公开(公告)号：US11260150B2

公开(公告)日：2022-03-01

申请号：US16726750

申请日：2019-12-24

Applicant: Tangible Science, Inc.

Inventor： Karen Havenstrite ,  Victor W. McCray ,  Brandon M. Felkins ,  Paul Cook

IPC: A61L29/14 ,  A61L27/52 ,  A61L27/54 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/14 ,  A61L15/60 ,  A61L27/34 ,  A61L31/16 ,  A61L15/46

Abstract: Medical devices with a hydrogel layer covalently attached to a portion of the outer surface of the medical device are provided along with methods for applying the coating. The hydrogel layer can include a first polymer species comprising polyethylene glycol (PEG) and a second polymer species. Examples of the second polymer species include PEG and polyacrylamide (PAM). The first and second species can be at least partially cross-linked. Methods for forming the hydrogel coatings on the medical devices are provided including nucleophilic conjugate reactions, such as Click reactions.