公开(公告)号：US20210069316A1

公开(公告)日：2021-03-11

申请号：US16772348

申请日：2018-12-11

Applicant: UNIVERSITY OF MANITOBA

Inventor： Xiaojian Yao ,  Zhujun Ao ,  Gary Kobinger

IPC: A61K39/12 ,  A61K39/385 ,  C12N15/62 ,  C07K14/005

Abstract: We have developed a series of Ebola vims envelope glycoprotein (EboGP)-based chimeric fusion proteins that are still able to maintain an efficient EboGP-mediated virus entry in various cell types including human antigen-presenting cells (APCs) while presenting large viral polypeptides, such as HIV Env v3-v5 domain (as large as 241 aa), at the apex and the sides of each EboGP monomer to elicit robust host immune responses. This invention demonstrates the feasibility of an EboGP-based chimeric fusion technology as a novel vaccine approach against different microbial pathogens, including that in human and animals, and against cancers.