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公开(公告)号：US11471460B2
公开(公告)日：2022-10-18
申请号：US16883046
申请日：2020-05-26
申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services
IPC分类号： A61K31/53 , A61P35/00 , A61K31/506 , C07D239/50 , C07D251/54 , C07D403/12
摘要： Disclosed is method for treating cancer in a mammal, comprising administering to a mammal in need thereof a compound of the formula: wherein R1, R2, and R3 are as defined herein, wherein the cancer is an autophagy-dependent cancer, in an amount sufficient to induce autophagy in the cell and cause the death of cancer cells. Also disclosed is a method for selectively killing cancer cells in a patient afflicted with cancer, comprising administering to the mammal, wherein the cancer cells are autophagy-dependent cancer cells, in an amount sufficient to induce autophagy in the cells and cause the death of the cancer cells.
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公开(公告)号：US20200369649A1
公开(公告)日：2020-11-26
申请号：US16883046
申请日：2020-05-26
申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services
IPC分类号： C07D403/12 , C07D251/54 , C07D239/50 , A61P35/00
摘要： Disclosed is method for treating cancer in a mammal, comprising administering to a mammal in need thereof a compound of the formula: wherein R1, R2, and R3 are as defined herein, wherein the cancer is an autophagy-dependent cancer, in an amount sufficient to induce autophagy in the cell and cause the death of cancer cells. Also disclosed is a method for selectively killing cancer cells in a patient afflicted with cancer, comprising administering to the mammal, wherein the cancer cells are autophagy-dependent cancer cells, in an amount sufficient to induce autophagy in the cells and cause the death of the cancer cells.
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