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13 条记录 (耗时 0.016 秒)

    Method for providing neuroprotection from spinal muscular atrophy
    1.
    发明授权
    Method for providing neuroprotection from spinal muscular atrophy 有权
    从脊髓性肌萎缩提供神经保护的方法

    公开(公告)号：US08354395B2

    公开(公告)日：2013-01-15

    申请号：US13591789

    申请日：2012-08-22

    申请人： Thierry Bordet ,  Cyrille Drouot ,  Bruno Buisson

    发明人： Thierry Bordet ,  Cyrille Drouot ,  Bruno Buisson

    IPC分类号： A61K31/375 ,  C07J9/00 ,  C07J41/00

    CPC分类号： C07J9/00 ,  A61K31/575

    摘要： A method for providing neuroprotection to a patient in need of neuroprotection, comprising administering a neuroprotective-effective amount of a compound of formula I in which X is an oxygen atom or an ═N—OH group, R is selected from the group consisting of A is a hydrogen atom or together with B a carbon-carbon bond, B is a hydrogen atom, a hydroxy group or together with A a carbon-carbon bond, C is a hydrogen atom or together with D a carbon-carbon bond, D is a hydrogen atom or together with C a carbon-carbon bond, E is a hydrogen atom or together with F a carbon-carbon bond, F is a hydrogen atom or together with E a carbon-carbon bond, or an addition salt with a pharmaceutically acceptable acid.

    摘要翻译： 一种向需要神经保护的患者提供神经保护的方法，包括给予神经保护有效量的其中X为氧原子或= N-OH基团的式I化合物，R选自A 是氢原子或与B一起形成碳 - 碳键，B为氢原子，羟基或与A为碳 - 碳键，C为氢原子，或与D为碳 - 碳键，D为 氢原子或与碳碳键一起，E为氢原子，或与F为碳 - 碳键，F为氢原子，或与碳为碳原子一起形成，或与药物上的加成盐 可接受的酸。

    Use as medicaments of derivatives of cholest-4-en-3-one, pharmaceutical compositions containing them, novel derivatives and their preparation process
    3.
    发明授权
    Use as medicaments of derivatives of cholest-4-en-3-one, pharmaceutical compositions containing them, novel derivatives and their preparation process 有权
    用作胆固醇-4-烯-3-酮衍生物的药物，含有它们的药物组合物，新型衍生物及其制备方法

    公开(公告)号：US08283341B2

    公开(公告)日：2012-10-09

    申请号：US12776217

    申请日：2010-05-07

    申请人： Thierry Bordet ,  Cyrille Drouot ,  Bruno Buisson

    发明人： Thierry Bordet ,  Cyrille Drouot ,  Bruno Buisson

    IPC分类号： A61K31/375 ,  C07J9/00 ,  C07J41/00

    CPC分类号： C07J9/00 ,  A61K31/575

    摘要： A method for providing neuroprotection to a patient in need of neuroprotection, comprising administering a neuroprotective-effective amount of a compound of formula I in which X is an oxygen atom or an ═N—OH group, R is selected from the group consisting of A is a hydrogen atom or together with B a carbon-carbon bond, B is a hydrogen atom, a hydroxy group or together with A a carbon-carbon bond, C is a hydrogen atom or together with D a carbon-carbon bond, D is a hydrogen atom or together with C a carbon-carbon bond, E is a hydrogen atom or together with F a carbon-carbon bond, F is a hydrogen atom or together with E a carbon-carbon bond, or an addition salt with a pharmaceutically acceptable acid.

    摘要翻译： 一种向需要神经保护的患者提供神经保护的方法，包括给予神经保护有效量的其中X为氧原子或= N-OH基团的式I化合物，R选自A 是氢原子或与B一起形成碳 - 碳键，B为氢原子，羟基或与A为碳 - 碳键，C为氢原子，或与D为碳 - 碳键，D为 氢原子或与碳碳键一起，E为氢原子，或与F为碳 - 碳键，F为氢原子，或与碳为碳原子一起形成，或与药物上的加成盐 可接受的酸。

    Method for providing neuroprotection
    4.
    发明授权
    Method for providing neuroprotection 有权
    提供神经保护的方法

    公开(公告)号：US08575138B2

    公开(公告)日：2013-11-05

    申请号：US13591774

    申请日：2012-08-22

    申请人： Thierry Bordet ,  Cyrille Drouot ,  Bruno Buisson

    发明人： Thierry Bordet ,  Cyrille Drouot ,  Bruno Buisson

    IPC分类号： A61K31/575 ,  A61P35/00 ,  A61P25/00

    CPC分类号： C07J9/00 ,  A61K31/575

    摘要： A method for providing neuroprotection to a patient in need of neuroprotection, comprising administering a neuroprotective-effective amount of a compound of formula I in which X is an oxygen atom or an ═N—OH group, R is selected from the group consisting of A is a hydrogen atom or together with B a carbon-carbon bond, B is a hydrogen atom, a hydroxy group or together with A a carbon-carbon bond, C is a hydrogen atom or together with D a carbon-carbon bond, D is a hydrogen atom or together with C a carbon-carbon bond, E is a hydrogen atom or together with F a carbon-carbon bond, F is a hydrogen atom or together with E a carbon-carbon bond, or an addition salt with a pharmaceutically acceptable acid.

    摘要翻译： 一种向需要神经保护的患者提供神经保护作用的方法，包括给予神经保护有效量的其中X为氧原子或= N-OH基团的式I化合物，R选自A 是氢原子或与B一起形成碳 - 碳键，B为氢原子，羟基或与A为碳 - 碳键，C为氢原子，或与D为碳 - 碳键，D为 氢原子或与碳碳键一起，E为氢原子，或与F为碳 - 碳键，F为氢原子，或与碳为碳原子一起形成，或与药物上的加成盐 可接受的酸。

    METHOD FOR PROVIDING NEUROPROTECTION
    5.
    发明申请
    METHOD FOR PROVIDING NEUROPROTECTION 有权
    提供神经保护的方法

    公开(公告)号：US20120309721A1

    公开(公告)日：2012-12-06

    申请号：US13591774

    申请日：2012-08-22

    申请人： Thierry Bordet ,  Cyrille Drouot ,  Bruno Buisson

    发明人： Thierry Bordet ,  Cyrille Drouot ,  Bruno Buisson

    IPC分类号： A61K31/575 ,  A61P35/00 ,  A61P25/00

    CPC分类号： C07J9/00 ,  A61K31/575

    摘要： A method for providing neuroprotection to a patient in need of neuroprotection, comprising administering a neuroprotective-effective amount of a compound of formula I in which X is an oxygen atom or an =N—OH group,R is selected from the group consisting of A is a hydrogen atom or together with B a carbon-carbon bond,B is a hydrogen atom, a hydroxy group or together with A a carbon-carbon bond,C is a hydrogen atom or together with D a carbon-carbon bond,D is a hydrogen atom or together with C a carbon-carbon bond,E is a hydrogen atom or together with F a carbon-carbon bond,F is a hydrogen atom or together with E a carbon-carbon bond, or an addition salt with a pharmaceutically acceptable acid.

    摘要翻译： 一种向需要神经保护的患者提供神经保护作用的方法，包括给予神经保护有效量的其中X为氧原子或= N-OH基团的式I化合物，R选自A 是氢原子或与B一起形成碳 - 碳键，B为氢原子，羟基或与A为碳 - 碳键，C为氢原子，或与D为碳 - 碳键，D为 氢原子或与碳碳键一起，E为氢原子，或与F为碳 - 碳键，F为氢原子，或与碳为碳原子一起形成，或与药物上的加成盐 可接受的酸。

    Use of derivatives of cholest-4-en-3-one as medicaments, pharmaceutical compositions containing same, novel derivatives and preparation method thereof
    6.
    发明授权
    Use of derivatives of cholest-4-en-3-one as medicaments, pharmaceutical compositions containing same, novel derivatives and preparation method thereof 有权
    胆甾-4-烯-3-酮衍生物作为药物的用途，含有它们的药物组合物，新型衍生物及其制备方法

    公开(公告)号：US07858603B2

    公开(公告)日：2010-12-28

    申请号：US10548473

    申请日：2004-03-05

    申请人： Thierry Bordet ,  Cyrille Drouot ,  Bruno Buisson

    发明人： Thierry Bordet ,  Cyrille Drouot ,  Bruno Buisson

    IPC分类号： A61K31/575 ,  C07J9/00 ,  C07J41/00

    CPC分类号： C07J9/00 ,  A61K31/575

    摘要： Compound of formula I where X=O or ═N—OH group, R represents a group chosen from A=hydrogen or together with B a carbon-carbon bond, B=hydrogen, hydroxy or together with A a carbon-carbon bond, C, D, E, F=hydrogen or together with D a carbon-carbon bond, or the one of its addition salts with pharmaceutically acceptable acids, with the exception of a few compounds, as a medicament, use in particular as neuroprotectors, novel compounds of formula I and pharmaceutical compositions.

    摘要翻译： 式I的化合物，其中X = O或= N-OH基团，R表示选自A =氢或与B一起形成碳 - 碳键的基团，B =氢，羟基或与碳碳键连接，C ，D，E，F =氢或与D一个碳 - 碳键，或其加成盐与药学上可接受的酸之一，除少数化合物外，作为药物，尤其用作神经保护剂，新化合物 的式I和药物组合物。

    Novel Derivatives of 3.5-Seco-4-Norcholestane and Use Thereof
    7.
    发明申请
    Novel Derivatives of 3.5-Seco-4-Norcholestane and Use Thereof 有权
    3.5-Seco-4-Norcholestane的新型衍生物及其用途

    公开(公告)号：US20080275130A1

    公开(公告)日：2008-11-06

    申请号：US11662088

    申请日：2005-08-19

    申请人： Thierry Bordet ,  Cyrille Drouot

    发明人： Thierry Bordet ,  Cyrille Drouot

    IPC分类号： A61K31/15 ,  C07C251/42 ,  A61P25/00

    CPC分类号： C07C251/44 ,  C07C2603/12

    摘要： The invention relates to compounds of formula (I): where X+Y=keto, or X=OH and Y=H, or X+Y=oxime or methyloxime, B=OH and C+D=H, or C+D=C1-C4 linear or branched alkyl, or C=H and D=C1-C4 linear or branched alkyl, or B+C=keto and D=methyl, hydroxyl, or methylamino, or B and C=H and D=methylamino, or B+C=oxime and D=methyl and R=C1-C10 linear or branched alkyl, the salts, esters, or salts of esters thereof as medicament, in particular as neuroprotectors, novel compounds of formula (I) and pharmaceutical compositions.

    摘要翻译： 本发明涉及式（I）化合物：其中X + Y =酮基，或X = OH和Y = H，或X + Y =肟或甲基肟，B = OH和C + D = H或C + D 或C = H和D = C 1 -C 4直链或支链烷基，或B + C =酮基，D =甲基，羟基或甲基氨基，或B和C = H和D =甲基氨基 ，或B + C =肟和D =甲基，R = C 1 -C 10直链或支链烷基，其酯，酯或其盐作为药物，特别是作为神经保护剂，新的式（I）化合物和药物组合物 。

    Derivatives of 3.5-seco-4-norcholestane and use thereof
    8.
    发明授权
    Derivatives of 3.5-seco-4-norcholestane and use thereof 有权
    3.5-seco-4-norcholestane的衍生物及其用途

    公开(公告)号：US09045393B2

    公开(公告)日：2015-06-02

    申请号：US11662088

    申请日：2005-08-19

    申请人： Thierry Bordet ,  Cyrille Drouot

    发明人： Thierry Bordet ,  Cyrille Drouot

    IPC分类号： A61K31/15 ,  C07C251/44

    CPC分类号： C07C251/44 ,  C07C2603/12

    摘要： The invention relates to compounds of formula (I): where X+Y=keto, or X=OH and Y=H, or X+Y=oxime or methyloxime, B=OH and C+D=H, or C+D=C1-C4 linear or branched alkyl, or C=H and D=C1-C4 linear or branched alkyl, or B+C=keto and D=methyl, hydroxyl, or methylamino, or B and C=H and D=methylamino, or B+C=oxime and D=methyl and R=C1-C10 linear or branched alkyl, the salts, esters, or salts of esters thereof as medicament, in particular as neuroprotectors, novel compounds of formula (I) and pharmaceutical compositions.

    摘要翻译： 本发明涉及式（I）化合物：其中X + Y =酮基，或X = OH和Y = H，或X + Y =肟或甲基肟，B = OH和C + D = H或C + D 或C = H和D = C 1 -C 4直链或支链烷基，或B + C =酮基，D =甲基，羟基或甲基氨基，或B和C = H和D =甲基氨基 ，或B + C =肟和D =甲基，R = C 1 -C 10直链或支链烷基，其酯，酯或其盐作为药物，特别是作为神经保护剂，新的式（I）化合物和药物组合物 。