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1.发明授权
公开(公告)号：US3962436A
公开(公告)日：1976-06-08
申请号：US499572
申请日：1974-08-22
IPC分类号： A61K9/48 , A61K31/525 , A61K47/18 , A61K47/26 , A61K31/615 , A61K31/635 , A61K47/00
CPC分类号： A61K31/70 , A61K31/525 , A61K47/18 , A61K47/26 , A61K9/4858
摘要： Pharmaceutical compositions with controlled rates of gastro-intestinal absorption are prepared by dissolution or suspension of the therapeutically active agent in an absorption depressive agent selected from the group consisting of unsaturated aliphatic alcohols or their esters, unsaturated aliphatic ethers, unsaturated aliphatic acids or their salts, their esters or their amides and natural occurring oils containing more than 35% by weight of any of the above-mentioned substances, said absorption depressive materials having 12 - 22 carbon atoms in their unsaturated aliphatic hydrocarbon chains and being liquid at the normal temperature.
摘要翻译： 通过将治疗活性剂溶解或悬浮在选自不饱和脂族醇或其酯，不饱和脂族醚，不饱和脂族酸或其盐的吸收抑制剂中来制备具有受胃肠吸收控制率的药物组合物， 它们的酯或其酰胺和含有超过35重量％的任何上述物质的天然存在的油，所述吸收抑制材料在其不饱和脂族烃链中具有12-22个碳原子，并且在常温下为液体。
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公开(公告)号：US4226769A
公开(公告)日：1980-10-07
申请号：US961841
申请日：1978-11-17
申请人： Terutsugu Tsuji , Shigeji Sato , Keiji Fujioka , Yoshiya Yamahira , Tadao Maeda
发明人： Terutsugu Tsuji , Shigeji Sato , Keiji Fujioka , Yoshiya Yamahira , Tadao Maeda
IPC分类号： C07D519/06 , A61K9/14 , A61K9/19 , C07D499/00 , C07D499/18 , C07D499/68
CPC分类号： C07D499/00
摘要： A process for freeze-drying a penicillin derivative of the formula: ##STR1## wherein R is a hydrogen atom or a hydroxyl group, by evaporating a frozen aqueous solution of the penicillin derivative (I) under vacuum from the frozen state to dryness, which is characterized by maintaining the temperature of the frozen solution within a range from the eutectic point of the solution determined by the electric resistance method to -8.degree. C. when the penicillin derivative of the formula (I) wherein R is a hydrogen atom is to be freeze-dried, or -10.degree. C. when the penicillin derivative of the formula (I) wherein R is a hydroxyl group is to be freeze-dried during the primary drying period of the drying process.
摘要翻译： 一种冷冻干燥下式的青霉素衍生物的方法：其中R是氢原子或羟基，其中R是氢原子或羟基，在冷冻状态下将青霉素衍生物（I）的真空冷冻水溶液蒸发至 干燥，其特征在于当式（I）的青霉素衍生物其中R为氢时，将冷冻溶液的温度保持在由电阻法测定的溶液的共晶点至-8℃的范围内 当干燥过程的一次干燥期间，当其中R为羟基的式（I）的青霉素衍生物在干燥过程的一级干燥期间被冷冻干燥时，原子将被冷冻干燥或-10℃。
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公开(公告)号：US20130072558A1
公开(公告)日：2013-03-21
申请号：US13620051
申请日：2012-09-14
IPC分类号： A61K31/22 , A61K31/225
CPC分类号： A61K31/215 , A61K9/0053 , A61K31/07 , A61K31/22 , A61K31/4709 , Y10S514/912
摘要： A method of treating or preventing age-related retinal dysfunction involves administering to a patient a pharmaceutically effective amount of a synthetic retinal derivative repeatedly over a duration of at least about 3 months. Effective synthetic retinal derivatives include 9-cis-retinyl esters, 11-cis-retinyl esters, derivatives and congeners thereof, and combinations thereof. Suitable ester substituents include carboxylates of C1-C10 monocarboxylic acids and C2-C22 polycarboxylic acids.
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4.发明授权公开(公告)号：US09233091B2
公开(公告)日：2016-01-12
申请号：US13620303
申请日：2012-09-14
IPC分类号： A61K31/4709 , A61K31/215 , A61K31/07 , A61K31/22
CPC分类号： A61K31/215 , A61K9/0053 , A61K31/07 , A61K31/22 , A61K31/4709 , Y10S514/912
摘要： A method of treating or preventing age-related retinal dysfunction involves administering to a patient a pharmaceutically effective amount of a synthetic retinal derivative repeatedly over a duration of at least about 3 months. Effective synthetic retinal derivatives include 9-cis-retinyl esters, 11-cis-retinyl esters, derivatives and congeners thereof, and combinations thereof. Suitable ester substituents include carboxylates of C1-C10 monocarboxylic acids and C2-C22 polycarboxylic acids.
摘要翻译： 治疗或预防年龄相关性视网膜功能障碍的方法包括在至少约3个月的持续时间内重复给患者药物有效量的合成的视黄醛衍生物。 有效的合成视黄醛衍生物包括9-顺 - 视黄酯，11-顺 - 视黄酯，其衍生物和同系物及其组合。 合适的酯取代基包括C1-C10单羧酸和C2-C22多元羧酸的羧酸盐。
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公开(公告)号：US09408821B2
公开(公告)日：2016-08-09
申请号：US13619947
申请日：2012-09-14
IPC分类号： A61K31/215 , A61K31/4709 , A61K31/07 , A61K31/22
CPC分类号： A61K31/215 , A61K9/0053 , A61K31/07 , A61K31/22 , A61K31/4709 , Y10S514/912
摘要： A method of treating or preventing age-related retinal dysfunction involves administering to a patient a pharmaceutically effective amount of a synthetic retinal derivative repeatedly over a duration of at least about 3 months. Effective synthetic retinal derivatives include 9-cis-retinyl esters, 11-cis-retinyl esters, derivatives and congeners thereof, and combinations thereof. Suitable ester substituents include carboxylates of C1-C10 monocarboxylic acids and C2-C22 polycarboxylic acids.
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6.发明授权公开(公告)号：US08324270B2
公开(公告)日：2012-12-04
申请号：US12368427
申请日：2009-02-10
IPC分类号： A61K31/215 , A61K31/21
CPC分类号： A61K31/215 , A61K9/0053 , A61K31/07 , A61K31/22 , A61K31/4709 , Y10S514/912
摘要： A method of treating or preventing age-related retinal dysfunction involves administering to a patient a pharmaceutically effective amount of a synthetic retinal derivative repeatedly over a duration of at least about 3 months. Effective synthetic retinal derivatives include 9-cis-retinyl esters, 11-cis-retinyl esters, derivatives and congeners thereof, and combinations thereof. Suitable ester substituents include carboxylates of C1-C10 monocarboxylic acids and C2-C22 polycarboxylic acids.
摘要翻译： 治疗或预防年龄相关性视网膜功能障碍的方法包括在至少约3个月的持续时间内重复给患者药物有效量的合成的视黄醛衍生物。 有效的合成视黄醛衍生物包括9-顺 - 视黄酯，11-顺 - 视黄酯，其衍生物和同系物及其组合。 合适的酯取代基包括C1-C10单羧酸和C2-C22多元羧酸的羧酸盐。
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7.发明申请METHODS FOR THE TREATMENT AND PREVENTION OF AGE-RELATED RETINAL DYSFUNCTION 有权用于治疗和预防与年龄相关的肾功能衰竭的方法公开(公告)号：US20130072557A1
公开(公告)日：2013-03-21
申请号：US13619947
申请日：2012-09-14
IPC分类号： A61K31/215
CPC分类号： A61K31/215 , A61K9/0053 , A61K31/07 , A61K31/22 , A61K31/4709 , Y10S514/912
摘要： A method of treating or preventing age-related retinal dysfunction involves administering to a patient a pharmaceutically effective amount of a synthetic retinal derivative repeatedly over a duration of at least about 3 months. Effective synthetic retinal derivatives include 9-cis-retinyl esters, 11-cis-retinyl esters, derivatives and congeners thereof, and combinations thereof. Suitable ester substituents include carboxylates of C1-C10 monocarboxylic acids and C2-C22 polycarboxylic acids.
摘要翻译： 治疗或预防年龄相关性视网膜功能障碍的方法包括在至少约3个月的持续时间内重复给患者药物有效量的合成的视黄醛衍生物。 有效的合成视黄醛衍生物包括9-顺 - 视黄酯，11-顺 - 视黄酯，其衍生物和同系物及其组合。 合适的酯取代基包括C1-C10单羧酸和C2-C22多元羧酸的羧酸盐。
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8.发明申请METHODS FOR THE TREATMENT AND PREVENTION OF AGE-RELATED RETINAL DYSFUNCTION 有权用于治疗和预防与年龄相关的肾功能衰竭的方法公开(公告)号：US20130072561A1
公开(公告)日：2013-03-21
申请号：US13620303
申请日：2012-09-14
IPC分类号： A61K31/22 , A61K31/225
CPC分类号： A61K31/215 , A61K9/0053 , A61K31/07 , A61K31/22 , A61K31/4709 , Y10S514/912
摘要： A method of treating or preventing age-related retinal dysfunction involves administering to a patient a pharmaceutically effective amount of a synthetic retinal derivative repeatedly over a duration of at least about 3 months. Effective synthetic retinal derivatives include 9-cis-retinyl esters, 11-cis-retinyl esters, derivatives and congeners thereof, and combinations thereof. Suitable ester substituents include carboxyiates of C1-C10 monocarboxylic acids and C2-C22 polycarboxylic acids.
摘要翻译： 治疗或预防年龄相关性视网膜功能障碍的方法包括在至少约3个月的持续时间内重复给患者药物有效量的合成的视黄醛衍生物。 有效的合成视黄醛衍生物包括9-顺 - 视黄酯，11-顺 - 视黄酯，其衍生物和同系物及其组合。 合适的酯取代基包括C1-C10一元羧酸和C2-C22多元羧酸的羧酸酯。
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9.发明申请METHODS FOR THE TREATMENT AND PREVENTION OF AGE-RELATED RETINAL DYSFUNCTION 有权用于治疗和预防与年龄相关的肾功能衰竭的方法公开(公告)号：US20100035986A1
公开(公告)日：2010-02-11
申请号：US12368427
申请日：2009-02-10
IPC分类号： A61K31/215 , A61K31/11 , A61P27/02
CPC分类号： A61K31/215 , A61K9/0053 , A61K31/07 , A61K31/22 , A61K31/4709 , Y10S514/912
摘要： A method of treating or preventing age-related retinal dysfunction involves administering to a patient a pharmaceutically effective amount of a synthetic retinal derivative repeatedly over a duration of at least about 3 months. Effective synthetic retinal derivatives include 9-cis-retinyl esters, 11-cis-retinyl esters, derivatives and congeners thereof, and combinations thereof. Suitable ester substituents include carboxylates of C1-C10 monocarboxylic acids and C2-C22 polycarboxylic acids.
摘要翻译： 治疗或预防年龄相关性视网膜功能障碍的方法包括在至少约3个月的持续时间内重复给患者药物有效量的合成的视黄醛衍生物。 有效的合成视黄醛衍生物包括9-顺 - 视黄酯，11-顺 - 视黄酯，其衍生物和同系物及其组合。 合适的酯取代基包括C1-C10单羧酸和C2-C22多元羧酸的羧酸盐。
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