公开(公告)号：US10377701B2

公开(公告)日：2019-08-13

申请号：US15807306

申请日：2017-11-08

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Nagichettiar Satyamurthy ,  Jie Liu ,  Jorge R. Barrio

IPC: C07C253/30 ,  C07B59/00 ,  C07C253/34 ,  C07C255/34

Abstract: A method of manufacturing 2-(1-{6-[(2-[F-18]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)-malononitrile ([F-18]FDDNP) utilizes a semi-automated module that is used to perform fluorination, pre-purification, separation, product extraction, and formulation. The method is able to produce [F-18]FDDNP with high yields and ready for human administration under existing FDA regulations, and without the need for hazardous organic solvents such as dichloromethane (DCM), methanol (MeOH), and tetrahydrofuran (THF). The method also improves the speed with which [F-18]FDDNP can be synthesized with the method being able to generate a final product within about 90 to 100 minutes. This synthesis method is easily adaptable to FDA registered and approved automated synthesis systems.

公开(公告)号：US20180127355A1

公开(公告)日：2018-05-10

申请号：US15807306

申请日：2017-11-08

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Nagichettiar Satyamurthy ,  Jie Liu ,  Jorge R. Barrio

IPC: C07C253/30 ,  C07B59/00 ,  C07C253/34 ,  C07C255/34

CPC classification number: C07C253/30 ,  C07B59/001 ,  C07B2200/05 ,  C07C253/34 ,  C07C255/34 ,  C07C255/42

Abstract: A method of manufacturing 2-(1-{6-[(2-[F-18]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)-malononitrile ([F-18]FDDNP) utilizes a semi-automated module that is used to perform fluorination, pre-purification, separation, product extraction, and formulation. The method is able to produce [F-18]FDDNP with high yields and ready for human administration under existing FDA regulations, and without the need for hazardous organic solvents such as dichloromethane (DCM), methanol (MeOH), and tetrahydrofuran (THF). The method also improves the speed with which [F-18]FDDNP can be synthesized with the method being able to generate a final product within about 90 to 100 minutes. This synthesis method is easily adaptable to FDA registered and approved automated synthesis systems.

公开(公告)号：US20190322616A1

公开(公告)日：2019-10-24

申请号：US16457322

申请日：2019-06-28

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Nagichettiar Satyamurthy ,  Jie Liu ,  Jorge R. Barrio

IPC: C07C253/30 ,  C07C255/34 ,  C07C253/34 ,  C07B59/00

Abstract: A method of manufacturing 2-(1-{6-[(2-[F-18]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)-malononitrile ([F-18]FDDNP) utilizes a semi-automated module that is used to perform fluorination, pre-purification, separation, product extraction, and formulation. The method is able to produce [F-18]FDDNP with high yields and ready for human administration under existing FDA regulations, and without the need for hazardous organic solvents such as dichloromethane (DCM), methanol (MeOH), and tetrahydrofuran (THF). The method also improves the speed with which [F-18]FDDNP can be synthesized with the method being able to generate a final product within about 90 to 100 minutes. This synthesis method is easily adaptable to FDA registered and approved automated synthesis systems.