公开(公告)号：US20200055816A1

公开(公告)日：2020-02-20

申请号：US16555710

申请日：2019-08-29

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Mark MASCAL ,  Saikat DUTTA ,  Linglin WU

IPC: C07C407/00 ,  C07C409/16 ,  C07C59/01 ,  C07C55/10 ,  C07B41/14 ,  C07B41/08 ,  C07C51/367 ,  C07C51/285

Abstract: The present invention provides a method of making carboxylic acids from levulinic acid, such as succinic acid and 3-hydroxypropanoic acid, by reacting levulinic acid with an oxidant such as hydrogen peroxide under acidic or basic conditions.

公开(公告)号：US20220183998A1

公开(公告)日：2022-06-16

申请号：US17436015

申请日：2020-03-09

Applicant: The Regents of the University of California

Inventor： Mark MASCAL ,  Nikolay SHEVCHENKO

IPC: A61K31/05 ,  A61P25/08

Abstract: The present invention provides a method of treating or mitigating seizures comprising compounds as described herein.

公开(公告)号：US20150376153A1

公开(公告)日：2015-12-31

申请号：US14852134

申请日：2015-09-11

Applicant: MICROMIDAS, INC. ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Makoto N. MASUNO ,  Saikat DUTTA ,  Mark MASCAL

IPC: C07D307/36

CPC classification number: C07D307/36 ,  C07D307/52 ,  Y02P20/582

Abstract: Provided herein are methods for preparing alkylfurans, such as 2,5-dialkylfurans and 2-alkylfurans. Furfural or 5-alkylfurfural can be reacted with aniline or diaminobenzene, or derivatives thereof, to form the corresponding imine, which can be reduced to form alkylfurans and to regenerate the aniline or diaminobenzene, or derivatives thereof. The alkylfuran may be, for example, 2,5-dimethylfuran or 2-methylfuran.

Abstract translation: 本文提供了制备烷基呋喃的方法，例如2,5-二烷基呋喃和2-烷基呋喃。 糠醛或5-烷基糠醛可以与苯胺或二氨基苯或其衍生物反应形成相应的亚胺，其可以还原形成烷基呋喃并使苯胺或二氨基苯或其衍生物再生。 烷基呋喃可以是例如2,5-二甲基呋喃或2-甲基呋喃。

公开(公告)号：US20250009766A1

公开(公告)日：2025-01-09

申请号：US18706266

申请日：2022-11-01

Applicant: The Regents of the University of California

Inventor： Michael ROGAWSKI ,  Ashish DHIR ,  Mark MASCAL

IPC: A61K31/00 ,  A61P25/08

Abstract: The present invention provides a method of treating or mitigating seizures or epilepsy comprising compounds as described herein.

公开(公告)号：US20240018160A1

公开(公告)日：2024-01-18

申请号：US17753902

申请日：2020-09-21

Applicant: BASF SE ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Mark MASCAL ,  Jan SASKA ,  Alois KINDLER ,  Stephan ZUEND ,  Saikat DUTTA

IPC: C07D493/04

CPC classification number: C07D493/04 ,  C07B2200/07

Abstract: Disclosed herein is a method of making and/or isolating isoidide, a composition including a mixture including non-esterified isoidide and one or both compounds selected from the group consisting of esterified isosorbide and esterified isomannide and a method of using of such composition for making and/or isolating isoidide. Further disclosed herein is a method including a step of selective esterification of a mixture of dianhydrohexitol isomers including isoidide for separating isoidide from said mixture of dianhydrohexitol isomers. Moreover, a method of making a polymer including isoidide monomers or modified isoidide monomers is disclosed.