公开(公告)号：US10059722B2

公开(公告)日：2018-08-28

申请号：US14439373

申请日：2013-11-04

申请人： University of Kansas ,  Cornell University

发明人： Jeffrey Aube ,  Carl Nathan ,  Robert Smith ,  Ben S. Gold ,  Paul Hanson ,  Chunjing Liu ,  Lester Allen Mitscher ,  Maneesh Pingle ,  Frank John Schoenen

IPC分类号： C07D501/60 ,  C07D501/16 ,  A61K31/545 ,  C07D499/44 ,  C07D277/06 ,  C07D417/12 ,  C07D513/04 ,  A61K45/06 ,  A61K31/426 ,  A61K31/427 ,  A61K31/429 ,  A61K31/43 ,  A61K31/431 ,  A61K31/4725 ,  A61K31/546

CPC分类号： C07D501/16 ,  A61K31/426 ,  A61K31/427 ,  A61K31/429 ,  A61K31/43 ,  A61K31/431 ,  A61K31/4725 ,  A61K31/545 ,  A61K31/546 ,  A61K45/06 ,  C07D277/06 ,  C07D417/12 ,  C07D499/44 ,  C07D513/04 ,  Y02A50/401 ,  Y02A50/402 ,  A61K2300/00

摘要： This invention provides cephalosporin derivatives for killing or inhibiting the spread of microorganisms such as non-replicating Mycobacterium tuberculosis and in the treatment of infectious disease.

公开(公告)号：US20170334889A1

公开(公告)日：2017-11-23

申请号：US15672574

申请日：2017-08-09

申请人： University of Kansas ,  The Regents of the University of Michigan ,  Wayne State University ,  Sanford-Burnham Medical Research Institute

发明人： Jennifer E. Golden ,  Jeffrey Aube ,  Daniel P. Flaherty ,  Andrew M. Fribley ,  Randal J. Kaufman ,  Thomas D.Y. Chung ,  Anthony B. Pinkerton ,  Michael Pablo Hedrick

IPC分类号： C07D405/12 ,  C07C303/36 ,  A61K45/06 ,  A61K31/5377 ,  A61K31/496 ,  C07D307/71 ,  A61K31/4525

摘要： N-substituted sulfonylphenyl-5-nitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provides as is their use in the treatment of diseases such as diabetes, Alzheimer's, Parkinson's, hemophilia, lysosomal storage diseases and cancer.

公开(公告)号：US09732067B2

公开(公告)日：2017-08-15

申请号：US14408736

申请日：2013-06-18

申请人： University of Kansas ,  The Regents of the University of Michigan ,  Wayne State University ,  Sanford-Burnham Medical Research Institute

发明人： Jennifer E. Golden ,  Jeffrey Aube ,  Daniel P. Flaherty ,  Andrew M. Fribley ,  Randal J. Kaufman ,  Thomas D. Y. Chung ,  Anthony B. Pinkerton ,  Michael Pablo Hedrick

IPC分类号： C07D405/12 ,  C07C303/36 ,  A61K31/4525 ,  C07D307/71 ,  A61K31/496 ,  A61K31/5377 ,  A61K45/06

CPC分类号： C07D405/12 ,  A61K31/4525 ,  A61K31/496 ,  A61K31/5377 ,  A61K45/06 ,  C07C303/36 ,  C07D307/71

摘要： N-substituted sulfonylphenyl-5-mitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provided as is their use in the treatment of diseases such as diabetes, Alzheimer's, Parkinson's, hemophilia, lysosomal storage diseases and cancer.

公开(公告)号：US20170166557A1

公开(公告)日：2017-06-15

申请号：US15443232

申请日：2017-02-27

申请人： University of Kansas ,  University of Louisville Research Foundation, Inc. ,  Southern Research Institute

发明人： Jennifer Golden ,  Jeffrey Aube ,  Donghoon Chung ,  Chad Schroeder ,  Tuanli Yao ,  E. Lucile White ,  Nichole A. Tower

IPC分类号： C07D409/04 ,  C07D403/12 ,  C07D239/95 ,  C07D403/06 ,  C07D401/04 ,  C07D239/91 ,  C07D239/90

CPC分类号： C07D409/04 ,  C07D239/90 ,  C07D239/91 ,  C07D239/95 ,  C07D241/06 ,  C07D401/04 ,  C07D403/06 ,  C07D403/12 ,  C07D409/12

摘要： The present technology relates to compounds and compositions of Formulas and methods using such compounds. The compounds and compositions described herein may be used in the treatment or prophylaxis of diseases associated with an alphavirus, for example, Venezuelan equine encephalitis virus (VEEV).

公开(公告)号：US10087168B2

公开(公告)日：2018-10-02

申请号：US15443232

申请日：2017-02-27

申请人： University of Kansas ,  University of Louisville Research Foundation, Inc. ,  Southern Research Institute

发明人： Jennifer Golden ,  Jeffrey Aube ,  Donghoon Chung ,  Chad Schroeder ,  Tuanli Yao ,  E. Lucile White ,  Nichole A. Tower

IPC分类号： C07D409/04 ,  C07D239/91 ,  C07D403/12 ,  C07D239/90 ,  C07D403/06 ,  C07D401/04 ,  C07D239/95

摘要： The present technology relates to compounds and compositions of Formulas I-III and methods using such compounds. The compounds and compositions described herein may be used in the treatment or prophylaxis of diseases associated with an alphavirus, for example, Venezuelan equine encephalitis virus (VEEV).

公开(公告)号：US09642835B2

公开(公告)日：2017-05-09

申请号：US13867658

申请日：2013-04-22

申请人： STC.UNM ,  University of Kansas

发明人： Angela Wandinger-Ness ,  Larry Sklar ,  Zurab Surviladze ,  Tudor Oprea ,  Laurie Hudson ,  Jeffrey Aube ,  Jennifer E. Golden ,  Chad E. Schroeder ,  Denise S. Simpson ,  Julica J. Noth

IPC分类号： A61K31/415 ,  A61K45/06 ,  C07D231/06 ,  A61K31/403 ,  A61K31/407

CPC分类号： A61K31/407 ,  A61K31/403 ,  A61K31/415 ,  A61K45/06 ,  C07D231/06 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/573 ,  Y02A50/473 ,  Y02A50/486 ,  A61K2300/00

摘要： The present invention relates to molecules which function as selective modulators (i.e., inhibitors and agonists, preferably inhibitors) of the Ras-homologous (Rho) family of small GTPases, in particular, Cdc42 GTPase and their use to treat diseases, for example cancers, including metastatic cancer, where Cdc42 GTPase is overexpressed or hyperactivated, genetic and acquired diseases where activation of Cdc42 GTPase plays a pivotal role (e.g., neurodegenerative diseases), rheumatoid arthritis, atherosclerosis, diabetes type I, autosomal polycystic kidney diease, cystic kidney disease, precystic kidney disease and microbial infections. Additionally, compounds according to the present invention may be used to inhibit rejection (graft host response) in transplant patients (pursuant to transplantation), to promote immunosuppression, anti-inflammatory response and to mobilize stem cell (migration) in patients in need, among others.

公开(公告)号：US20150329499A1

公开(公告)日：2015-11-19

申请号：US14651777

申请日：2013-12-13

申请人： UNIVERSITY OF KANSAS ,  UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. ,  SOUTHERN RESEARCH INSTITUTE

发明人： Jennifer Golden ,  Jeffrey Aube ,  Donghoon Chung ,  Chad Schroeder ,  Tuanli Yao ,  E. Lucile White ,  Nichole A. Tower

IPC分类号： C07D241/06

CPC分类号： C07D409/04 ,  C07D239/90 ,  C07D239/91 ,  C07D239/95 ,  C07D241/06 ,  C07D401/04 ,  C07D403/06 ,  C07D403/12 ,  C07D409/12

摘要： The present technology relates to compounds and compositions of Formulas I-III and methods using such compounds. The compounds and compositions described herein may be used in the treatment or prophylaxis of diseases associated with an alphavirus, for example, Venezuelan equine encephalitis virus (VEEV).

摘要翻译： 本技术涉及式I-III的化合物和组合物以及使用这些化合物的方法。 本文所述的化合物和组合物可用于治疗或预防与甲病毒属例如委内瑞兰马脑炎病毒（VEEV）相关的疾病。

公开(公告)号：US20150203477A1

公开(公告)日：2015-07-23

申请号：US14408736

申请日：2013-06-18

申请人： University of Kansas ,  The Regents of the University of Michigan ,  Wayne State University ,  Sanford-Burnham Medical Research Institute

发明人： Jennifer E. Golden ,  Jeffrey Aube ,  Daniel P. Flaherty ,  Andrew M. Fribley ,  Randal J. Kaufman ,  Thomas D.Y. Chung ,  Anthony B. Pinkerton ,  Michael Pablo Hedrick

IPC分类号： C07D405/12 ,  C07C303/36 ,  A61K45/06 ,  A61K31/5377 ,  A61K31/496 ,  C07D307/71 ,  A61K31/4525

CPC分类号： C07D405/12 ,  A61K31/4525 ,  A61K31/496 ,  A61K31/5377 ,  A61K45/06 ,  C07C303/36 ,  C07D307/71

摘要： N-substituted sulfonylphenyl-5-nitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provides as is their use in the treatment of diseases such as diabetes, Alzheimer's, Parkinson's, hemophilia, lysosomal storage diseases and cancer.

摘要翻译： N-取代的磺酰基苯基-5-硝基呋喃-2-甲酰胺衍生化合物，其选择性地激活未折叠蛋白质反应的凋亡但不适应臂，其用途可用于治疗疾病如糖尿病，阿尔茨海默氏症，帕金森病 ，血友病，溶酶体贮积病和癌症。

公开(公告)号：US10787439B2

公开(公告)日：2020-09-29

申请号：US15672574

申请日：2017-08-09

申请人： University of Kansas ,  The Regents of the University of Michigan ,  Wayne State University ,  Sanford-Burnham Medical Research Institute

发明人： Jennifer E. Golden ,  Jeffrey Aube ,  Daniel P. Flaherty ,  Andrew M. Fribley ,  Randal J. Kaufman ,  Thomas D. Y. Chung ,  Anthony B. Pinkerton ,  Michael Pablo Hedrick

IPC分类号： A61K31/4525 ,  C07D405/12 ,  C07D307/71 ,  A61K31/496 ,  A61K31/5377 ,  A61K45/06 ,  C07C303/36

摘要： N-substituted sulfonylphenyl-5-nitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provides as is their use in the treatment of diseases such as diabetes, Alzheimer's, Parkinson's, hemophilia, lysosomal storage diseases and cancer.

公开(公告)号：US10532999B2

公开(公告)日：2020-01-14

申请号：US16149009

申请日：2018-10-01

申请人： University of Kansas ,  University of Louisville Research Foundation, Inc. ,  Southern Research Institute

发明人： Jennifer Golden ,  Jeffrey Aube ,  Donghoon Chung ,  Chad Schroeder ,  Tuanli Yao ,  E. Lucile White ,  Nichole A. Tower

IPC分类号： C07D409/04 ,  C07D239/95 ,  C07D409/12 ,  C07D403/06 ,  C07D401/04 ,  C07D239/91 ,  C07D239/90 ,  C07D403/12 ,  C07D241/06

摘要： The present technology relates to compounds and compositions of Formulas I-III and methods using such compounds. The compounds and compositions described herein may be used in the treatment or prophylaxis of diseases associated with an alphavirus, for example, Venezuelan equine encephalitis virus (VEEV).