公开(公告)号：US20240190880A1

公开(公告)日：2024-06-13

申请号：US18279236

申请日：2022-03-04

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Shaomeng Wang ,  Zhixiang Chen ,  Rohan Rej ,  Dimin Wu ,  Jianfeng Lu ,  Biao Hu ,  Mingliang Wang ,  Ranjan Kumar Acharyya

IPC: C07D487/04 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/4709 ,  C07D519/00

CPC classification number: C07D487/04 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/4709 ,  C07D519/00

Abstract: The present disclosure relates to compounds of Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein A, X, J, Y, Z, n, and B 1 are as defined as set forth in the specification. The present disclosure also relates to uses of the compounds, e.g., in treating preventing a condition or disorder responsive to the degradation of estrogen receptor protein (e.g., cancer).

公开(公告)号：US20220079931A1

公开(公告)日：2022-03-17

申请号：US17420417

申请日：2019-12-19

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Shaomeng Wang ,  Jiantao Hu ,  Biao Hu ,  Mingliang Wang ,  Fuming Xu ,  Bukeyan Miao

IPC: A61K31/454 ,  A61K31/381 ,  A61K47/54 ,  A61K31/427 ,  A61K31/40 ,  A61P35/00 ,  A61K31/337 ,  A61K31/566 ,  A61K31/7068 ,  A61K31/704 ,  A61K31/513 ,  A61K31/475 ,  A61K31/138 ,  A61K31/519 ,  A61K31/565

Abstract: The present disclosure provides compounds represented by Formula (I): A-L-B and the salts or solvates thereof, wherein A, L, and B are as defined in the specification. Compounds having Formula I are estrogen receptor degraders useful for the treatment of cancer.