公开(公告)号：US20160031929A1

公开(公告)日：2016-02-04

申请号：US14815686

申请日：2015-07-31

Applicant: University of Kansas

Inventor： Jeffrey Aube ,  Emily E. Scott ,  Charlie Fehl

IPC: C07J1/00 ,  C07D487/04 ,  C07D401/04 ,  C07J43/00 ,  C07J21/00

CPC classification number: C07D487/04 ,  C07D401/04 ,  C07J21/008 ,  C07J31/006 ,  C07J43/003 ,  C07J71/001 ,  C07J73/005

Abstract: Compounds according to formula I or II are provided. Such compounds are useful in treating cancers, such as leukemia, colon cancer, breast cancer, or prostate cancer by beneficially inhibiting CYP17A1. Pharmaceutical compositions and methods including the compounds are also provided.

Abstract translation: 提供了根据式I或II的化合物。 这些化合物通过有益地抑制CYP17A1可用于治疗癌症，如白血病，结肠癌，乳腺癌或前列腺癌。 还提供了包括该化合物的药物组合物和方法。

公开(公告)号：US09611270B2

公开(公告)日：2017-04-04

申请号：US14815686

申请日：2015-07-31

Applicant: University of Kansas

Inventor： Jeffrey Aube ,  Emily E. Scott ,  Charlie Fehl

IPC: C07D487/04 ,  C07J73/00 ,  C07J71/00 ,  C07J43/00 ,  C07D401/04 ,  C07J31/00 ,  C07J21/00

CPC classification number: C07D487/04 ,  C07D401/04 ,  C07J21/008 ,  C07J31/006 ,  C07J43/003 ,  C07J71/001 ,  C07J73/005

Abstract: Compounds according to formula I or II are provided. Such compounds are useful in treating cancers, such as leukemia, colon cancer, breast cancer, or prostate cancer by beneficially inhibiting CYP17A1. Pharmaceutical compositions and methods including the compounds are also provided.