirring for 24 hours at room temperature. A portion of the Leptadenia extract is added to the resulting silver nanoparticles to stimulate osteoblast formation in cultures of BMSCs. The composition may be used to form drug compositions for treating bone loss.
-
公开(公告)号：US20240254219A1
公开(公告)日：2024-08-01
申请号：US18693416
申请日：2022-09-20
发明人： Bin LIU , Nam-Kyung LEE , Scott BIDLINGMAIER , Yang SU
CPC分类号： C07K16/28 , A61P19/10 , C12N15/1037 , C12N15/1055 , A61K2039/505 , C07K2317/21 , C07K2317/75
摘要： Antibodies are provided herein that agonize Wnt signaling, do not compete with a Wnt ligand for LRP6 binding, and activate Wnt signaling in the presence of inhibitors. Methods for promoting cell differentiation and tissue regeneration using the disclosed antibodies are also provided.
-
公开(公告)号：US20240252559A1
公开(公告)日：2024-08-01
申请号：US18561110
申请日：2022-03-22
IPC分类号： A61K35/747 , A61P19/10
CPC分类号： A61K35/747 , A61P19/10
摘要： A problem to be solved by the present invention is to provide a composition (1) for inhibiting differentiation of osteoclast precursor cells into osteoclasts, improving bone metabolism, and/or inhibiting bone density reduction, the composition (1) including a culture supernatant or a processed product thereof, the culture supernatant being obtainable by culturing immune cells in the presence of lactic acid bacteria or a processed product thereof, or a composition (2) for inhibiting differentiation of osteoclast precursor cells into osteoclasts, improving bone metabolism, and/or inhibiting bone density reduction, the composition (2) including Lactobacillus plantarum strain L-137 (Lactobacillus plantarum L-137) or a processed product thereof. These compositions solve the problem.
-
公开(公告)号：US20240182504A1
公开(公告)日：2024-06-06
申请号：US18535218
申请日：2023-12-11
申请人： BIOVINC, LLC
发明人： Frank H. EBETINO , Shuting SUN , Philip T. CHERIAN
IPC分类号： C07F9/6558 , A61K47/54 , A61K47/55 , A61P19/10 , A61P31/04 , C07F9/6561
CPC分类号： C07F9/65583 , A61K47/548 , A61K47/55 , A61K47/552 , A61P19/10 , A61P31/04 , C07F9/6561
摘要： Described herein are bisphosphonate quinolone compounds, conjugates and pharmaceutical formulations thereof that can include a bisphosphonate and a quinolone, where the quinolone can be releasably coupled to the bisphosphonate. Also provided herein are methods of making and methods of using the bisphosphonate quinolone compounds, conjugates and pharmaceutical formulations thereof.
-
公开(公告)号：US11912752B2
公开(公告)日：2024-02-27
申请号：US17243589
申请日：2021-04-29
申请人： Dehong Yang
发明人： Dehong Yang
IPC分类号： C07K14/635 , A61P19/10 , A61K38/00
CPC分类号： C07K14/635 , A61P19/10 , A61K38/00
摘要： A novel PTH(1-34) mimetic peptide based on protein domain reconstruction. The mimetic peptide contains peptide fragment repeats at 29th-34th positions. The amino acid at the 34th position and the last amino acid of the peptide fragment repeats at the 29th-34th positions are changed from phenylalanine (Phe, F) into tyrosine (Tyr, Y), so that MY-3 peptide is formed. Preclinical experiments show that the MY-3 mimetic peptide promotes osteoblast differentiation and has a very good effect in treating osteoporosis and promoting bone growth. The anti-osteoporosis effect of the MY-3 mimetic peptide is better than that of the PTH (1-34) (The product name on the market is Forsteo or Parathyroid), so that the MY-3 mimetic peptide has a significant clinical application prospect.
-
公开(公告)号：US11903949B2
公开(公告)日：2024-02-20
申请号：US16539894
申请日：2019-08-13
发明人： Debra Ellies , F. Scott Kimball , Robert N. Young
IPC分类号： C07D471/04 , C07D498/08 , C07D491/048 , A61K31/5377 , A61K39/395 , A61K31/444 , A61K31/496 , A61K35/32 , A61K31/5386 , A61P19/10 , A61K31/55
CPC分类号： A61K31/5377 , A61K31/444 , A61K31/496 , A61K31/5386 , A61K31/55 , A61K35/32 , A61K39/3955 , A61P19/10 , C07D471/04 , C07D491/048 , C07D498/08
摘要： In one aspect, the invention provides compounds of Formula I, and salts, hydrates and isomers thereof. In another aspect, the invention provides a method of promoting bone formation in a subject in need thereof by administering to the subject a therapeutically effective amount of a compound of Formula I. The present invention also provides orthopedic and periodontal devices, as well as methods for the treatment of renal disease, diabetes, bone loss, and cancer, using a compound of Formula I.
-
公开(公告)号：US20230321155A1
公开(公告)日：2023-10-12
申请号：US18295945
申请日：2023-04-05
发明人： Zhifeng YU , Wenjie ZHANG
CPC分类号： A61K35/35 , A61K38/30 , A61K38/185 , A61K38/1825 , A61K38/1866 , A61K38/1841 , A61K38/1833 , A61K38/1858 , A61P19/10
摘要： A cell-free fat extract may be used for treating osteoporosis. Specifically, the cell-free fat extract can be used to prepare a composition or preparation for preventing and/or treating osteoporosis, in particular osteoporosis due to estrogenic decline. The cell-free fat extract inhibits osteoblast differentiation and osteoclast differentiation, inhibits fusion of the bone marrow macrophage skeleton, improves the structure of hind limb bone, alleviates bone loss and attenuate bone resorption, and improves the mechanical properties of the femur.
-
公开(公告)号：US20230293649A1
公开(公告)日：2023-09-21
申请号：US18019052
申请日：2021-08-02
申请人： BioVentures, LLC
摘要： The present invention provides methods of treating bone loss or cancer using CST6. In these methods, CST6 may be provided as a recombinant CST6 protein, a polynucleotide construct comprising CST6, or an immune cell expressing CST6 protein.
-
-
-
-
-
-
-
-
-
搜索结果
142 条记录 (耗时 0.022 秒)
