公开(公告)号：US20190322986A1

公开(公告)日：2019-10-24

申请号：US15977505

申请日：2018-05-11

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Gordon Keller ,  April M. Craft ,  Nicole C. Dubois

IPC: C12N5/077 ,  C12Q1/6881

Abstract: The present invention relates to in vitro methods of enriching populations of human pluripotent stem cells that are induced to differentiate to cardiomyocyte progenitor cells and cardiomyocyte cells. The cell populations can be enriched by isolating cells that express SIRPA. The invention also related to in vitro-enriched populations of cardiomyocyte cells and cardiomyocyte progenitor cells obtained from populations of pluripotent stem.

公开(公告)号：US20200239848A1

公开(公告)日：2020-07-30

申请号：US16847597

申请日：2020-04-13

Applicant: University Health Network

Inventor： Gordon Keller ,  April M. Craft ,  Nicole C. Dubois

IPC: C12N5/077 ,  C12Q1/6881 ,  G01N33/569 ,  G01N33/50 ,  G01N33/53

Abstract: The present invention relates to in vitro methods of enriching populations of human pluripotent stem cells that are induced to differentiate to cardiomyocyte progenitor cells and cardiomyocyte cells. The cell populations can be enriched by isolating cells that express SIRPA. The invention also related to in vitro-enriched populations of cardiomyocyte cells and cardiomyocyte progenitor cells obtained from populations of pluripotent stem.