公开(公告)号：US20160195549A1

公开(公告)日：2016-07-07

申请号：US15061329

申请日：2016-03-04

申请人： The Trustees of the University of Pennsylvania

发明人： John Robert Pollard ,  Peter B. Crino

IPC分类号： G01N33/68

CPC分类号： G01N33/6896 ,  A61K38/1709 ,  G01N33/543 ,  G01N2333/521 ,  G01N2333/705 ,  G01N2333/70503 ,  G01N2333/70525 ,  G01N2800/2857

摘要： The application relates to markers for seizures and epilepsy. Polypeptide expression panels or arrays are provided, comprising one or more probes capable of binding specific polypeptides in blood plasma or blood serum of a mammalian subject. Also provided are methods for detecting seizure, methods for predicting seizure, use of sICAM-5 in the treatment of seizure, methods for assessing the effectiveness of a treatment of seizure, and diagnostic kits.

公开(公告)号：US20180259540A1

公开(公告)日：2018-09-13

申请号：US15977385

申请日：2018-05-11

申请人： The Trustees of the University of Pennsylvania

发明人： John Robert Pollard ,  Peter B. Crino

IPC分类号： G01N33/68 ,  G01N33/543 ,  A61K38/17

CPC分类号： G01N33/6896 ,  A61K38/1709 ,  G01N33/543 ,  G01N2333/521 ,  G01N2333/705 ,  G01N2333/70503 ,  G01N2333/70525 ,  G01N2800/2857

摘要： The application relates to markers for seizures and epilepsy. Polypeptide expression panels or arrays are provided, comprising one or more probes capable of binding specific polypeptides in blood plasma or blood serum of a mammalian subject. Also provided are methods for detecting seizure, methods for predicting seizure, use of sICAM-5 in the treatment of seizure, methods for assessing the effectiveness of a treatment of seizure, and diagnostic kits.

公开(公告)号：US20160139153A1

公开(公告)日：2016-05-19

申请号：US14943101

申请日：2015-11-17

申请人： The Trustees of the University of Pennsylvania

发明人： John Robert Pollard ,  Peter B. Crino

IPC分类号： G01N33/68

CPC分类号： G01N33/6896 ,  A61K38/1709 ,  G01N33/543 ,  G01N2333/521 ,  G01N2333/705 ,  G01N2333/70503 ,  G01N2333/70525 ,  G01N2800/2857

摘要： The application relates to markers for seizures and epilepsy. Polypeptide expression panels or arrays are provided, comprising one or more probes capable of binding specific polypeptides in blood plasma or blood serum of a mammalian subject. Also provided are methods for detecting seizure, methods for predicting seizure, use of sICAM-5 in the treatment of seizure, methods for assessing the effectiveness of a treatment of seizure, and diagnostic kits.

公开(公告)号：US11035866B2

公开(公告)日：2021-06-15

申请号：US15977385

申请日：2018-05-11

申请人： The Trustees of the University of Pennsylvania

发明人： John Robert Pollard ,  Peter B. Crino

IPC分类号： G01N33/68 ,  G01N33/543 ,  A61K38/17

摘要： The application relates to markers for seizures and epilepsy. Polypeptide expression panels or arrays are provided, comprising one or more probes capable of binding specific polypeptides in blood plasma or blood serum of a mammalian subject. Also provided are methods for detecting seizure, methods for predicting seizure, use of sICAM-5 in the treatment of seizure, methods for assessing the effectiveness of a treatment of seizure, and diagnostic kits.

公开(公告)号：US09983219B2

公开(公告)日：2018-05-29

申请号：US15678784

申请日：2017-08-16

申请人： The Trustees of the University of Pennsylvania

发明人： John Robert Pollard ,  Peter B. Crino

IPC分类号： G01N33/68 ,  A61K38/00 ,  G01N33/543 ,  A61K38/17

CPC分类号： G01N33/6896 ,  A61K38/1709 ,  G01N33/543 ,  G01N2333/521 ,  G01N2333/705 ,  G01N2333/70503 ,  G01N2333/70525 ,  G01N2800/2857

摘要： The application relates to markers for seizures and epilepsy. Polypeptide expression panels or arrays are provided, comprising one or more probes capable of binding specific polypeptides in blood plasma or blood serum of a mammalian subject. Also provided are methods for detecting seizure, methods for predicting seizure, use of sICAM-5 in the treatment of seizure, methods for assessing the effectiveness of a treatment of seizure, and diagnostic kits.

公开(公告)号：US20170343565A1

公开(公告)日：2017-11-30

申请号：US15678784

申请日：2017-08-16

申请人： The Trustees of the University of Pennsylvania

发明人： John Robert Pollard ,  Peter B. Crino

IPC分类号： G01N33/68 ,  A61K38/17 ,  G01N33/543

CPC分类号： G01N33/6896 ,  A61K38/1709 ,  G01N33/543 ,  G01N2333/521 ,  G01N2333/705 ,  G01N2333/70503 ,  G01N2333/70525 ,  G01N2800/2857

摘要： The application relates to markers for seizures and epilepsy. Polypeptide expression panels or arrays are provided, comprising one or more probes capable of binding specific polypeptides in blood plasma or blood serum of a mammalian subject. Also provided are methods for detecting seizure, methods for predicting seizure, use of sICAM-5 in the treatment of seizure, methods for assessing the effectiveness of a treatment of seizure, and diagnostic kits.

公开(公告)号：US09772335B2

公开(公告)日：2017-09-26

申请号：US15061329

申请日：2016-03-04

申请人： The Trustees of the University of Pennsylvania

发明人： John Robert Pollard ,  Peter B. Crino

IPC分类号： A61K39/00 ,  A61K38/39 ,  G01N33/68 ,  A61K38/17 ,  G01N33/543

CPC分类号： G01N33/6896 ,  A61K38/1709 ,  G01N33/543 ,  G01N2333/521 ,  G01N2333/705 ,  G01N2333/70503 ,  G01N2333/70525 ,  G01N2800/2857

摘要： The application relates to markers for seizures and epilepsy. Polypeptide expression panels or arrays are provided, comprising one or more probes capable of binding specific polypeptides in blood plasma or blood serum of a mammalian subject. Also provided are methods for detecting seizure, methods for predicting seizure, use of sICAM-5 in the treatment of seizure, methods for assessing the effectiveness of a treatment of seizure, and diagnostic kits.