公开(公告)号：US20250069224A1

公开(公告)日：2025-02-27

申请号：US18943247

申请日：2024-11-11

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Ralph S. DaCosta ,  Danielle Dunham

IPC: G06T7/00 ,  A61B5/00 ,  G06T7/33 ,  G16H30/40

Abstract: The present disclosure provides methods, systems, and devices for coregistering imaging data to form three-dimensional superimposed images of a biological target such as a wound, a tumor, or a surgical bed. A three-dimensional map can be generated by projecting infrared radiation at a target area, receiving reflected infrared radiation, and measuring depth of the target area. A three-dimensional white light image can be created from a captured two-dimensional white light image and the three-dimensional map. A three-dimensional fluorescence image can be created from a captured two-dimensional fluorescence image and the three-dimensional map. The three-dimensional white light image and the three-dimensional fluorescence image can be aligned using one or more fiducial markers to form a three-dimensional superimposed image. The superimposed image can be used to track wound healing and to excise cancerous tissues, for example, breast tumors. Images can be in the form of videos.

公开(公告)号：US12207651B2

公开(公告)日：2025-01-28

申请号：US16500657

申请日：2018-03-29

Applicant: University Health Network ,  Universidade de São Paulo

Inventor： Vanderlei Salvador Bagnato ,  Marcelo Cypel ,  Shafique Keshavjee ,  Thomas Kenneth Waddell ,  Marcos Theophilo Galasso

IPC: A01N1/02 ,  A61B17/00 ,  A61L2/00 ,  A61L2/10 ,  A61L2/24 ,  A61L2/26

Abstract: Disclosed are apparatuses and methods for irradiating a perfusate. The apparatus includes a tank which defines a first chamber. A separator is located inside the first chamber. The separator defines a second chamber. The first chamber and the second chamber are concentric and have substantially annular cross sections, each having at least one diameter and a substantially common longitudinal axis. A perfusate is introduced into the first chamber by an inlet. A UV radiation-emitting device is disposed inside the second chamber for providing irradiation to the perfusate. Irradiated perfusate is removed from the tank by an outlet. Other apparatuses and systems are described and methods for inactivating micro organisms by performing EVP and irradiating the perfusate.

公开(公告)号：US20240398869A1

公开(公告)日：2024-12-05

申请号：US18526459

申请日：2023-12-01

Applicant: University Health Network

Inventor： Gordon Keller ,  Stephanie Protze ,  Jee Hoon Lee

IPC: A61K35/28 ,  A61K35/34 ,  A61P9/04 ,  C12N5/077 ,  G01N33/50 ,  G01N33/68

Abstract: Methods are disclosed for producing populations of cardiomyocytes from pluripotent stem cells. Populations may be enriched for either atrial or ventricular cardiomyocytes and the resulting ventricular population may be essentially free of pacemaker cells. The method includes incubating pluripotent stem cells in a suitable medium with a BMP component, and an activin component, the amounts of activin may be varied to enrich for either atrial or ventricular cardiomyocytes. The enriched populations, as well as methods of using the same to treat patients in need of cardiac repair are disclosed.

公开(公告)号：US12141964B2

公开(公告)日：2024-11-12

申请号：US17423449

申请日：2020-01-17

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Ralph S. DaCosta ,  Danielle Dunham

IPC: G06T7/00 ,  A61B5/00 ,  G06T7/33 ,  G16H30/40

Abstract: The present disclosure provides methods, systems, and devices for coregistering imaging data to form three-dimensional superimposed images of a biological target such as a wound, a tumor, or a surgical bed. A three-dimensional map can be generated by projecting infrared radiation at a target area, receiving reflected infrared radiation, and measuring depth of the target area. A three-dimensional white light image can be created from a captured two-dimensional white light image and the three-dimensional map. A three-dimensional fluorescence image can be created from a captured two-dimensional fluorescence image and the three-dimensional map. The three-dimensional white light image and the three-dimensional fluorescence image can be aligned using one or more fiducial markers to form a three-dimensional superimposed image. The superimposed image can be used to track wound healing and to excise cancerous tissues, for example, breast tumors. Images can be in the form of videos.

公开(公告)号：US20240307308A1

公开(公告)日：2024-09-19

申请号：US18578888

申请日：2022-07-12

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Gang ZHENG ,  Juan CHEN ,  Tiffany Thanh-Uyen HO ,  Jiachuan BU ,  Lili DING

IPC: A61K9/127 ,  A61K41/00 ,  A61K51/04 ,  A61K51/12

CPC classification number: A61K9/1272 ,  A61K41/0071 ,  A61K51/0497 ,  A61K51/1234

Abstract: There is described herein a bilayer nanovesicle comprising porphyrin-phospholipid conjugate and a chelator-fatty acid conjugate; wherein the chelator-fatty acid conjugate comprises an aminopolycarboxylic acid conjugated to a single chain fatty acid; and the porphyrin-phospholipid conjugate comprises one porphyrin, porphyrin derivative or porphyrin analog covalently attached to a lipid side chain, preferably at the sn-1 or the sn-2 position, of one phospholipid.

公开(公告)号：US20240251783A1

公开(公告)日：2024-08-01

申请号：US18565387

申请日：2022-03-08

Applicant: University Health Network

Inventor： Mingyao Liu ,  Shafique Keshavjee ,  Marcelo Cypel

IPC: A01N1/02

CPC classification number: A01N1/0226 ,  A01N1/0284

Abstract: Provided is a lung preservation composition comprising a non-carbonic buffered nutrient media, preferably a phosphate buffered nutrient media, and a dextran, optionally Dextran 40 and and optionally prostaglandin E1 (PGE1), and optionally at least one of alpha 1 antitrypsin (A1AT), an impermeant, optionally raffinose, an antioxidant, optionally glutathione, and necrostatin-1. Also described is a method of preserving a lung prior to and/or during transplant using said lung preservation composition, and kits comprising one or more components of the lung preservation composition.

公开(公告)号：US20240241136A1

公开(公告)日：2024-07-18

申请号：US18537455

申请日：2023-12-12

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Ivan MARTINEZ-VALBUENA ,  Gabor G. KOVACS ,  Anthony E. LANG

IPC: G01N33/68

CPC classification number: G01N33/6896 ,  G01N2333/4728 ,  G01N2800/2835

Abstract: In an aspect, there is provided a method for differentiating movement disorders in a subject, comprising performing a seeding amplification assay for alpha-synuclein in a subject sample utilizing a specific buffer conditions, measuring the alpha-synuclein aggregation of the sample in the assay based on at least one of the following kinetic parameters: lag time, growth phase, T50, ThT max and AUC; and differentiating between Parkinson's Disease (PD) and Multiple System Atrophy (MSA) based on said sample kinetic parameters compared to control kinetic parameters, wherein control kinetic parameters for MSA show at least a two-fold difference from the control kinetic parameters for PD.

公开(公告)号：US20240180922A1

公开(公告)日：2024-06-06

申请号：US18437093

申请日：2024-02-08

Applicant: University of Manitoba ,  University Health Network ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Paul Fernyhough ,  Nigel A. Calcutt ,  Lakshmi Kotra

IPC: A61K31/5513 ,  A61K31/46 ,  A61K31/496 ,  A61K31/5517 ,  C07D417/12

CPC classification number: A61K31/5513 ,  A61K31/46 ,  A61K31/496 ,  A61K31/5517 ,  C07D417/12

Abstract: Treatments for therapy of a diabetic symmetrical polyneuropathy a subject in need thereof. The treatments includes administration of compositions comprising: an effective amount of a muscarinic acetylcholine receptor antagonist exemplified by pirenzepine, telenzepine, atropine, or derivatives thereof or salts thereof or analogs thereof or derivatives thereof, and a pharmacologically acceptable carrier. The composition may be injectable or alternatively, may be applied topically or alternatively, may be delivered orally. A suitable topical composition may comprise a lotion, a cream, a gel, or a viscous fluid. The muscarinic acetylcholine receptor antagonist may be a muscarinic acetylcholine receptor antagonist salt or a muscarinic acetylcholine receptor antagonist derivative or a muscarinic acetylcholine receptor antagonist analog.

公开(公告)号：US11977027B2

公开(公告)日：2024-05-07

申请号：US18202823

申请日：2023-05-26

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE ,  UNIVERSITY HEALTH NETWORK

Inventor： Keith D. Paulsen ,  David W. Roberts ,  Dennis Wirth ,  Brian C. Wilson ,  Mira Sibai

IPC: G01B11/22 ,  G01N21/47 ,  G01N21/64 ,  G01N33/483

CPC classification number: G01N21/6456 ,  G01B11/22 ,  G01N21/4795 ,  G01N33/4833 ,  G01N2201/062

Abstract: A method and device for determining the depth and fluorophore concentration of a fluorophore concentration below the surface of an optically absorbing and scattering medium suitable for use in fluorescence-based surgical guidance such as in tumor resection is described. Long-wavelength stimulus light us used to obtain deep tissue penetration. Recovery of depth is performed by fitting measured modulation amplitudes for each spatial frequency to precomputed modulation amplitudes in a table of modulation amplitudes indexed by optical parameters and depth.

公开(公告)号：US20240084399A1

公开(公告)日：2024-03-14

申请号：US18518353

申请日：2023-11-22

Applicant: UNIVERSITY HEALTH NETWORK ,  THE HOSPITAL FOR SICK CHILDREN

Inventor： Jean C.Y. WANG ,  John DICK ,  Jayne DANSKA ,  Liqing JIN ,  Alexandre THEOCHARIDES ,  Sujeetha RAJAKUMAR

IPC: C12Q1/6886 ,  A61K38/16

CPC classification number: C12Q1/6886 ,  A61K38/16 ,  C12Q2600/156

Abstract: The invention relates to modulating the SIRPα-CD47 interaction in order to treat hematological cancer and compounds therefor. In some embodiments, there is provided methods and uses of SIRPα polypeptides, fragments and fusion proteins for treating hematological cancer, preferably human acute myeloid leukemia.