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19 条记录 (耗时 0.016 秒)

    Method for providing neuroprotection from spinal muscular atrophy
    1.
    发明授权
    Method for providing neuroprotection from spinal muscular atrophy 有权
    从脊髓性肌萎缩提供神经保护的方法

    公开(公告)号：US08354395B2

    公开(公告)日：2013-01-15

    申请号：US13591789

    申请日：2012-08-22

    申请人： Thierry Bordet ,  Cyrille Drouot ,  Bruno Buisson

    发明人： Thierry Bordet ,  Cyrille Drouot ,  Bruno Buisson

    IPC分类号： A61K31/375 ,  C07J9/00 ,  C07J41/00

    CPC分类号： C07J9/00 ,  A61K31/575

    摘要： A method for providing neuroprotection to a patient in need of neuroprotection, comprising administering a neuroprotective-effective amount of a compound of formula I in which X is an oxygen atom or an ═N—OH group, R is selected from the group consisting of A is a hydrogen atom or together with B a carbon-carbon bond, B is a hydrogen atom, a hydroxy group or together with A a carbon-carbon bond, C is a hydrogen atom or together with D a carbon-carbon bond, D is a hydrogen atom or together with C a carbon-carbon bond, E is a hydrogen atom or together with F a carbon-carbon bond, F is a hydrogen atom or together with E a carbon-carbon bond, or an addition salt with a pharmaceutically acceptable acid.

    摘要翻译： 一种向需要神经保护的患者提供神经保护的方法，包括给予神经保护有效量的其中X为氧原子或= N-OH基团的式I化合物，R选自A 是氢原子或与B一起形成碳 - 碳键，B为氢原子，羟基或与A为碳 - 碳键，C为氢原子，或与D为碳 - 碳键，D为 氢原子或与碳碳键一起，E为氢原子，或与F为碳 - 碳键，F为氢原子，或与碳为碳原子一起形成，或与药物上的加成盐 可接受的酸。

    Use as medicaments of derivatives of cholest-4-en-3-one, pharmaceutical compositions containing them, novel derivatives and their preparation process
    3.
    发明授权
    Use as medicaments of derivatives of cholest-4-en-3-one, pharmaceutical compositions containing them, novel derivatives and their preparation process 有权
    用作胆固醇-4-烯-3-酮衍生物的药物，含有它们的药物组合物，新型衍生物及其制备方法

    公开(公告)号：US08283341B2

    公开(公告)日：2012-10-09

    申请号：US12776217

    申请日：2010-05-07

    申请人： Thierry Bordet ,  Cyrille Drouot ,  Bruno Buisson

    发明人： Thierry Bordet ,  Cyrille Drouot ,  Bruno Buisson

    IPC分类号： A61K31/375 ,  C07J9/00 ,  C07J41/00

    CPC分类号： C07J9/00 ,  A61K31/575

    摘要： A method for providing neuroprotection to a patient in need of neuroprotection, comprising administering a neuroprotective-effective amount of a compound of formula I in which X is an oxygen atom or an ═N—OH group, R is selected from the group consisting of A is a hydrogen atom or together with B a carbon-carbon bond, B is a hydrogen atom, a hydroxy group or together with A a carbon-carbon bond, C is a hydrogen atom or together with D a carbon-carbon bond, D is a hydrogen atom or together with C a carbon-carbon bond, E is a hydrogen atom or together with F a carbon-carbon bond, F is a hydrogen atom or together with E a carbon-carbon bond, or an addition salt with a pharmaceutically acceptable acid.

    摘要翻译： 一种向需要神经保护的患者提供神经保护的方法，包括给予神经保护有效量的其中X为氧原子或= N-OH基团的式I化合物，R选自A 是氢原子或与B一起形成碳 - 碳键，B为氢原子，羟基或与A为碳 - 碳键，C为氢原子，或与D为碳 - 碳键，D为 氢原子或与碳碳键一起，E为氢原子，或与F为碳 - 碳键，F为氢原子，或与碳为碳原子一起形成，或与药物上的加成盐 可接受的酸。

    Novel Derivatives of 3.5-Seco-4-Norcholestane and Use Thereof
    4.
    发明申请
    Novel Derivatives of 3.5-Seco-4-Norcholestane and Use Thereof 有权
    3.5-Seco-4-Norcholestane的新型衍生物及其用途

    公开(公告)号：US20080275130A1

    公开(公告)日：2008-11-06

    申请号：US11662088

    申请日：2005-08-19

    申请人： Thierry Bordet ,  Cyrille Drouot

    发明人： Thierry Bordet ,  Cyrille Drouot

    IPC分类号： A61K31/15 ,  C07C251/42 ,  A61P25/00

    CPC分类号： C07C251/44 ,  C07C2603/12

    摘要： The invention relates to compounds of formula (I): where X+Y=keto, or X=OH and Y=H, or X+Y=oxime or methyloxime, B=OH and C+D=H, or C+D=C1-C4 linear or branched alkyl, or C=H and D=C1-C4 linear or branched alkyl, or B+C=keto and D=methyl, hydroxyl, or methylamino, or B and C=H and D=methylamino, or B+C=oxime and D=methyl and R=C1-C10 linear or branched alkyl, the salts, esters, or salts of esters thereof as medicament, in particular as neuroprotectors, novel compounds of formula (I) and pharmaceutical compositions.

    摘要翻译： 本发明涉及式（I）化合物：其中X + Y =酮基，或X = OH和Y = H，或X + Y =肟或甲基肟，B = OH和C + D = H或C + D 或C = H和D = C 1 -C 4直链或支链烷基，或B + C =酮基，D =甲基，羟基或甲基氨基，或B和C = H和D =甲基氨基 ，或B + C =肟和D =甲基，R = C 1 -C 10直链或支链烷基，其酯，酯或其盐作为药物，特别是作为神经保护剂，新的式（I）化合物和药物组合物 。

    Derivatives of 3.5-seco-4-norcholestane and use thereof
    5.
    发明授权
    Derivatives of 3.5-seco-4-norcholestane and use thereof 有权
    3.5-seco-4-norcholestane的衍生物及其用途

    公开(公告)号：US09045393B2

    公开(公告)日：2015-06-02

    申请号：US11662088

    申请日：2005-08-19

    申请人： Thierry Bordet ,  Cyrille Drouot

    发明人： Thierry Bordet ,  Cyrille Drouot

    IPC分类号： A61K31/15 ,  C07C251/44

    CPC分类号： C07C251/44 ,  C07C2603/12

    摘要： The invention relates to compounds of formula (I): where X+Y=keto, or X=OH and Y=H, or X+Y=oxime or methyloxime, B=OH and C+D=H, or C+D=C1-C4 linear or branched alkyl, or C=H and D=C1-C4 linear or branched alkyl, or B+C=keto and D=methyl, hydroxyl, or methylamino, or B and C=H and D=methylamino, or B+C=oxime and D=methyl and R=C1-C10 linear or branched alkyl, the salts, esters, or salts of esters thereof as medicament, in particular as neuroprotectors, novel compounds of formula (I) and pharmaceutical compositions.

    摘要翻译： 本发明涉及式（I）化合物：其中X + Y =酮基，或X = OH和Y = H，或X + Y =肟或甲基肟，B = OH和C + D = H或C + D 或C = H和D = C 1 -C 4直链或支链烷基，或B + C =酮基，D =甲基，羟基或甲基氨基，或B和C = H和D =甲基氨基 ，或B + C =肟和D =甲基，R = C 1 -C 10直链或支链烷基，其酯，酯或其盐作为药物，特别是作为神经保护剂，新的式（I）化合物和药物组合物 。

    Method for providing neuroprotection
    6.
    发明授权
    Method for providing neuroprotection 有权
    提供神经保护的方法

    公开(公告)号：US08575138B2

    公开(公告)日：2013-11-05

    申请号：US13591774

    申请日：2012-08-22

    申请人： Thierry Bordet ,  Cyrille Drouot ,  Bruno Buisson

    发明人： Thierry Bordet ,  Cyrille Drouot ,  Bruno Buisson

    IPC分类号： A61K31/575 ,  A61P35/00 ,  A61P25/00

    CPC分类号： C07J9/00 ,  A61K31/575

    摘要： A method for providing neuroprotection to a patient in need of neuroprotection, comprising administering a neuroprotective-effective amount of a compound of formula I in which X is an oxygen atom or an ═N—OH group, R is selected from the group consisting of A is a hydrogen atom or together with B a carbon-carbon bond, B is a hydrogen atom, a hydroxy group or together with A a carbon-carbon bond, C is a hydrogen atom or together with D a carbon-carbon bond, D is a hydrogen atom or together with C a carbon-carbon bond, E is a hydrogen atom or together with F a carbon-carbon bond, F is a hydrogen atom or together with E a carbon-carbon bond, or an addition salt with a pharmaceutically acceptable acid.

    摘要翻译： 一种向需要神经保护的患者提供神经保护作用的方法，包括给予神经保护有效量的其中X为氧原子或= N-OH基团的式I化合物，R选自A 是氢原子或与B一起形成碳 - 碳键，B为氢原子，羟基或与A为碳 - 碳键，C为氢原子，或与D为碳 - 碳键，D为 氢原子或与碳碳键一起，E为氢原子，或与F为碳 - 碳键，F为氢原子，或与碳为碳原子一起形成，或与药物上的加成盐 可接受的酸。

    METHOD FOR PROVIDING NEUROPROTECTION
    7.
    发明申请
    METHOD FOR PROVIDING NEUROPROTECTION 有权
    提供神经保护的方法

    公开(公告)号：US20120309721A1

    公开(公告)日：2012-12-06

    申请号：US13591774

    申请日：2012-08-22

    申请人： Thierry Bordet ,  Cyrille Drouot ,  Bruno Buisson

    发明人： Thierry Bordet ,  Cyrille Drouot ,  Bruno Buisson

    IPC分类号： A61K31/575 ,  A61P35/00 ,  A61P25/00

    CPC分类号： C07J9/00 ,  A61K31/575

    摘要： A method for providing neuroprotection to a patient in need of neuroprotection, comprising administering a neuroprotective-effective amount of a compound of formula I in which X is an oxygen atom or an =N—OH group,R is selected from the group consisting of A is a hydrogen atom or together with B a carbon-carbon bond,B is a hydrogen atom, a hydroxy group or together with A a carbon-carbon bond,C is a hydrogen atom or together with D a carbon-carbon bond,D is a hydrogen atom or together with C a carbon-carbon bond,E is a hydrogen atom or together with F a carbon-carbon bond,F is a hydrogen atom or together with E a carbon-carbon bond, or an addition salt with a pharmaceutically acceptable acid.

    摘要翻译： 一种向需要神经保护的患者提供神经保护作用的方法，包括给予神经保护有效量的其中X为氧原子或= N-OH基团的式I化合物，R选自A 是氢原子或与B一起形成碳 - 碳键，B为氢原子，羟基或与A为碳 - 碳键，C为氢原子，或与D为碳 - 碳键，D为 氢原子或与碳碳键一起，E为氢原子，或与F为碳 - 碳键，F为氢原子，或与碳为碳原子一起形成，或与药物上的加成盐 可接受的酸。

    Use of derivatives of cholest-4-en-3-one as medicaments, pharmaceutical compositions containing same, novel derivatives and preparation method thereof
    8.
    发明授权
    Use of derivatives of cholest-4-en-3-one as medicaments, pharmaceutical compositions containing same, novel derivatives and preparation method thereof 有权
    胆甾-4-烯-3-酮衍生物作为药物的用途，含有它们的药物组合物，新型衍生物及其制备方法

    公开(公告)号：US07858603B2

    公开(公告)日：2010-12-28

    申请号：US10548473

    申请日：2004-03-05

    申请人： Thierry Bordet ,  Cyrille Drouot ,  Bruno Buisson

    发明人： Thierry Bordet ,  Cyrille Drouot ,  Bruno Buisson

    IPC分类号： A61K31/575 ,  C07J9/00 ,  C07J41/00

    CPC分类号： C07J9/00 ,  A61K31/575

    摘要： Compound of formula I where X=O or ═N—OH group, R represents a group chosen from A=hydrogen or together with B a carbon-carbon bond, B=hydrogen, hydroxy or together with A a carbon-carbon bond, C, D, E, F=hydrogen or together with D a carbon-carbon bond, or the one of its addition salts with pharmaceutically acceptable acids, with the exception of a few compounds, as a medicament, use in particular as neuroprotectors, novel compounds of formula I and pharmaceutical compositions.

    摘要翻译： 式I的化合物，其中X = O或= N-OH基团，R表示选自A =氢或与B一起形成碳 - 碳键的基团，B =氢，羟基或与碳碳键连接，C ，D，E，F =氢或与D一个碳 - 碳键，或其加成盐与药学上可接受的酸之一，除少数化合物外，作为药物，尤其用作神经保护剂，新化合物 的式I和药物组合物。

    USE AS MEDICAMENTS OF DERIVATIVES OF CHOLEST-4-EN-3-ONE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, NOVEL DERIVATIVES AND THEIR PREPARATION PROCESS
    9.
    发明申请
    USE AS MEDICAMENTS OF DERIVATIVES OF CHOLEST-4-EN-3-ONE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, NOVEL DERIVATIVES AND THEIR PREPARATION PROCESS 有权
    用作美洛昔康4-EN-3-ONE衍生物的药物，含有它们的药物组合物，新型衍生物及其制备方法

    公开(公告)号：US20100216752A1

    公开(公告)日：2010-08-26

    申请号：US12776217

    申请日：2010-05-07

    申请人： Thierry BORDET ,  Cyrille Drouot ,  Bruno Buisson

    发明人： Thierry BORDET ,  Cyrille Drouot ,  Bruno Buisson

    IPC分类号： A61K31/565 ,  A61P25/02 ,  A61P25/08 ,  A61P25/22 ,  A61P25/24

    CPC分类号： C07J9/00 ,  A61K31/575

    摘要： A method for providing neuroprotection to a patient in need of neuroprotection, comprising administering a neuroprotective-effective amount of a compound of formula I in which X is an oxygen atom or an ═N—OH group, R is selected from the group consisting of A is a hydrogen atom or together with B a carbon-carbon bond, B is a hydrogen atom, a hydroxy group or together with A a carbon-carbon bond, C is a hydrogen atom or together with D a carbon-carbon bond, D is a hydrogen atom or together with C a carbon-carbon bond, E is a hydrogen atom or together with F a carbon-carbon bond, F is a hydrogen atom or together with E a carbon-carbon bond, or an addition salt with a pharmaceutically acceptable acid.

    摘要翻译： 一种向需要神经保护的患者提供神经保护的方法，包括给予神经保护有效量的其中X为氧原子或= N-OH基团的式I化合物，R选自A 是氢原子或与B一起形成碳 - 碳键，B为氢原子，羟基或与A为碳 - 碳键，C为氢原子，或与D为碳 - 碳键，D为 氢原子或与碳碳键一起，E为氢原子，或与F为碳 - 碳键，F为氢原子，或与碳为碳原子一起形成，或与药物上的加成盐 可接受的酸。

    Chemical compounds and the uses thereof as a medicine
    10.
    发明授权
    Chemical compounds and the uses thereof as a medicine 失效
    化合物及其作为药物的用途

    公开(公告)号：US08691854B2

    公开(公告)日：2014-04-08

    申请号：US11994354

    申请日：2006-06-29

    申请人： Corinne Chaimbault ,  Cyrille Drouot ,  Laure Jamot ,  Rebecca Pruss ,  Céline Simon

    发明人： Corinne Chaimbault ,  Cyrille Drouot ,  Laure Jamot ,  Rebecca Pruss ,  Céline Simon

    IPC分类号： A01N43/78 ,  A61K31/425 ,  C07D277/00 ,  C07D327/04 ,  C07D343/00

    CPC分类号： C07D277/50

    摘要： The present invention relates to the field of pharmacy, especially the treatment of neurodegenerative diseases. The invention specifically relates to a family of chemical compounds for which a neuroprotective activity has been demonstrated.Given that certain members of said family are novel compounds which have never been described, the invention relates to said novel products, the synthesis method thereof and certain novel intermediate synthesis products.The present invention further relates to compositions comprising the compounds of said family, and the use of said compounds as medicaments, especially for the preparation of a medicament for the treatment of neurodegenerative diseases.

    摘要翻译： 本发明涉及药学领域，特别是治疗神经变性疾病。 本发明具体涉及已经证明了神经保护活性的化合物族。 鉴于所述家族的某些成员是未经描述的新化合物，本发明涉及所述新产品，其合成方法和某些新型中间体合成产品。 本发明还涉及包含所述家族化合物的组合物和所述化合物作为药物的用途，特别是用于制备用于治疗神经变性疾病的药物。