公开(公告)号：US20240190880A1

公开(公告)日：2024-06-13

申请号：US18279236

申请日：2022-03-04

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Shaomeng Wang ,  Zhixiang Chen ,  Rohan Rej ,  Dimin Wu ,  Jianfeng Lu ,  Biao Hu ,  Mingliang Wang ,  Ranjan Kumar Acharyya

IPC: C07D487/04 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/4709 ,  C07D519/00

CPC classification number: C07D487/04 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/4709 ,  C07D519/00

Abstract: The present disclosure relates to compounds of Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein A, X, J, Y, Z, n, and B 1 are as defined as set forth in the specification. The present disclosure also relates to uses of the compounds, e.g., in treating preventing a condition or disorder responsive to the degradation of estrogen receptor protein (e.g., cancer).